FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208352214> ?p ?o ?g. }

• W3208352214 abstract "Kashin-Beck disease (KBD) is a severe osteochondral disorder that may be driven by the interaction between genetic and environmental factors. We aimed to improve our understanding of the gut microbiota structure in KBD patients of different grades and the relationship between the gut microbiota and serum metabolites. Fecal and serum samples collected from KBD patients and normal controls (NCs) were used to characterize the gut microbiota using 16S rDNA gene and metabolomic sequencing via liquid chromatography-mass spectrometry (LC/MS). To identify whether gut microbial changes at the species level are associated with the genes or functions of the gut bacteria in the KBD patients, metagenomic sequencing of fecal samples from grade I KBD, grade II KBD and NC subjects was performed. The KBD group was characterized by elevated levels of Fusobacteria and Bacteroidetes. A total of 56 genera were identified to be significantly differentially abundant between the two groups. The genera Alloprevotella, Robinsoniella, Megamonas, and Escherichia_Shigella were more abundant in the KBD group. Consistent with the 16S rDNA analysis at the genus level, most of the differentially abundant species in KBD subjects belonged to the genus Prevotella according to metagenomic sequencing. Serum metabolomic analysis identified some differentially abundant metabolites among the grade I and II KBD and NC groups that were involved in lipid metabolism metabolic networks, such as that for unsaturated fatty acids and glycerophospholipids. Furthermore, we found that these differences in metabolite levels were associated with altered abundances of specific species. Our study provides a comprehensive landscape of the gut microbiota and metabolites in KBD patients and provides substantial evidence of a novel interplay between the gut microbiome and metabolome in KBD pathogenesis." @default.
• W3208352214 created "2021-11-08" @default.
• W3208352214 creator A5000300628 @default.
• W3208352214 creator A5012764858 @default.
• W3208352214 creator A5015662696 @default.
• W3208352214 creator A5022598327 @default.
• W3208352214 creator A5037881165 @default.
• W3208352214 creator A5040606464 @default.
• W3208352214 creator A5041148728 @default.
• W3208352214 creator A5064860015 @default.
• W3208352214 creator A5077068949 @default.
• W3208352214 creator A5083270645 @default.
• W3208352214 creator A5083767492 @default.
• W3208352214 creator A5091495004 @default.
• W3208352214 date "2021-10-28" @default.
• W3208352214 modified "2023-10-15" @default.
• W3208352214 title "Alterations in the gut microbiota and metabolite profiles of patients with Kashin-Beck disease, an endemic osteoarthritis in China" @default.
• W3208352214 cites W1533313469 @default.
• W3208352214 cites W1551485069 @default.
• W3208352214 cites W1964010911 @default.
• W3208352214 cites W1966447562 @default.
• W3208352214 cites W1978864283 @default.
• W3208352214 cites W1979383236 @default.
• W3208352214 cites W1997062226 @default.
• W3208352214 cites W2008930714 @default.
• W3208352214 cites W2012606594 @default.
• W3208352214 cites W2016300495 @default.
• W3208352214 cites W2027504173 @default.
• W3208352214 cites W2032125969 @default.
• W3208352214 cites W2032230795 @default.
• W3208352214 cites W2034950379 @default.
• W3208352214 cites W2048816129 @default.
• W3208352214 cites W2059996143 @default.
• W3208352214 cites W2064399682 @default.
• W3208352214 cites W2066186499 @default.
• W3208352214 cites W2075180304 @default.
• W3208352214 cites W2078240794 @default.
• W3208352214 cites W2079459227 @default.
• W3208352214 cites W2092122072 @default.
• W3208352214 cites W2100463095 @default.
• W3208352214 cites W2104307350 @default.
• W3208352214 cites W2112343280 @default.
• W3208352214 cites W2136500114 @default.
• W3208352214 cites W2152089866 @default.
• W3208352214 cites W2153832854 @default.
• W3208352214 cites W2164778714 @default.
• W3208352214 cites W2169364567 @default.
• W3208352214 cites W2198125811 @default.
• W3208352214 cites W2228687373 @default.
• W3208352214 cites W2414147425 @default.
• W3208352214 cites W2469187072 @default.
• W3208352214 cites W2486332948 @default.
• W3208352214 cites W2518510778 @default.
• W3208352214 cites W2560458673 @default.
• W3208352214 cites W2599610907 @default.
• W3208352214 cites W2737111625 @default.
• W3208352214 cites W2754300721 @default.
• W3208352214 cites W2764276208 @default.
• W3208352214 cites W2766405997 @default.
• W3208352214 cites W2767894846 @default.
• W3208352214 cites W2774437822 @default.
• W3208352214 cites W2775356757 @default.
• W3208352214 cites W2778082937 @default.
• W3208352214 cites W2792269412 @default.
• W3208352214 cites W2889967749 @default.
• W3208352214 cites W2900697674 @default.
• W3208352214 cites W2909668868 @default.
• W3208352214 cites W2921108593 @default.
• W3208352214 cites W2949291166 @default.
• W3208352214 cites W2982102540 @default.
• W3208352214 cites W3007742112 @default.
• W3208352214 cites W3034977328 @default.
• W3208352214 cites W3048121804 @default.
• W3208352214 doi "https://doi.org/10.1038/s41419-021-04322-2" @default.
• W3208352214 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8553765" @default.
• W3208352214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34711812" @default.
• W3208352214 hasPublicationYear "2021" @default.
• W3208352214 type Work @default.
• W3208352214 sameAs 3208352214 @default.
• W3208352214 citedByCount "8" @default.
• W3208352214 countsByYear W32083522142022 @default.
• W3208352214 countsByYear W32083522142023 @default.
• W3208352214 crossrefType "journal-article" @default.
• W3208352214 hasAuthorship W3208352214A5000300628 @default.
• W3208352214 hasAuthorship W3208352214A5012764858 @default.
• W3208352214 hasAuthorship W3208352214A5015662696 @default.
• W3208352214 hasAuthorship W3208352214A5022598327 @default.
• W3208352214 hasAuthorship W3208352214A5037881165 @default.
• W3208352214 hasAuthorship W3208352214A5040606464 @default.
• W3208352214 hasAuthorship W3208352214A5041148728 @default.
• W3208352214 hasAuthorship W3208352214A5064860015 @default.
• W3208352214 hasAuthorship W3208352214A5077068949 @default.
• W3208352214 hasAuthorship W3208352214A5083270645 @default.
• W3208352214 hasAuthorship W3208352214A5083767492 @default.
• W3208352214 hasAuthorship W3208352214A5091495004 @default.
• W3208352214 hasBestOaLocation W32083522141 @default.
• W3208352214 hasConcept C104317684 @default.
• W3208352214 hasConcept C135870905 @default.
• W3208352214 hasConcept C143121216 @default.
• W3208352214 hasConcept C15151743 @default.

• next