FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208248853> ?p ?o ?g. }

• W3208248853 endingPage "3117" @default.
• W3208248853 startingPage "3117" @default.
• W3208248853 abstract "Nuclear hormone receptors NR1D1 and NR4A2 play important roles in the synthesis and metabolism of hormones that are thought to be strictly regulated by the hypothalamus-pituitary-gonad axis (HPG) tissues via gene expression. However, in the yak, the function and regulatory mechanisms of NR1D1 and NR4A2 are not clearly understood. The current study is aimed to investigate the expression patterns, distribution and functions of these two receptors in HPG tissues in male Tianzhu white yaks. Immunohistochemical staining showed NR1D1 and NR4A2 proteins were present in all yak HPG tissues with differential expression patterns and degrees of staining, particularly in Leydig cells that were strongly positive in accordance with the immunofluorescence results. qRT-PCR and Western blot results suggested that the highest expression levels of NR1D1 and NR4A2 mRNA were present in the hypothalamus, while the expression levels of NR1D1 and NR4A2 proteins were higher in the testis and epididymis than in the hypothalamus or pituitary gland. In addition, expression levels of NR1D1 and NR4A2 mRNA and protein in testicular tissues differed by age. Expression levels were significantly higher at 6 years of age. Gene ontology (GO) and pathway analysis enrichment revealed that NR1D1 may directly regulate the synthesis and metabolism of steroid hormones via interaction with different targets, while NR4A2 may indirectly regulate the synthesis and metabolism of steroid hormones. These results showed that NR1D1 and NR4A2, as important mediators, are involved in the regulation of male yak reproduction, and especially of steroid hormones and androgen metabolism. These results will be helpful for the further understanding of the regulatory mechanisms of NR1D1 and NR4A2 in yak reproduction." @default.
• W3208248853 created "2021-11-08" @default.
• W3208248853 creator A5004233794 @default.
• W3208248853 creator A5004788999 @default.
• W3208248853 creator A5009249584 @default.
• W3208248853 creator A5017082773 @default.
• W3208248853 creator A5064222660 @default.
• W3208248853 creator A5079766143 @default.
• W3208248853 creator A5084338979 @default.
• W3208248853 creator A5086970101 @default.
• W3208248853 date "2021-10-31" @default.
• W3208248853 modified "2023-09-26" @default.
• W3208248853 title "The Distribution, Expression Patterns and Functional Analysis of NR1D1 and NR4A2 in the Reproductive Axis Tissues of the Male Tianzhu White Yak" @default.
• W3208248853 cites W1919133853 @default.
• W3208248853 cites W1981443806 @default.
• W3208248853 cites W1984144440 @default.
• W3208248853 cites W2007540087 @default.
• W3208248853 cites W2008308510 @default.
• W3208248853 cites W2019573595 @default.
• W3208248853 cites W2039048643 @default.
• W3208248853 cites W2044364067 @default.
• W3208248853 cites W2049566660 @default.
• W3208248853 cites W2060903877 @default.
• W3208248853 cites W2071028546 @default.
• W3208248853 cites W2093029383 @default.
• W3208248853 cites W2105857830 @default.
• W3208248853 cites W2108034301 @default.
• W3208248853 cites W2117963341 @default.
• W3208248853 cites W2131500559 @default.
• W3208248853 cites W2133704602 @default.
• W3208248853 cites W2134931596 @default.
• W3208248853 cites W2147322409 @default.
• W3208248853 cites W2152026276 @default.
• W3208248853 cites W2163418441 @default.
• W3208248853 cites W2327893150 @default.
• W3208248853 cites W2562061622 @default.
• W3208248853 cites W2610257194 @default.
• W3208248853 cites W2746904620 @default.
• W3208248853 cites W2782575404 @default.
• W3208248853 cites W2794180248 @default.
• W3208248853 cites W2897709111 @default.
• W3208248853 cites W2920585517 @default.
• W3208248853 cites W2942122440 @default.
• W3208248853 cites W3035726641 @default.
• W3208248853 cites W3081001294 @default.
• W3208248853 cites W3107527779 @default.
• W3208248853 cites W3137247959 @default.
• W3208248853 cites W3158701571 @default.
• W3208248853 cites W3174589131 @default.
• W3208248853 doi "https://doi.org/10.3390/ani11113117" @default.
• W3208248853 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8614427" @default.
• W3208248853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34827849" @default.
• W3208248853 hasPublicationYear "2021" @default.
• W3208248853 type Work @default.
• W3208248853 sameAs 3208248853 @default.
• W3208248853 citedByCount "6" @default.
• W3208248853 countsByYear W32082488532022 @default.
• W3208248853 countsByYear W32082488532023 @default.
• W3208248853 crossrefType "journal-article" @default.
• W3208248853 hasAuthorship W3208248853A5004233794 @default.
• W3208248853 hasAuthorship W3208248853A5004788999 @default.
• W3208248853 hasAuthorship W3208248853A5009249584 @default.
• W3208248853 hasAuthorship W3208248853A5017082773 @default.
• W3208248853 hasAuthorship W3208248853A5064222660 @default.
• W3208248853 hasAuthorship W3208248853A5079766143 @default.
• W3208248853 hasAuthorship W3208248853A5084338979 @default.
• W3208248853 hasAuthorship W3208248853A5086970101 @default.
• W3208248853 hasBestOaLocation W32082488531 @default.
• W3208248853 hasConcept C104317684 @default.
• W3208248853 hasConcept C105580179 @default.
• W3208248853 hasConcept C121608353 @default.
• W3208248853 hasConcept C126322002 @default.
• W3208248853 hasConcept C134018914 @default.
• W3208248853 hasConcept C150194340 @default.
• W3208248853 hasConcept C15660099 @default.
• W3208248853 hasConcept C165864922 @default.
• W3208248853 hasConcept C170493617 @default.
• W3208248853 hasConcept C2776415932 @default.
• W3208248853 hasConcept C530470458 @default.
• W3208248853 hasConcept C54355233 @default.
• W3208248853 hasConcept C55493867 @default.
• W3208248853 hasConcept C63932345 @default.
• W3208248853 hasConcept C71315377 @default.
• W3208248853 hasConcept C71924100 @default.
• W3208248853 hasConcept C84606932 @default.
• W3208248853 hasConcept C86339819 @default.
• W3208248853 hasConcept C86803240 @default.
• W3208248853 hasConcept C95444343 @default.
• W3208248853 hasConceptScore W3208248853C104317684 @default.
• W3208248853 hasConceptScore W3208248853C105580179 @default.
• W3208248853 hasConceptScore W3208248853C121608353 @default.
• W3208248853 hasConceptScore W3208248853C126322002 @default.
• W3208248853 hasConceptScore W3208248853C134018914 @default.
• W3208248853 hasConceptScore W3208248853C150194340 @default.
• W3208248853 hasConceptScore W3208248853C15660099 @default.
• W3208248853 hasConceptScore W3208248853C165864922 @default.
• W3208248853 hasConceptScore W3208248853C170493617 @default.
• W3208248853 hasConceptScore W3208248853C2776415932 @default.

• next