Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208287615> ?p ?o ?g. }
- W3208287615 endingPage "6243" @default.
- W3208287615 startingPage "6231" @default.
- W3208287615 abstract "Previous studies on the mechanism of proliferation and cell cycle progression of gastric cancer cells have shown promising perspectives for the prevention and treatment of gastric cancer. The aim of the present study was to investigate the role of lemur tyrosine kinase 2 (LMTK2) in gastric cancer cell proliferation and cell cycle progression, as well as in tumor-bearing nude mouse models. The expression levels of LMTK2 were determined in gastric cancer cell lines. In addition, the effects of LMTK2 silencing or overexpression on cell proliferation were measured using Cell Counting Kit-8, BrdU and colony formation assays. Cell cycle progression was analyzed using flow cytometry and western blotting. The expression levels of proteins associated with the β-catenin pathway were assessed using western blot analysis. A tumor-bearing nude mouse model was established by injecting gastric cancer cells, and the effect of LMTK2 knockdown or overexpression on tumor growth was examined. The expression levels of LMTK2 were found to be upregulated in all gastric cancer cell lines. Moreover, LMTK2 knockdown inhibited cell proliferation, colony formation and cell cycle progression. LMTK2 knockdown also inhibited the activation of GSK-3β/β-catenin signaling, as evidenced by reduced GSK-3β phosphorylation and nuclear β-catenin levels. LMTK2 knockdown also suppressed tumor growth, whereas overexpression accelerated this process. In conclusion, LMTK2 silencing can inhibit the proliferation of gastric cancer cells in vitro and tumor growth in vivo by regulating GSK-3β phosphorylation and β-catenin nuclear translocation." @default.
- W3208287615 created "2021-11-08" @default.
- W3208287615 creator A5010139327 @default.
- W3208287615 creator A5065181910 @default.
- W3208287615 creator A5069048014 @default.
- W3208287615 creator A5089976788 @default.
- W3208287615 date "2022-03-01" @default.
- W3208287615 modified "2023-10-14" @default.
- W3208287615 title "Lemur tyrosine kinase 2 silencing inhibits the proliferation of gastric cancer cells by regulating GSK-3β phosphorylation and β-catenin nuclear translocation" @default.
- W3208287615 cites W1620160353 @default.
- W3208287615 cites W1888386056 @default.
- W3208287615 cites W2034269086 @default.
- W3208287615 cites W2047197367 @default.
- W3208287615 cites W2069378448 @default.
- W3208287615 cites W2078371290 @default.
- W3208287615 cites W2079988733 @default.
- W3208287615 cites W2096171021 @default.
- W3208287615 cites W2107277218 @default.
- W3208287615 cites W2122866527 @default.
- W3208287615 cites W2125073574 @default.
- W3208287615 cites W2192080449 @default.
- W3208287615 cites W2276230101 @default.
- W3208287615 cites W2294169416 @default.
- W3208287615 cites W2395032487 @default.
- W3208287615 cites W2404816210 @default.
- W3208287615 cites W2414932745 @default.
- W3208287615 cites W2507219896 @default.
- W3208287615 cites W2567620462 @default.
- W3208287615 cites W2596140032 @default.
- W3208287615 cites W2606704449 @default.
- W3208287615 cites W2761485945 @default.
- W3208287615 cites W2796493152 @default.
- W3208287615 cites W2900224882 @default.
- W3208287615 cites W2917045250 @default.
- W3208287615 cites W2937162507 @default.
- W3208287615 cites W2951091238 @default.
- W3208287615 cites W2965239373 @default.
- W3208287615 cites W2969254388 @default.
- W3208287615 cites W2969765283 @default.
- W3208287615 cites W2981478601 @default.
- W3208287615 cites W2983240420 @default.
- W3208287615 cites W2990586206 @default.
- W3208287615 cites W2990620861 @default.
- W3208287615 cites W2998676941 @default.
- W3208287615 cites W3001475835 @default.
- W3208287615 cites W3008274153 @default.
- W3208287615 cites W3023632151 @default.
- W3208287615 cites W3082676535 @default.
- W3208287615 cites W3094854996 @default.
- W3208287615 cites W3095543163 @default.
- W3208287615 cites W4210990885 @default.
- W3208287615 doi "https://doi.org/10.1080/21655979.2021.1999375" @default.
- W3208287615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34719320" @default.
- W3208287615 hasPublicationYear "2022" @default.
- W3208287615 type Work @default.
- W3208287615 sameAs 3208287615 @default.
- W3208287615 citedByCount "2" @default.
- W3208287615 countsByYear W32082876152022 @default.
- W3208287615 countsByYear W32082876152023 @default.
- W3208287615 crossrefType "journal-article" @default.
- W3208287615 hasAuthorship W3208287615A5010139327 @default.
- W3208287615 hasAuthorship W3208287615A5065181910 @default.
- W3208287615 hasAuthorship W3208287615A5069048014 @default.
- W3208287615 hasAuthorship W3208287615A5089976788 @default.
- W3208287615 hasBestOaLocation W32082876151 @default.
- W3208287615 hasConcept C104317684 @default.
- W3208287615 hasConcept C119056186 @default.
- W3208287615 hasConcept C121608353 @default.
- W3208287615 hasConcept C137620995 @default.
- W3208287615 hasConcept C1491633281 @default.
- W3208287615 hasConcept C153911025 @default.
- W3208287615 hasConcept C173396325 @default.
- W3208287615 hasConcept C185592680 @default.
- W3208287615 hasConcept C29537977 @default.
- W3208287615 hasConcept C30145163 @default.
- W3208287615 hasConcept C502942594 @default.
- W3208287615 hasConcept C54355233 @default.
- W3208287615 hasConcept C55493867 @default.
- W3208287615 hasConcept C62112901 @default.
- W3208287615 hasConcept C62478195 @default.
- W3208287615 hasConcept C81885089 @default.
- W3208287615 hasConcept C86803240 @default.
- W3208287615 hasConcept C95444343 @default.
- W3208287615 hasConcept C96232424 @default.
- W3208287615 hasConceptScore W3208287615C104317684 @default.
- W3208287615 hasConceptScore W3208287615C119056186 @default.
- W3208287615 hasConceptScore W3208287615C121608353 @default.
- W3208287615 hasConceptScore W3208287615C137620995 @default.
- W3208287615 hasConceptScore W3208287615C1491633281 @default.
- W3208287615 hasConceptScore W3208287615C153911025 @default.
- W3208287615 hasConceptScore W3208287615C173396325 @default.
- W3208287615 hasConceptScore W3208287615C185592680 @default.
- W3208287615 hasConceptScore W3208287615C29537977 @default.
- W3208287615 hasConceptScore W3208287615C30145163 @default.
- W3208287615 hasConceptScore W3208287615C502942594 @default.
- W3208287615 hasConceptScore W3208287615C54355233 @default.
- W3208287615 hasConceptScore W3208287615C55493867 @default.
- W3208287615 hasConceptScore W3208287615C62112901 @default.