Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208253146> ?p ?o ?g. }
- W3208253146 endingPage "1746" @default.
- W3208253146 startingPage "1746" @default.
- W3208253146 abstract "Uncoupling proteins (UCPs) are transmembrane proteins members of the mitochondrial anion transporter family present in the mitochondrial inner membrane. Currently, six homologs have been identified (UCP1-6) in mammals, with ubiquitous tissue distribution and multiple physiological functions. UCPs are regulators of key events for cellular bioenergetic metabolism, such as membrane potential, metabolic efficiency, and energy dissipation also functioning as pivotal modulators of ROS production and general cellular redox state. UCPs can act as proton channels, leading to proton re-entry the mitochondrial matrix from the intermembrane space and thus collapsing the proton gradient and decreasing the membrane potential. Each homolog exhibits its specific functions, from thermogenesis to regulation of ROS production. The expression and function of UCPs are intimately linked to diabesity, with their dysregulation/dysfunction not only associated to diabesity onset, but also by exacerbating oxidative stress-related damage. Male infertility is one of the most overlooked diabesity-related comorbidities, where high oxidative stress takes a major role. In this review, we discuss in detail the expression and function of the different UCP homologs. In addition, the role of UCPs as key regulators of ROS production and redox homeostasis, as well as their influence on the pathophysiology of diabesity and potential role on diabesity-induced male infertility is debated." @default.
- W3208253146 created "2021-11-08" @default.
- W3208253146 creator A5021022567 @default.
- W3208253146 creator A5042683661 @default.
- W3208253146 creator A5053362274 @default.
- W3208253146 creator A5073431252 @default.
- W3208253146 creator A5081906480 @default.
- W3208253146 date "2021-10-30" @default.
- W3208253146 modified "2023-10-17" @default.
- W3208253146 title "Mitochondrial Uncoupling Proteins (UCPs) as Key Modulators of ROS Homeostasis: A Crosstalk between Diabesity and Male Infertility?" @default.
- W3208253146 cites W1508295900 @default.
- W3208253146 cites W1511403368 @default.
- W3208253146 cites W1556263878 @default.
- W3208253146 cites W1594539479 @default.
- W3208253146 cites W1597265569 @default.
- W3208253146 cites W1755714470 @default.
- W3208253146 cites W1849928642 @default.
- W3208253146 cites W1897668887 @default.
- W3208253146 cites W1905697185 @default.
- W3208253146 cites W1921965616 @default.
- W3208253146 cites W1957826674 @default.
- W3208253146 cites W1962155705 @default.
- W3208253146 cites W1964936390 @default.
- W3208253146 cites W1965079305 @default.
- W3208253146 cites W1966778286 @default.
- W3208253146 cites W1967961684 @default.
- W3208253146 cites W1970389856 @default.
- W3208253146 cites W1972802538 @default.
- W3208253146 cites W1973873276 @default.
- W3208253146 cites W1974867660 @default.
- W3208253146 cites W1975090760 @default.
- W3208253146 cites W1975876686 @default.
- W3208253146 cites W1975982666 @default.
- W3208253146 cites W1976748679 @default.
- W3208253146 cites W1979899140 @default.
- W3208253146 cites W1983729336 @default.
- W3208253146 cites W1984142219 @default.
- W3208253146 cites W1985245961 @default.
- W3208253146 cites W1986399270 @default.
- W3208253146 cites W1988627015 @default.
- W3208253146 cites W1990990690 @default.
- W3208253146 cites W1991444581 @default.
- W3208253146 cites W1992678387 @default.
- W3208253146 cites W2002655273 @default.
- W3208253146 cites W2002962229 @default.
- W3208253146 cites W2003961075 @default.
- W3208253146 cites W2005723843 @default.
- W3208253146 cites W2005847344 @default.
- W3208253146 cites W2006094849 @default.
- W3208253146 cites W2006107871 @default.
- W3208253146 cites W2006732634 @default.
- W3208253146 cites W2006991758 @default.
- W3208253146 cites W2008851171 @default.
- W3208253146 cites W2011738879 @default.
- W3208253146 cites W2012099220 @default.
- W3208253146 cites W2014721903 @default.
- W3208253146 cites W2016233312 @default.
- W3208253146 cites W2016603091 @default.
- W3208253146 cites W2018251802 @default.
- W3208253146 cites W2021108639 @default.
- W3208253146 cites W2022049302 @default.
- W3208253146 cites W2022443708 @default.
- W3208253146 cites W2023530279 @default.
- W3208253146 cites W2023641436 @default.
- W3208253146 cites W2024038292 @default.
- W3208253146 cites W2025664849 @default.
- W3208253146 cites W2025797599 @default.
- W3208253146 cites W2026031784 @default.
- W3208253146 cites W2027827512 @default.
- W3208253146 cites W2028132430 @default.
- W3208253146 cites W2029200993 @default.
- W3208253146 cites W2031225059 @default.
- W3208253146 cites W2032147742 @default.
- W3208253146 cites W2032814494 @default.
- W3208253146 cites W2032910880 @default.
- W3208253146 cites W2034244149 @default.
- W3208253146 cites W2034679839 @default.
- W3208253146 cites W2035707302 @default.
- W3208253146 cites W2036573181 @default.
- W3208253146 cites W2038657829 @default.
- W3208253146 cites W2039649930 @default.
- W3208253146 cites W2039992465 @default.
- W3208253146 cites W2040328785 @default.
- W3208253146 cites W2041162408 @default.
- W3208253146 cites W2044473896 @default.
- W3208253146 cites W2045387309 @default.
- W3208253146 cites W2045962129 @default.
- W3208253146 cites W2049783305 @default.
- W3208253146 cites W2051070727 @default.
- W3208253146 cites W2051505012 @default.
- W3208253146 cites W2052512498 @default.
- W3208253146 cites W2052622056 @default.
- W3208253146 cites W2052888854 @default.
- W3208253146 cites W2053286148 @default.
- W3208253146 cites W2055191740 @default.
- W3208253146 cites W2057121772 @default.
- W3208253146 cites W2057498089 @default.
- W3208253146 cites W2057683888 @default.