FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208315063> ?p ?o ?g. }

• W3208315063 endingPage "18311" @default.
• W3208315063 startingPage "18305" @default.
• W3208315063 abstract "The formation of ordered protein and peptide assemblies is a phenomenon related to a wide range of human diseases. However, the mechanism of assembly at the molecular level remains largely unknown. Minimal models enable the exploration of the underlying interactions that are at the core of such self-assembly processes. In particular, the ability of phenylalanine, a single aromatic amino acid, to form an amyloid-like structure has challenged the previous dogma viewing a peptide backbone as a prerequisite for assembly. The driving forces controlling the nucleation and assembly in the absence of a peptide backbone remain to be identified. Here, aiming to unravel these forces, we explored the kinetics and thermodynamics of three phenylalanine-containing molecules during their assembly process: the amino acid phenylalanine, which accumulates in phenylketonuria patients, the diphenylalanine core-motif of the amyloid β peptide related to Alzheimer's disease, and the extended triphenylalanine peptide which forms a range of distinct nanostructures in vitro. We found that the aggregation propensity, regarding the critical monomer concentration, strongly increases with size, with triphenylalanine being the most aggregation-prone species under our experimental conditions. In the context of classical nucleation theory, this increase in aggregation propensity can be attributed to the larger free energy decrease upon aggregation of larger peptides and is not due to the presence/absence of a peptide bond per se. Taken together, this work provides insights into the aggregation processes of chemically simple systems and suggests that both backbone-containing peptides and backbone-lacking amino acids assemble through a similar mechanism, thus supporting the classification of amino acids in the continuum of amyloid-forming building blocks." @default.
• W3208315063 created "2021-11-08" @default.
• W3208315063 creator A5015741024 @default.
• W3208315063 creator A5027274327 @default.
• W3208315063 creator A5041530719 @default.
• W3208315063 creator A5064936958 @default.
• W3208315063 creator A5073086936 @default.
• W3208315063 creator A5081058474 @default.
• W3208315063 creator A5082716768 @default.
• W3208315063 date "2021-10-25" @default.
• W3208315063 modified "2023-10-06" @default.
• W3208315063 title "Kinetic and Thermodynamic Driving Factors in the Assembly of Phenylalanine-Based Modules" @default.
• W3208315063 cites W1544926311 @default.
• W3208315063 cites W1969057447 @default.
• W3208315063 cites W1969744652 @default.
• W3208315063 cites W1970795995 @default.
• W3208315063 cites W2007236469 @default.
• W3208315063 cites W2007789323 @default.
• W3208315063 cites W2013455144 @default.
• W3208315063 cites W2019800481 @default.
• W3208315063 cites W2030325989 @default.
• W3208315063 cites W2043259878 @default.
• W3208315063 cites W2057153496 @default.
• W3208315063 cites W2061657038 @default.
• W3208315063 cites W2063827082 @default.
• W3208315063 cites W2065248623 @default.
• W3208315063 cites W2070682452 @default.
• W3208315063 cites W2072239449 @default.
• W3208315063 cites W2081287450 @default.
• W3208315063 cites W2084111645 @default.
• W3208315063 cites W2094881767 @default.
• W3208315063 cites W2148841303 @default.
• W3208315063 cites W2165186407 @default.
• W3208315063 cites W2171413096 @default.
• W3208315063 cites W2225657959 @default.
• W3208315063 cites W2313968004 @default.
• W3208315063 cites W2316345344 @default.
• W3208315063 cites W2330026229 @default.
• W3208315063 cites W2418796299 @default.
• W3208315063 cites W2550308267 @default.
• W3208315063 cites W2603399854 @default.
• W3208315063 cites W2612522476 @default.
• W3208315063 cites W2752089475 @default.
• W3208315063 cites W2752260203 @default.
• W3208315063 cites W2761555546 @default.
• W3208315063 cites W2761810763 @default.
• W3208315063 cites W2799799648 @default.
• W3208315063 cites W2804957616 @default.
• W3208315063 cites W2808474736 @default.
• W3208315063 cites W2887445075 @default.
• W3208315063 cites W2997797045 @default.
• W3208315063 cites W3007781343 @default.
• W3208315063 cites W3012255313 @default.
• W3208315063 cites W3016619543 @default.
• W3208315063 cites W3099036111 @default.
• W3208315063 cites W3117681407 @default.
• W3208315063 cites W4206721391 @default.
• W3208315063 cites W4230321861 @default.
• W3208315063 cites W4249791806 @default.
• W3208315063 cites W4255369060 @default.
• W3208315063 doi "https://doi.org/10.1021/acsnano.1c07537" @default.
• W3208315063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34694771" @default.
• W3208315063 hasPublicationYear "2021" @default.
• W3208315063 type Work @default.
• W3208315063 sameAs 3208315063 @default.
• W3208315063 citedByCount "12" @default.
• W3208315063 countsByYear W32083150632022 @default.
• W3208315063 countsByYear W32083150632023 @default.
• W3208315063 crossrefType "journal-article" @default.
• W3208315063 hasAuthorship W3208315063A5015741024 @default.
• W3208315063 hasAuthorship W3208315063A5027274327 @default.
• W3208315063 hasAuthorship W3208315063A5041530719 @default.
• W3208315063 hasAuthorship W3208315063A5064936958 @default.
• W3208315063 hasAuthorship W3208315063A5073086936 @default.
• W3208315063 hasAuthorship W3208315063A5081058474 @default.
• W3208315063 hasAuthorship W3208315063A5082716768 @default.
• W3208315063 hasBestOaLocation W32083150632 @default.
• W3208315063 hasConcept C12554922 @default.
• W3208315063 hasConcept C151730666 @default.
• W3208315063 hasConcept C166940927 @default.
• W3208315063 hasConcept C178790620 @default.
• W3208315063 hasConcept C185592680 @default.
• W3208315063 hasConcept C2777431362 @default.
• W3208315063 hasConcept C2779281246 @default.
• W3208315063 hasConcept C2779343474 @default.
• W3208315063 hasConcept C32909587 @default.
• W3208315063 hasConcept C515207424 @default.
• W3208315063 hasConcept C521977710 @default.
• W3208315063 hasConcept C55493867 @default.
• W3208315063 hasConcept C61048295 @default.
• W3208315063 hasConcept C71240020 @default.
• W3208315063 hasConcept C86803240 @default.
• W3208315063 hasConceptScore W3208315063C12554922 @default.
• W3208315063 hasConceptScore W3208315063C151730666 @default.
• W3208315063 hasConceptScore W3208315063C166940927 @default.
• W3208315063 hasConceptScore W3208315063C178790620 @default.
• W3208315063 hasConceptScore W3208315063C185592680 @default.
• W3208315063 hasConceptScore W3208315063C2777431362 @default.

• next