Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208274298> ?p ?o ?g. }
- W3208274298 abstract "The cellular prion protein (PrPC) is a mainly α-helical 208-residue protein located in the pre- and postsynaptic membranes. For unknown reasons, PrPC can undergo a structural transition into a toxic, β-sheet rich scrapie isoform (PrPSc) that is responsible for transmissible spongiform encephalopathies (TSEs). Metal ions seem to play an important role in the structural conversion. PrPC binds Zn(II) ions and may be involved in metal ion transport and zinc homeostasis. Here, we use multiple biophysical techniques including optical and NMR spectroscopy, molecular dynamics simulations, and small angle X-ray scattering to characterize interactions between human PrPC and Zn(II) ions. Binding of a single Zn(II) ion to the PrPC N-terminal domain via four His residues from the octarepeat region induces a structural transition in the C-terminal α-helices 2 and 3, promotes interaction between the N-terminal and C-terminal domains, reduces the folded protein size, and modifies the internal structural dynamics. As our results suggest that PrPC can bind Zn(II) under physiological conditions, these effects could be important for the physiological function of PrPC." @default.
- W3208274298 created "2021-11-08" @default.
- W3208274298 creator A5010189165 @default.
- W3208274298 creator A5011442585 @default.
- W3208274298 creator A5033170495 @default.
- W3208274298 creator A5034635485 @default.
- W3208274298 creator A5041919771 @default.
- W3208274298 creator A5048514475 @default.
- W3208274298 creator A5052002363 @default.
- W3208274298 creator A5075668441 @default.
- W3208274298 creator A5080087140 @default.
- W3208274298 date "2021-11-04" @default.
- W3208274298 modified "2023-09-26" @default.
- W3208274298 title "Zn(II) binding causes interdomain changes in the structure and flexibility of the human prion protein" @default.
- W3208274298 cites W1031578623 @default.
- W3208274298 cites W1480121071 @default.
- W3208274298 cites W1491824558 @default.
- W3208274298 cites W1511938293 @default.
- W3208274298 cites W1536886974 @default.
- W3208274298 cites W1588979652 @default.
- W3208274298 cites W1964352617 @default.
- W3208274298 cites W1965265620 @default.
- W3208274298 cites W1965667994 @default.
- W3208274298 cites W1968830969 @default.
- W3208274298 cites W1970001562 @default.
- W3208274298 cites W1977038370 @default.
- W3208274298 cites W1978746207 @default.
- W3208274298 cites W1981250435 @default.
- W3208274298 cites W1981346588 @default.
- W3208274298 cites W1982126789 @default.
- W3208274298 cites W1984447887 @default.
- W3208274298 cites W1987566729 @default.
- W3208274298 cites W1991647860 @default.
- W3208274298 cites W1996941571 @default.
- W3208274298 cites W1996947727 @default.
- W3208274298 cites W2003129868 @default.
- W3208274298 cites W2008636063 @default.
- W3208274298 cites W2012128918 @default.
- W3208274298 cites W2014235932 @default.
- W3208274298 cites W2017014906 @default.
- W3208274298 cites W2021116136 @default.
- W3208274298 cites W2023338142 @default.
- W3208274298 cites W2027793140 @default.
- W3208274298 cites W2029667189 @default.
- W3208274298 cites W2030091053 @default.
- W3208274298 cites W2030841140 @default.
- W3208274298 cites W2035687084 @default.
- W3208274298 cites W2043177258 @default.
- W3208274298 cites W2044687881 @default.
- W3208274298 cites W2045751102 @default.
- W3208274298 cites W2048967679 @default.
- W3208274298 cites W2053023567 @default.
- W3208274298 cites W2053636966 @default.
- W3208274298 cites W2057477511 @default.
- W3208274298 cites W2059532613 @default.
- W3208274298 cites W2063984339 @default.
- W3208274298 cites W2068548707 @default.
- W3208274298 cites W2069602336 @default.
- W3208274298 cites W2070989278 @default.
- W3208274298 cites W2076146345 @default.
- W3208274298 cites W2078131661 @default.
- W3208274298 cites W2081693079 @default.
- W3208274298 cites W2084761689 @default.
- W3208274298 cites W2088793021 @default.
- W3208274298 cites W2095402560 @default.
- W3208274298 cites W2096423704 @default.
- W3208274298 cites W2101137910 @default.
- W3208274298 cites W2103613160 @default.
- W3208274298 cites W2103945336 @default.
- W3208274298 cites W2106306100 @default.
- W3208274298 cites W2109401365 @default.
- W3208274298 cites W2123709136 @default.
- W3208274298 cites W2127522551 @default.
- W3208274298 cites W2128572087 @default.
- W3208274298 cites W2129879061 @default.
- W3208274298 cites W2136332525 @default.
- W3208274298 cites W2136857248 @default.
- W3208274298 cites W2147276565 @default.
- W3208274298 cites W2150576297 @default.
- W3208274298 cites W2151295232 @default.
- W3208274298 cites W2154473726 @default.
- W3208274298 cites W2157784883 @default.
- W3208274298 cites W2169821755 @default.
- W3208274298 cites W2170146374 @default.
- W3208274298 cites W2324660492 @default.
- W3208274298 cites W2342806262 @default.
- W3208274298 cites W2409802975 @default.
- W3208274298 cites W2588040733 @default.
- W3208274298 cites W2604252203 @default.
- W3208274298 cites W2611707378 @default.
- W3208274298 cites W2707646777 @default.
- W3208274298 cites W2739492216 @default.
- W3208274298 cites W2889109666 @default.
- W3208274298 cites W2908786056 @default.
- W3208274298 cites W2930821061 @default.
- W3208274298 cites W2957083874 @default.
- W3208274298 cites W2975314712 @default.
- W3208274298 cites W3120169644 @default.
- W3208274298 cites W3126060668 @default.
- W3208274298 cites W4211121722 @default.