Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208276566> ?p ?o ?g. }
- W3208276566 abstract "Objective: Anxiety and depression are prominent non-motor symptoms of Parkinson's disease (PD), but their pathophysiology remains unclear. We sought to understand their neurophysiological correlates from chronic invasive recordings of the prefrontal cortex (PFC). Methods: We studied four patients undergoing deep brain stimulation (DBS) for their motor signs, who had comorbid mild to moderate anxiety and/or depressive symptoms. In addition to their basal ganglia leads, we placed a permanent prefrontal subdural 4-contact lead. These electrodes were attached to an investigational pulse generator with the capability to sense and store field potential signals, as well as deliver therapeutic neurostimulation. At regular intervals over 3-5 months, participants paired brief invasive neural recordings with self-ratings of symptoms related to depression and anxiety. Results: Mean age was 61 ± 7 years, mean disease duration was 11 ± 8 years and a mean Unified Parkinson's Disease Rating Scale, with part III (UPDRS-III) off medication score of 37 ± 13. Mean Beck Depression Inventory (BDI) score was 14 ± 5 and Beck Anxiety Index was 16.5 ± 5. Prefrontal cortex spectral power in the beta band correlated with patient self-ratings of symptoms of depression and anxiety, with r-values between 0.31 and 0.48. Mood scores showed negative correlation with beta spectral power in lateral locations, and positive correlation with beta spectral power in a mesial recording location, consistent with the dichotomous organization of reward networks in PFC. Interpretation: These findings suggest a physiological basis for anxiety and depression in PD, which may be useful in the development of neurostimulation paradigms for these non-motor disease features." @default.
- W3208276566 created "2021-11-08" @default.
- W3208276566 creator A5004124787 @default.
- W3208276566 creator A5011491202 @default.
- W3208276566 creator A5012162648 @default.
- W3208276566 creator A5019667316 @default.
- W3208276566 creator A5024860464 @default.
- W3208276566 creator A5027915708 @default.
- W3208276566 creator A5034688564 @default.
- W3208276566 creator A5034791416 @default.
- W3208276566 creator A5042961296 @default.
- W3208276566 creator A5043848294 @default.
- W3208276566 creator A5058848174 @default.
- W3208276566 creator A5062021345 @default.
- W3208276566 creator A5068672154 @default.
- W3208276566 creator A5075173157 @default.
- W3208276566 creator A5083224408 @default.
- W3208276566 creator A5091099837 @default.
- W3208276566 date "2021-10-21" @default.
- W3208276566 modified "2023-10-01" @default.
- W3208276566 title "Prefrontal Physiomarkers of Anxiety and Depression in Parkinson’s Disease" @default.
- W3208276566 cites W1977264478 @default.
- W3208276566 cites W1983965289 @default.
- W3208276566 cites W1995130940 @default.
- W3208276566 cites W2004293194 @default.
- W3208276566 cites W2015743230 @default.
- W3208276566 cites W2023266218 @default.
- W3208276566 cites W2059372579 @default.
- W3208276566 cites W2101135654 @default.
- W3208276566 cites W2102142042 @default.
- W3208276566 cites W2112455323 @default.
- W3208276566 cites W2133947591 @default.
- W3208276566 cites W2147925216 @default.
- W3208276566 cites W2151721316 @default.
- W3208276566 cites W2168138675 @default.
- W3208276566 cites W2261110543 @default.
- W3208276566 cites W2277882088 @default.
- W3208276566 cites W2300653562 @default.
- W3208276566 cites W2371895244 @default.
- W3208276566 cites W2423154567 @default.
- W3208276566 cites W2515350692 @default.
- W3208276566 cites W2526989977 @default.
- W3208276566 cites W2552766899 @default.
- W3208276566 cites W2556362768 @default.
- W3208276566 cites W2577767589 @default.
- W3208276566 cites W2590346783 @default.
- W3208276566 cites W2591639181 @default.
- W3208276566 cites W2605702050 @default.
- W3208276566 cites W2607088157 @default.
- W3208276566 cites W2616962738 @default.
- W3208276566 cites W2620688797 @default.
- W3208276566 cites W2622883011 @default.
- W3208276566 cites W2752738660 @default.
- W3208276566 cites W2754609812 @default.
- W3208276566 cites W2765117211 @default.
- W3208276566 cites W2792756574 @default.
- W3208276566 cites W2890134246 @default.
- W3208276566 cites W2891509242 @default.
- W3208276566 cites W2899579807 @default.
- W3208276566 cites W2900127046 @default.
- W3208276566 cites W2903033387 @default.
- W3208276566 cites W2908548900 @default.
- W3208276566 cites W2958634274 @default.
- W3208276566 cites W2963206879 @default.
- W3208276566 cites W2969193921 @default.
- W3208276566 cites W2977374457 @default.
- W3208276566 cites W2996282442 @default.
- W3208276566 cites W3003982506 @default.
- W3208276566 cites W3004336803 @default.
- W3208276566 cites W3008049631 @default.
- W3208276566 cites W3158340479 @default.
- W3208276566 doi "https://doi.org/10.3389/fnins.2021.748165" @default.
- W3208276566 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8568318" @default.
- W3208276566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34744613" @default.
- W3208276566 hasPublicationYear "2021" @default.
- W3208276566 type Work @default.
- W3208276566 sameAs 3208276566 @default.
- W3208276566 citedByCount "10" @default.
- W3208276566 countsByYear W32082765662021 @default.
- W3208276566 countsByYear W32082765662022 @default.
- W3208276566 countsByYear W32082765662023 @default.
- W3208276566 crossrefType "journal-article" @default.
- W3208276566 hasAuthorship W3208276566A5004124787 @default.
- W3208276566 hasAuthorship W3208276566A5011491202 @default.
- W3208276566 hasAuthorship W3208276566A5012162648 @default.
- W3208276566 hasAuthorship W3208276566A5019667316 @default.
- W3208276566 hasAuthorship W3208276566A5024860464 @default.
- W3208276566 hasAuthorship W3208276566A5027915708 @default.
- W3208276566 hasAuthorship W3208276566A5034688564 @default.
- W3208276566 hasAuthorship W3208276566A5034791416 @default.
- W3208276566 hasAuthorship W3208276566A5042961296 @default.
- W3208276566 hasAuthorship W3208276566A5043848294 @default.
- W3208276566 hasAuthorship W3208276566A5058848174 @default.
- W3208276566 hasAuthorship W3208276566A5062021345 @default.
- W3208276566 hasAuthorship W3208276566A5068672154 @default.
- W3208276566 hasAuthorship W3208276566A5075173157 @default.
- W3208276566 hasAuthorship W3208276566A5083224408 @default.
- W3208276566 hasAuthorship W3208276566A5091099837 @default.
- W3208276566 hasBestOaLocation W32082765661 @default.
- W3208276566 hasConcept C118552586 @default.