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- W3208261640 abstract "Neural interfaces (NIs) have traditionally used inorganic device constructs paired with electrical stimulation to bypass injured or diseased electroactive tissues. These bioinert devices have significant impact on the neural tissue, being synthetic and causing large volumetric changes to the biological environment. The concept of biomimicry has become popular for tissue engineering technologies, reflecting biological properties as a component of material design. Tissue engineering strategies can be harnessed in bioelectronic device design to improve biological tolerance, but the need for improved integration with the native tissue remains an unmet need. Adaptive biomimetic designs that respond to the changing neural tissue environment associated with wound healing can actively address the immune response to improve biointegration. These adaptive approaches include responsive materials paired with stem cells and bioactive molecules as integrated components of NIs. Combining adaptive biomimetics with NIs provides a new, more natural approach for communicating with the nervous system." @default.
- W3208261640 created "2021-11-08" @default.
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- W3208261640 date "2021-12-01" @default.
- W3208261640 modified "2023-10-18" @default.
- W3208261640 title "Adaptive biomimicry: design of neural interfaces with enhanced biointegration" @default.
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- W3208261640 doi "https://doi.org/10.1016/j.copbio.2021.10.004" @default.
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