FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208272068> ?p ?o ?g. }

• W3208272068 endingPage "260" @default.
• W3208272068 startingPage "247" @default.
• W3208272068 abstract "In addition to conventional immunoglobulin, camelids and cartilaginous fish express a special class of antibody that consists only of heavy (H) chain (HCAbs). In the holocephalan elephantfish, there are two HCAb classes, one of which has evolved surprising features. The H-chain genes in cartilaginous fish are organized as 20-200 minigenes, or clusters, each consisting of VH, 1-3 DH, JH gene segments with one set of constant region exons. We report that HHC2 (holocephalan H-chain antibody 2) evolved from IgM H-chain clusters, but its DH gene segments have diverged considerably. The three DH in HHC2 clusters are A-rich, so that one to three potential reading frames for each DH encode lysine and arginine. All three are incorporated into the rearranged VDJ, ensuring that the ligand-binding site carries multiple basic residues, as cDNA sequences demonstrate. The electropositive character in HHC2 CDR3 is accompanied by a paucity of aromatic amino acids, the latter feature at variance to the established, interactive role of tyrosine not only in ligand-binding but generally at interfaces of protein complexes. The selection for these divergent HHC2 features challenges currently accepted ideas on what determines antibody reactivity and molecular recognition." @default.
• W3208272068 created "2021-11-08" @default.
• W3208272068 creator A5012190094 @default.
• W3208272068 creator A5013664990 @default.
• W3208272068 creator A5035900372 @default.
• W3208272068 creator A5036209141 @default.
• W3208272068 creator A5054991162 @default.
• W3208272068 date "2021-11-19" @default.
• W3208272068 modified "2023-10-02" @default.
• W3208272068 title "Heavy chain‐only antibody genes in fish evolved to generate unique CDR3 repertoire" @default.
• W3208272068 cites W1024729339 @default.
• W3208272068 cites W1221610919 @default.
• W3208272068 cites W1526921084 @default.
• W3208272068 cites W1591211464 @default.
• W3208272068 cites W1603383430 @default.
• W3208272068 cites W1608855442 @default.
• W3208272068 cites W1677824387 @default.
• W3208272068 cites W1825594926 @default.
• W3208272068 cites W1934751711 @default.
• W3208272068 cites W1939794195 @default.
• W3208272068 cites W1964538987 @default.
• W3208272068 cites W1967403612 @default.
• W3208272068 cites W1967867591 @default.
• W3208272068 cites W1968554285 @default.
• W3208272068 cites W1978090240 @default.
• W3208272068 cites W1983263967 @default.
• W3208272068 cites W1984387553 @default.
• W3208272068 cites W1990205754 @default.
• W3208272068 cites W1992975997 @default.
• W3208272068 cites W1998255234 @default.
• W3208272068 cites W2005855621 @default.
• W3208272068 cites W2005997381 @default.
• W3208272068 cites W2007054796 @default.
• W3208272068 cites W2007647936 @default.
• W3208272068 cites W2012621186 @default.
• W3208272068 cites W2015848842 @default.
• W3208272068 cites W2023485491 @default.
• W3208272068 cites W2024707982 @default.
• W3208272068 cites W2031989831 @default.
• W3208272068 cites W2037042031 @default.
• W3208272068 cites W2041654300 @default.
• W3208272068 cites W2052093850 @default.
• W3208272068 cites W2053469790 @default.
• W3208272068 cites W2061041720 @default.
• W3208272068 cites W2061352595 @default.
• W3208272068 cites W2061410538 @default.
• W3208272068 cites W2063712078 @default.
• W3208272068 cites W2064106659 @default.
• W3208272068 cites W2070814047 @default.
• W3208272068 cites W2072854137 @default.
• W3208272068 cites W2076198413 @default.
• W3208272068 cites W2083434612 @default.
• W3208272068 cites W2091477384 @default.
• W3208272068 cites W2100213817 @default.
• W3208272068 cites W2105360462 @default.
• W3208272068 cites W2115982185 @default.
• W3208272068 cites W2128360360 @default.
• W3208272068 cites W2132514101 @default.
• W3208272068 cites W2140060739 @default.
• W3208272068 cites W2144847094 @default.
• W3208272068 cites W2150804466 @default.
• W3208272068 cites W2155859779 @default.
• W3208272068 cites W2158347168 @default.
• W3208272068 cites W2158992634 @default.
• W3208272068 cites W2161831419 @default.
• W3208272068 cites W2166975108 @default.
• W3208272068 cites W2167863101 @default.
• W3208272068 cites W2169610187 @default.
• W3208272068 cites W2337167212 @default.
• W3208272068 cites W2343191045 @default.
• W3208272068 cites W2409875835 @default.
• W3208272068 cites W2498297736 @default.
• W3208272068 cites W2745083409 @default.
• W3208272068 cites W2772676916 @default.
• W3208272068 cites W2785884569 @default.
• W3208272068 cites W2790912632 @default.
• W3208272068 cites W2795909740 @default.
• W3208272068 cites W2809145153 @default.
• W3208272068 cites W2810444941 @default.
• W3208272068 cites W2932554868 @default.
• W3208272068 cites W2945004385 @default.
• W3208272068 doi "https://doi.org/10.1002/eji.202149588" @default.
• W3208272068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34708869" @default.
• W3208272068 hasPublicationYear "2021" @default.
• W3208272068 type Work @default.
• W3208272068 sameAs 3208272068 @default.
• W3208272068 citedByCount "1" @default.
• W3208272068 countsByYear W32082720682023 @default.
• W3208272068 crossrefType "journal-article" @default.
• W3208272068 hasAuthorship W3208272068A5012190094 @default.
• W3208272068 hasAuthorship W3208272068A5013664990 @default.
• W3208272068 hasAuthorship W3208272068A5035900372 @default.
• W3208272068 hasAuthorship W3208272068A5036209141 @default.
• W3208272068 hasAuthorship W3208272068A5054991162 @default.
• W3208272068 hasBestOaLocation W32082720681 @default.
• W3208272068 hasConcept C104317684 @default.
• W3208272068 hasConcept C159654299 @default.
• W3208272068 hasConcept C187882448 @default.

• next