FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208274090> ?p ?o ?g. }

• W3208274090 endingPage "266" @default.
• W3208274090 startingPage "256" @default.
• W3208274090 abstract "Background Pregnant women have been identified as a potentially at‐risk group concerning COVID‐19 infection, but little is known regarding the susceptibility of the fetus to infection. Co‐expression of ACE2 and TMPRSS2 has been identified as a prerequisite for infection, and expression across different tissues is known to vary between children and adults. However, the expression of these proteins in the fetus is unknown. Methods We performed a retrospective analysis of a single cell data repository. The data were then validated at both gene and protein level by performing RT‐qPCR and two‐colour immunohistochemistry on a library of second‐trimester human fetal tissues. Findings TMPRSS2 is present at both gene and protein level in the predominantly epithelial fetal tissues analysed. ACE2 is present at significant levels only in the fetal intestine and kidney, and is not expressed in the fetal lung. The placenta also does not co‐express the two proteins across the second trimester or at term. Interpretation This dataset indicates that the lungs are unlikely to be a viable route of SARS‐CoV2 fetal infection. The fetal kidney, despite presenting both the proteins required for the infection, is anatomically protected from the exposure to the virus. However, the gastrointestinal tract is likely to be susceptible to infection due to its high co‐expression of both proteins, as well as its exposure to potentially infected amniotic fluid. Tweetable abstract This work provides detailed mechanistic insight into the relative protection & vulnerabilities of the fetus & placenta to SARS‐CoV‐2 infection by scRNAseq & protein expression analysis for ACE2 & TMPRSS2. The findings help to explain the low rate of vertical transmission." @default.
• W3208274090 created "2021-11-08" @default.
• W3208274090 creator A5017673527 @default.
• W3208274090 creator A5023232987 @default.
• W3208274090 creator A5036632967 @default.
• W3208274090 creator A5037501835 @default.
• W3208274090 creator A5041596317 @default.
• W3208274090 creator A5045095424 @default.
• W3208274090 creator A5046798141 @default.
• W3208274090 creator A5053732994 @default.
• W3208274090 creator A5055496507 @default.
• W3208274090 creator A5072085597 @default.
• W3208274090 creator A5072846093 @default.
• W3208274090 creator A5085664156 @default.
• W3208274090 creator A5089509461 @default.
• W3208274090 date "2021-11-18" @default.
• W3208274090 modified "2023-10-11" @default.
• W3208274090 title "COVID‐19 and vertical transmission: assessing the expression of ACE2/TMPRSS2 in the human fetus and placenta to assess the risk of SARS‐CoV‐2 infection" @default.
• W3208274090 cites W2007397909 @default.
• W3208274090 cites W2012034410 @default.
• W3208274090 cites W2107277218 @default.
• W3208274090 cites W2192080449 @default.
• W3208274090 cites W2580657348 @default.
• W3208274090 cites W2806669511 @default.
• W3208274090 cites W2952481429 @default.
• W3208274090 cites W2999438316 @default.
• W3208274090 cites W3005679569 @default.
• W3208274090 cites W3012611938 @default.
• W3208274090 cites W3013885273 @default.
• W3208274090 cites W3017101807 @default.
• W3208274090 cites W3020909574 @default.
• W3208274090 cites W3033407036 @default.
• W3208274090 cites W3033466557 @default.
• W3208274090 cites W3038049367 @default.
• W3208274090 cites W3038125086 @default.
• W3208274090 cites W3038780389 @default.
• W3208274090 cites W3043371969 @default.
• W3208274090 cites W3044585503 @default.
• W3208274090 cites W3046373756 @default.
• W3208274090 cites W3047570184 @default.
• W3208274090 cites W3049697999 @default.
• W3208274090 cites W3073949878 @default.
• W3208274090 cites W3080259982 @default.
• W3208274090 cites W3080516395 @default.
• W3208274090 cites W3082662646 @default.
• W3208274090 cites W3092146863 @default.
• W3208274090 cites W3093867667 @default.
• W3208274090 cites W3094419073 @default.
• W3208274090 cites W3096610553 @default.
• W3208274090 cites W3103797259 @default.
• W3208274090 cites W3118589983 @default.
• W3208274090 cites W3131717088 @default.
• W3208274090 cites W3155022585 @default.
• W3208274090 cites W3157791544 @default.
• W3208274090 cites W3172057702 @default.
• W3208274090 cites W3172825783 @default.
• W3208274090 cites W3177498425 @default.
• W3208274090 cites W3177835915 @default.
• W3208274090 cites W3181055919 @default.
• W3208274090 cites W3183417174 @default.
• W3208274090 cites W3188083250 @default.
• W3208274090 cites W3194597260 @default.
• W3208274090 cites W3201255453 @default.
• W3208274090 cites W3201855939 @default.
• W3208274090 cites W3208274090 @default.
• W3208274090 cites W3213763559 @default.
• W3208274090 doi "https://doi.org/10.1111/1471-0528.16974" @default.
• W3208274090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34735736" @default.
• W3208274090 hasPublicationYear "2021" @default.
• W3208274090 type Work @default.
• W3208274090 sameAs 3208274090 @default.
• W3208274090 citedByCount "21" @default.
• W3208274090 countsByYear W32082740902021 @default.
• W3208274090 countsByYear W32082740902022 @default.
• W3208274090 countsByYear W32082740902023 @default.
• W3208274090 crossrefType "journal-article" @default.
• W3208274090 hasAuthorship W3208274090A5017673527 @default.
• W3208274090 hasAuthorship W3208274090A5023232987 @default.
• W3208274090 hasAuthorship W3208274090A5036632967 @default.
• W3208274090 hasAuthorship W3208274090A5037501835 @default.
• W3208274090 hasAuthorship W3208274090A5041596317 @default.
• W3208274090 hasAuthorship W3208274090A5045095424 @default.
• W3208274090 hasAuthorship W3208274090A5046798141 @default.
• W3208274090 hasAuthorship W3208274090A5053732994 @default.
• W3208274090 hasAuthorship W3208274090A5055496507 @default.
• W3208274090 hasAuthorship W3208274090A5072085597 @default.
• W3208274090 hasAuthorship W3208274090A5072846093 @default.
• W3208274090 hasAuthorship W3208274090A5085664156 @default.
• W3208274090 hasAuthorship W3208274090A5089509461 @default.
• W3208274090 hasBestOaLocation W32082740901 @default.
• W3208274090 hasConcept C104317684 @default.
• W3208274090 hasConcept C150194340 @default.
• W3208274090 hasConcept C16685009 @default.
• W3208274090 hasConcept C172680121 @default.
• W3208274090 hasConcept C203014093 @default.
• W3208274090 hasConcept C204232928 @default.
• W3208274090 hasConcept C2776953305 @default.
• W3208274090 hasConcept C2778194526 @default.

• next