Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208347687> ?p ?o ?g. }
- W3208347687 endingPage "525" @default.
- W3208347687 startingPage "515" @default.
- W3208347687 abstract "Cell signaling mediated by the KIT receptor is critical for many aspects of oogenesis including the proliferation and migration of primordial germ cells, as well as the survival, growth, and maturation of ovarian follicles. We previously showed that KIT regulates cyst breakdown and primordial follicle formation, and in this study, have investigated the mechanisms downstream of the receptor by modulating the activity of two downstream signaling cascades: the phosphoinositide 3-kinase (PI3K) and the mitogen-activated protein kinase pathways. E17.5 ovaries were cultured for 5 days with a daily dose of media supplemented with either the PI3K inhibitor LY294002, the MEK inhibitor U0126, or a DMSO vehicle control. Our histological observations aligned with the established role of PI3K in oocyte growth and primordial follicle activation but also revealed that LY294002 treatment delayed the processes of cyst breakdown and primordial follicle formation. U0126 treatment also led to a reduction in oocyte growth and follicle development but did not appear to affect cyst breakdown. The delay in cyst breakdown was mitigated when ovaries were dually dosed with LY294002 and KITL, suggesting that while KIT may signal through PI3K to promote cyst breakdown, other signaling networks downstream of the receptor could compensate. These observations unearth a role for PI3K signaling in the establishment of the ovarian reserve and suggest that PI3K might be the primary mediator of KIT-induced cyst breakdown and primordial follicle formation in the mouse ovary." @default.
- W3208347687 created "2021-11-08" @default.
- W3208347687 creator A5015537905 @default.
- W3208347687 creator A5023927988 @default.
- W3208347687 creator A5049386472 @default.
- W3208347687 date "2021-11-01" @default.
- W3208347687 modified "2023-10-17" @default.
- W3208347687 title "Regulation of mouse primordial follicle formation by signaling through the PI3K pathway" @default.
- W3208347687 cites W1482574930 @default.
- W3208347687 cites W1822242100 @default.
- W3208347687 cites W1829371983 @default.
- W3208347687 cites W1934287581 @default.
- W3208347687 cites W1965695331 @default.
- W3208347687 cites W1966188866 @default.
- W3208347687 cites W1976321898 @default.
- W3208347687 cites W1989027475 @default.
- W3208347687 cites W1989753106 @default.
- W3208347687 cites W1996634627 @default.
- W3208347687 cites W1997667024 @default.
- W3208347687 cites W2000167648 @default.
- W3208347687 cites W2013313016 @default.
- W3208347687 cites W2014243263 @default.
- W3208347687 cites W2020866505 @default.
- W3208347687 cites W2021180320 @default.
- W3208347687 cites W2028415754 @default.
- W3208347687 cites W2030656510 @default.
- W3208347687 cites W2035134361 @default.
- W3208347687 cites W2037695813 @default.
- W3208347687 cites W2038725702 @default.
- W3208347687 cites W2041312799 @default.
- W3208347687 cites W2043396979 @default.
- W3208347687 cites W2044203359 @default.
- W3208347687 cites W2046283103 @default.
- W3208347687 cites W2050395183 @default.
- W3208347687 cites W2059844002 @default.
- W3208347687 cites W2063436204 @default.
- W3208347687 cites W2071040218 @default.
- W3208347687 cites W2074113757 @default.
- W3208347687 cites W2076947916 @default.
- W3208347687 cites W2080823336 @default.
- W3208347687 cites W2085679334 @default.
- W3208347687 cites W2096282502 @default.
- W3208347687 cites W2098344682 @default.
- W3208347687 cites W2105505249 @default.
- W3208347687 cites W2105858725 @default.
- W3208347687 cites W2107705298 @default.
- W3208347687 cites W2112811492 @default.
- W3208347687 cites W2125564527 @default.
- W3208347687 cites W2138023493 @default.
- W3208347687 cites W2139417605 @default.
- W3208347687 cites W2144089726 @default.
- W3208347687 cites W2147629399 @default.
- W3208347687 cites W2151900782 @default.
- W3208347687 cites W2152594753 @default.
- W3208347687 cites W2168056910 @default.
- W3208347687 cites W2171196817 @default.
- W3208347687 cites W2172160601 @default.
- W3208347687 cites W2182720429 @default.
- W3208347687 cites W2311625697 @default.
- W3208347687 cites W2313999212 @default.
- W3208347687 cites W2425569665 @default.
- W3208347687 cites W2509202459 @default.
- W3208347687 cites W2567345748 @default.
- W3208347687 cites W2587517962 @default.
- W3208347687 cites W2588557803 @default.
- W3208347687 cites W2589910211 @default.
- W3208347687 cites W2764473259 @default.
- W3208347687 cites W2771867042 @default.
- W3208347687 cites W2892989873 @default.
- W3208347687 cites W2893171128 @default.
- W3208347687 cites W2914133736 @default.
- W3208347687 cites W3006007736 @default.
- W3208347687 cites W3024993730 @default.
- W3208347687 cites W4211075026 @default.
- W3208347687 doi "https://doi.org/10.1093/biolre/ioab204" @default.
- W3208347687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34725674" @default.
- W3208347687 hasPublicationYear "2021" @default.
- W3208347687 type Work @default.
- W3208347687 sameAs 3208347687 @default.
- W3208347687 citedByCount "6" @default.
- W3208347687 countsByYear W32083476872022 @default.
- W3208347687 countsByYear W32083476872023 @default.
- W3208347687 crossrefType "journal-article" @default.
- W3208347687 hasAuthorship W3208347687A5015537905 @default.
- W3208347687 hasAuthorship W3208347687A5023927988 @default.
- W3208347687 hasAuthorship W3208347687A5049386472 @default.
- W3208347687 hasBestOaLocation W32083476872 @default.
- W3208347687 hasConcept C102570824 @default.
- W3208347687 hasConcept C126322002 @default.
- W3208347687 hasConcept C134018914 @default.
- W3208347687 hasConcept C196843134 @default.
- W3208347687 hasConcept C2776690073 @default.
- W3208347687 hasConcept C2776912716 @default.
- W3208347687 hasConcept C2778324911 @default.
- W3208347687 hasConcept C2780536345 @default.
- W3208347687 hasConcept C5512455 @default.
- W3208347687 hasConcept C62478195 @default.
- W3208347687 hasConcept C71924100 @default.