Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208249524> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W3208249524 abstract "Immune checkpoint inhibitors (ICPI) have improved progression-free survival in several solid tumors. Side effects are related to overstimulation of the immune system. Thyroid dysfunction (TD) is the most common endocrine immune-related adverse event of ICPI.To describe the clinical presentation and the course of TD in cancer patients treated with ICPI referred to an endocrinology outpatient clinic.This was a descriptive, retrospective and multicenter study of patients with TD associated with ICPI in six Spanish hospitals.120 patients (50.8% women), mean age 60 ± 12 years were included. The initial TD was hypothyroidism in 49% of patients and hyperthyroidism in 51%, with an average of 76 (41-140) and 43 (26-82) days respectively between the onset of ICPI and the analytical alteration. Significantly, the earlier the first analytical determination was, the greater the prevalence of hyperthyroidism. A turnover was observed in 80% of subjects during follow-up, mostly from hyperthyroidism to hypothyroidism. Twenty-one percent received double ICPI therapy. The most frequent form of presentation in monotherapy was hypothyroidism (57%), and in double therapy it was hyperthyroidism (77%) (p = 0.002). Patients under double therapy showed thyroid alterations earlier than those in the monotherapy group (p = 0.001). After a follow-up of 205 (112-360) days, half of the patients continued under levothyroxine treatment.Hypothyroidism and hyperthyroidism present in a similar proportion in cancer patients undergoing ICPI therapy. Our results suggest that transitory hyperthyroidism may not be detected in a relevant number of cases. In addition, TD in double therapy presents earlier. This should be taken into account in the follow-up protocols of these patients." @default.
- W3208249524 created "2021-11-08" @default.
- W3208249524 creator A5007775800 @default.
- W3208249524 creator A5028779735 @default.
- W3208249524 creator A5044505766 @default.
- W3208249524 creator A5045904085 @default.
- W3208249524 creator A5051164002 @default.
- W3208249524 creator A5051478293 @default.
- W3208249524 creator A5065561561 @default.
- W3208249524 creator A5066728358 @default.
- W3208249524 date "2021-10-01" @default.
- W3208249524 modified "2023-09-24" @default.
- W3208249524 title "Thyroid disorders associated with immune control point inhibitors" @default.
- W3208249524 cites W1562308323 @default.
- W3208249524 cites W2022073464 @default.
- W3208249524 cites W2066671159 @default.
- W3208249524 cites W2149958970 @default.
- W3208249524 cites W2278440281 @default.
- W3208249524 cites W2561156916 @default.
- W3208249524 cites W2577007969 @default.
- W3208249524 cites W2606361632 @default.
- W3208249524 cites W2607598329 @default.
- W3208249524 cites W2635292439 @default.
- W3208249524 cites W2729104836 @default.
- W3208249524 cites W2745740478 @default.
- W3208249524 cites W2755948087 @default.
- W3208249524 cites W2760410509 @default.
- W3208249524 cites W2769908638 @default.
- W3208249524 cites W2775520252 @default.
- W3208249524 cites W2782172222 @default.
- W3208249524 cites W2808713704 @default.
- W3208249524 cites W2883803370 @default.
- W3208249524 cites W2888278822 @default.
- W3208249524 cites W2891536507 @default.
- W3208249524 cites W2896138392 @default.
- W3208249524 cites W2901290947 @default.
- W3208249524 cites W2909148617 @default.
- W3208249524 cites W2912452927 @default.
- W3208249524 cites W2915955284 @default.
- W3208249524 cites W2971278617 @default.
- W3208249524 doi "https://doi.org/10.1016/j.endien.2021.10.004" @default.
- W3208249524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34742474" @default.
- W3208249524 hasPublicationYear "2021" @default.
- W3208249524 type Work @default.
- W3208249524 sameAs 3208249524 @default.
- W3208249524 citedByCount "1" @default.
- W3208249524 countsByYear W32082495242023 @default.
- W3208249524 crossrefType "journal-article" @default.
- W3208249524 hasAuthorship W3208249524A5007775800 @default.
- W3208249524 hasAuthorship W3208249524A5028779735 @default.
- W3208249524 hasAuthorship W3208249524A5044505766 @default.
- W3208249524 hasAuthorship W3208249524A5045904085 @default.
- W3208249524 hasAuthorship W3208249524A5051164002 @default.
- W3208249524 hasAuthorship W3208249524A5051478293 @default.
- W3208249524 hasAuthorship W3208249524A5065561561 @default.
- W3208249524 hasAuthorship W3208249524A5066728358 @default.
- W3208249524 hasConcept C126322002 @default.
- W3208249524 hasConcept C187212893 @default.
- W3208249524 hasConcept C197934379 @default.
- W3208249524 hasConcept C203014093 @default.
- W3208249524 hasConcept C2775883008 @default.
- W3208249524 hasConcept C2779761222 @default.
- W3208249524 hasConcept C526584372 @default.
- W3208249524 hasConcept C71924100 @default.
- W3208249524 hasConcept C8891405 @default.
- W3208249524 hasConcept C90924648 @default.
- W3208249524 hasConceptScore W3208249524C126322002 @default.
- W3208249524 hasConceptScore W3208249524C187212893 @default.
- W3208249524 hasConceptScore W3208249524C197934379 @default.
- W3208249524 hasConceptScore W3208249524C203014093 @default.
- W3208249524 hasConceptScore W3208249524C2775883008 @default.
- W3208249524 hasConceptScore W3208249524C2779761222 @default.
- W3208249524 hasConceptScore W3208249524C526584372 @default.
- W3208249524 hasConceptScore W3208249524C71924100 @default.
- W3208249524 hasConceptScore W3208249524C8891405 @default.
- W3208249524 hasConceptScore W3208249524C90924648 @default.
- W3208249524 hasLocation W32082495241 @default.
- W3208249524 hasLocation W32082495242 @default.
- W3208249524 hasOpenAccess W3208249524 @default.
- W3208249524 hasPrimaryLocation W32082495241 @default.
- W3208249524 hasRelatedWork W1904268084 @default.
- W3208249524 hasRelatedWork W2084936577 @default.
- W3208249524 hasRelatedWork W2314049084 @default.
- W3208249524 hasRelatedWork W2734194671 @default.
- W3208249524 hasRelatedWork W2748952813 @default.
- W3208249524 hasRelatedWork W2751827301 @default.
- W3208249524 hasRelatedWork W2911037216 @default.
- W3208249524 hasRelatedWork W3185803516 @default.
- W3208249524 hasRelatedWork W4229045589 @default.
- W3208249524 hasRelatedWork W4238859747 @default.
- W3208249524 isParatext "false" @default.
- W3208249524 isRetracted "false" @default.
- W3208249524 magId "3208249524" @default.
- W3208249524 workType "article" @default.