FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208279442> ?p ?o ?g. }

• W3208279442 endingPage "11881" @default.
• W3208279442 startingPage "11881" @default.
• W3208279442 abstract "We sought to identify therapeutic targets for breast cancer by investigating the metabolic symbiosis between breast cancer and adipose tissue. To this end, we compared orthotopic E0771 breast cancer tumors that were in direct contact with adipose tissue with ectopic E0771 tumors in mice. Orthotopic tumors grew faster and displayed increased de novo lipogenesis compared to ectopic tumors. Adipocytes release large amounts of lactate, and we found that both lactate pretreatment and adipose tissue co-culture augmented de novo lipogenesis in E0771 cells. Continuous treatment with the selective FASN inhibitor Fasnall dose-dependently decreased the E0771 viability in vitro. However, daily Fasnall injections were effective only in 50% of the tumors, while the other 50% displayed accelerated growth. These opposing effects of Fasnall in vivo was recapitulated in vitro; intermittent Fasnall treatment increased the E0771 viability at lower concentrations and suppressed the viability at higher concentrations. In conclusion, our data suggest that adipose tissue enhances tumor growth by stimulating lipogenesis. However, targeting lipogenesis alone can be deleterious. To circumvent the tumor's ability to adapt to treatment, we therefore believe that it is necessary to apply an aggressive treatment, preferably targeting several metabolic pathways simultaneously, together with conventional therapy." @default.
• W3208279442 created "2021-11-08" @default.
• W3208279442 creator A5004874978 @default.
• W3208279442 creator A5011475829 @default.
• W3208279442 creator A5019641191 @default.
• W3208279442 creator A5032972608 @default.
• W3208279442 creator A5048324714 @default.
• W3208279442 creator A5064944204 @default.
• W3208279442 creator A5068222935 @default.
• W3208279442 creator A5089869894 @default.
• W3208279442 date "2021-11-02" @default.
• W3208279442 modified "2023-09-26" @default.
• W3208279442 title "Adipose Tissue—Breast Cancer Crosstalk Leads to Increased Tumor Lipogenesis Associated with Enhanced Tumor Growth" @default.
• W3208279442 cites W1493525611 @default.
• W3208279442 cites W1980568044 @default.
• W3208279442 cites W1989294105 @default.
• W3208279442 cites W1994796378 @default.
• W3208279442 cites W1995092745 @default.
• W3208279442 cites W2004750645 @default.
• W3208279442 cites W2014349355 @default.
• W3208279442 cites W2016921045 @default.
• W3208279442 cites W2017093906 @default.
• W3208279442 cites W2017703699 @default.
• W3208279442 cites W2019399063 @default.
• W3208279442 cites W2040532875 @default.
• W3208279442 cites W2041237929 @default.
• W3208279442 cites W2049497945 @default.
• W3208279442 cites W2050509217 @default.
• W3208279442 cites W2057441939 @default.
• W3208279442 cites W2059099021 @default.
• W3208279442 cites W2079613095 @default.
• W3208279442 cites W2086825927 @default.
• W3208279442 cites W2094115400 @default.
• W3208279442 cites W2098575798 @default.
• W3208279442 cites W2115226530 @default.
• W3208279442 cites W2127675410 @default.
• W3208279442 cites W2130242207 @default.
• W3208279442 cites W2147013786 @default.
• W3208279442 cites W2153178365 @default.
• W3208279442 cites W2169024285 @default.
• W3208279442 cites W2312266417 @default.
• W3208279442 cites W2409217406 @default.
• W3208279442 cites W2414985384 @default.
• W3208279442 cites W2523687917 @default.
• W3208279442 cites W2567661897 @default.
• W3208279442 cites W2573612572 @default.
• W3208279442 cites W2589120174 @default.
• W3208279442 cites W2589411605 @default.
• W3208279442 cites W2604403946 @default.
• W3208279442 cites W2759978833 @default.
• W3208279442 cites W2761809127 @default.
• W3208279442 cites W2796192631 @default.
• W3208279442 cites W2861440206 @default.
• W3208279442 cites W2926781175 @default.
• W3208279442 cites W2946514883 @default.
• W3208279442 cites W2985753680 @default.
• W3208279442 cites W2999288416 @default.
• W3208279442 cites W3018397450 @default.
• W3208279442 cites W3043753157 @default.
• W3208279442 cites W3049069589 @default.
• W3208279442 cites W3092926590 @default.
• W3208279442 cites W3111111721 @default.
• W3208279442 cites W3125057664 @default.
• W3208279442 cites W3134118467 @default.
• W3208279442 cites W4323238517 @default.
• W3208279442 doi "https://doi.org/10.3390/ijms222111881" @default.
• W3208279442 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8585035" @default.
• W3208279442 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34769312" @default.
• W3208279442 hasPublicationYear "2021" @default.
• W3208279442 type Work @default.
• W3208279442 sameAs 3208279442 @default.
• W3208279442 citedByCount "6" @default.
• W3208279442 countsByYear W32082794422022 @default.
• W3208279442 countsByYear W32082794422023 @default.
• W3208279442 crossrefType "journal-article" @default.
• W3208279442 hasAuthorship W3208279442A5004874978 @default.
• W3208279442 hasAuthorship W3208279442A5011475829 @default.
• W3208279442 hasAuthorship W3208279442A5019641191 @default.
• W3208279442 hasAuthorship W3208279442A5032972608 @default.
• W3208279442 hasAuthorship W3208279442A5048324714 @default.
• W3208279442 hasAuthorship W3208279442A5064944204 @default.
• W3208279442 hasAuthorship W3208279442A5068222935 @default.
• W3208279442 hasAuthorship W3208279442A5089869894 @default.
• W3208279442 hasBestOaLocation W32082794421 @default.
• W3208279442 hasConcept C121608353 @default.
• W3208279442 hasConcept C126322002 @default.
• W3208279442 hasConcept C134018914 @default.
• W3208279442 hasConcept C141359234 @default.
• W3208279442 hasConcept C150903083 @default.
• W3208279442 hasConcept C171089720 @default.
• W3208279442 hasConcept C185592680 @default.
• W3208279442 hasConcept C207001950 @default.
• W3208279442 hasConcept C502942594 @default.
• W3208279442 hasConcept C530470458 @default.
• W3208279442 hasConcept C71924100 @default.
• W3208279442 hasConcept C86803240 @default.
• W3208279442 hasConceptScore W3208279442C121608353 @default.
• W3208279442 hasConceptScore W3208279442C126322002 @default.

• next