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- W3208292419 abstract "Abstract Precise control of gene expression during differentiation relies on the interplay of chromatin and nuclear structure. Despite an established contribution of nuclear membrane proteins to developmental gene regulation, little is known regarding the role of inner nuclear proteins. Here we demonstrate that loss of the nuclear scaffolding protein Matrin-3 (Matr3) in erythroid cells leads to morphological and gene expression changes characteristic of accelerated maturation, as well as broad alterations in chromatin organization similar to those accompanying differentiation. Matr3 protein interacts with CTCF and the cohesin complex, and its loss perturbs their occupancy at a subset of sites. Destabilization of CTCF and cohesin binding correlates with altered transcription and accelerated differentiation. This association is conserved in embryonic stem cells. Our findings indicate Matr3 negatively affects cell fate transitions and demonstrate that a critical inner nuclear protein impacts occupancy of architectural factors, culminating in broad effects on chromatin organization and cell differentiation." @default.
- W3208292419 created "2021-11-08" @default.
- W3208292419 creator A5008408386 @default.
- W3208292419 creator A5015049136 @default.
- W3208292419 creator A5038587862 @default.
- W3208292419 creator A5038851202 @default.
- W3208292419 creator A5048066309 @default.
- W3208292419 creator A5063080853 @default.
- W3208292419 creator A5079784932 @default.
- W3208292419 creator A5083543522 @default.
- W3208292419 creator A5086682837 @default.
- W3208292419 creator A5087512796 @default.
- W3208292419 creator A5088119941 @default.
- W3208292419 date "2021-10-29" @default.
- W3208292419 modified "2023-10-16" @default.
- W3208292419 title "Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture" @default.
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