Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208278630> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W3208278630 abstract "The tumor suppressor protein BRCA1 plays an important role in DNA repair by homologous recombination. Despite being encoded by the first familial breast and ovarian cancer gene identified, how BRCA1 is recruited to sites of DNA damage to execute its repair functions has remained poorly understood. Several recent studies highlight the role of its constitutive interaction partner BARD1 in this process. In this issue, parallel work by Sherker et al (2021) focused on a second route of BRCA1 recruitment, connected to the BRCA1-A complex protein RAP80. Studying BRCA1 recruitment in RAP80-deficient cells exposed a critical role for the BRCA1 RING domain and its associated ubiquitin ligase activity. Given that tumors expressing RING-less BRCA1 isoforms can become resistant to therapy, targeting the RAP80 recruitment axis in such tumors might restore effective treatment." @default.
- W3208278630 created "2021-11-08" @default.
- W3208278630 creator A5019049900 @default.
- W3208278630 creator A5080655208 @default.
- W3208278630 date "2021-11-02" @default.
- W3208278630 modified "2023-10-12" @default.
- W3208278630 title "When the RAP (80) fades out, you can hear BRCA1 RING" @default.
- W3208278630 cites W2382242955 @default.
- W3208278630 cites W2915095776 @default.
- W3208278630 cites W3007516256 @default.
- W3208278630 cites W3133450021 @default.
- W3208278630 cites W3146393051 @default.
- W3208278630 cites W3167873624 @default.
- W3208278630 cites W3184657756 @default.
- W3208278630 cites W3186939347 @default.
- W3208278630 cites W3194892592 @default.
- W3208278630 cites W3208278630 @default.
- W3208278630 cites W3211209509 @default.
- W3208278630 doi "https://doi.org/10.15252/embr.202154116" @default.
- W3208278630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34726332" @default.
- W3208278630 hasPublicationYear "2021" @default.
- W3208278630 type Work @default.
- W3208278630 sameAs 3208278630 @default.
- W3208278630 citedByCount "1" @default.
- W3208278630 countsByYear W32082786302021 @default.
- W3208278630 crossrefType "journal-article" @default.
- W3208278630 hasAuthorship W3208278630A5019049900 @default.
- W3208278630 hasAuthorship W3208278630A5080655208 @default.
- W3208278630 hasBestOaLocation W32082786301 @default.
- W3208278630 hasConcept C102744134 @default.
- W3208278630 hasConcept C104317684 @default.
- W3208278630 hasConcept C134459356 @default.
- W3208278630 hasConcept C134935766 @default.
- W3208278630 hasConcept C143425029 @default.
- W3208278630 hasConcept C25602115 @default.
- W3208278630 hasConcept C502942594 @default.
- W3208278630 hasConcept C54355233 @default.
- W3208278630 hasConcept C552990157 @default.
- W3208278630 hasConcept C86803240 @default.
- W3208278630 hasConcept C95444343 @default.
- W3208278630 hasConceptScore W3208278630C102744134 @default.
- W3208278630 hasConceptScore W3208278630C104317684 @default.
- W3208278630 hasConceptScore W3208278630C134459356 @default.
- W3208278630 hasConceptScore W3208278630C134935766 @default.
- W3208278630 hasConceptScore W3208278630C143425029 @default.
- W3208278630 hasConceptScore W3208278630C25602115 @default.
- W3208278630 hasConceptScore W3208278630C502942594 @default.
- W3208278630 hasConceptScore W3208278630C54355233 @default.
- W3208278630 hasConceptScore W3208278630C552990157 @default.
- W3208278630 hasConceptScore W3208278630C86803240 @default.
- W3208278630 hasConceptScore W3208278630C95444343 @default.
- W3208278630 hasIssue "12" @default.
- W3208278630 hasLocation W32082786301 @default.
- W3208278630 hasLocation W32082786302 @default.
- W3208278630 hasLocation W32082786303 @default.
- W3208278630 hasLocation W32082786304 @default.
- W3208278630 hasOpenAccess W3208278630 @default.
- W3208278630 hasPrimaryLocation W32082786301 @default.
- W3208278630 hasRelatedWork W1991256573 @default.
- W3208278630 hasRelatedWork W2021044341 @default.
- W3208278630 hasRelatedWork W2058471321 @default.
- W3208278630 hasRelatedWork W2095594147 @default.
- W3208278630 hasRelatedWork W2128114411 @default.
- W3208278630 hasRelatedWork W2140740835 @default.
- W3208278630 hasRelatedWork W2911246008 @default.
- W3208278630 hasRelatedWork W2941810629 @default.
- W3208278630 hasRelatedWork W3175159051 @default.
- W3208278630 hasRelatedWork W3194892592 @default.
- W3208278630 hasVolume "22" @default.
- W3208278630 isParatext "false" @default.
- W3208278630 isRetracted "false" @default.
- W3208278630 magId "3208278630" @default.
- W3208278630 workType "article" @default.