FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208352702> ?p ?o ?g. }

• W3208352702 endingPage "166" @default.
• W3208352702 startingPage "158" @default.
• W3208352702 abstract "TIA-1 (T cell restricted intracellular antigen-1) is a kind of RNA-binding protein which serves as the downstream of CED-9 (a BCL2 homolog) and induces apoptosis under stress conditions. So far, the function of apoptosis mediated by TIA-1 has been extensively studied in higher animals, and apoptosis happens to be related to biological immune defense. However, the involvement of TIA-1 in the study of immune function during viral infection has not been clearly studied, especially in marine invertebrates. In the study, SpTIA-1 in mud crab (Scylla paramamosain) was specifically identified. The Open Reading Frame (ORF) of SpTIA-1 was consisted of 1116 nucleotide bases and encoded 372 amino acids. Besides, the results showed that the expression of SpTIA-1 was obviously up-regulated during WSSV (White Spot Syndrome Virus) infection in hemocytes of mud crab. Furthermore, through RNAi approach, we found that SpTIA-1 could activate Caspase-3 signaling and increase ROS levels to reduce mitochondrial membrane potential, resulting in the increase of apoptosis rate in hemocytes, which eventually suppressed WSSV multiplication in mud crab. The current study therefore improves the knowledge of antiviral immunity in mud crab and provides new insights into the innate immunity of marine crustaceans." @default.
• W3208352702 created "2021-11-08" @default.
• W3208352702 creator A5036035882 @default.
• W3208352702 creator A5038349585 @default.
• W3208352702 creator A5040893636 @default.
• W3208352702 creator A5069815282 @default.
• W3208352702 creator A5080667640 @default.
• W3208352702 date "2021-12-01" @default.
• W3208352702 modified "2023-10-18" @default.
• W3208352702 title "SpTIA-1 suppresses WSSV infection by promoting apoptosis in mud crab (Scylla paramamosain)" @default.
• W3208352702 cites W1500228509 @default.
• W3208352702 cites W1589201760 @default.
• W3208352702 cites W1603718291 @default.
• W3208352702 cites W1745634660 @default.
• W3208352702 cites W1880018678 @default.
• W3208352702 cites W1964072966 @default.
• W3208352702 cites W1975153732 @default.
• W3208352702 cites W1977755970 @default.
• W3208352702 cites W1987374983 @default.
• W3208352702 cites W1997068693 @default.
• W3208352702 cites W2009448733 @default.
• W3208352702 cites W2021074776 @default.
• W3208352702 cites W2025822353 @default.
• W3208352702 cites W2036411709 @default.
• W3208352702 cites W2039086039 @default.
• W3208352702 cites W2060222040 @default.
• W3208352702 cites W2060865344 @default.
• W3208352702 cites W2069877113 @default.
• W3208352702 cites W2087877138 @default.
• W3208352702 cites W2089734938 @default.
• W3208352702 cites W2098387574 @default.
• W3208352702 cites W2112015968 @default.
• W3208352702 cites W2115282694 @default.
• W3208352702 cites W2122028337 @default.
• W3208352702 cites W2131868763 @default.
• W3208352702 cites W2138651252 @default.
• W3208352702 cites W2144701362 @default.
• W3208352702 cites W2149541702 @default.
• W3208352702 cites W2156817602 @default.
• W3208352702 cites W2171674055 @default.
• W3208352702 cites W2621992031 @default.
• W3208352702 cites W2755322677 @default.
• W3208352702 cites W2766463143 @default.
• W3208352702 cites W2794241481 @default.
• W3208352702 cites W2936373618 @default.
• W3208352702 cites W2955441600 @default.
• W3208352702 doi "https://doi.org/10.1016/j.molimm.2021.10.015" @default.
• W3208352702 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34715578" @default.
• W3208352702 hasPublicationYear "2021" @default.
• W3208352702 type Work @default.
• W3208352702 sameAs 3208352702 @default.
• W3208352702 citedByCount "3" @default.
• W3208352702 countsByYear W32083527022023 @default.
• W3208352702 crossrefType "journal-article" @default.
• W3208352702 hasAuthorship W3208352702A5036035882 @default.
• W3208352702 hasAuthorship W3208352702A5038349585 @default.
• W3208352702 hasAuthorship W3208352702A5040893636 @default.
• W3208352702 hasAuthorship W3208352702A5069815282 @default.
• W3208352702 hasAuthorship W3208352702A5080667640 @default.
• W3208352702 hasConcept C104317684 @default.
• W3208352702 hasConcept C136449434 @default.
• W3208352702 hasConcept C159047783 @default.
• W3208352702 hasConcept C167625842 @default.
• W3208352702 hasConcept C18903297 @default.
• W3208352702 hasConcept C190283241 @default.
• W3208352702 hasConcept C203014093 @default.
• W3208352702 hasConcept C2522874641 @default.
• W3208352702 hasConcept C2778595701 @default.
• W3208352702 hasConcept C2779341262 @default.
• W3208352702 hasConcept C2779771762 @default.
• W3208352702 hasConcept C2780710107 @default.
• W3208352702 hasConcept C47289529 @default.
• W3208352702 hasConcept C55493867 @default.
• W3208352702 hasConcept C79879829 @default.
• W3208352702 hasConcept C84766238 @default.
• W3208352702 hasConcept C86803240 @default.
• W3208352702 hasConcept C8891405 @default.
• W3208352702 hasConcept C89423630 @default.
• W3208352702 hasConcept C95444343 @default.
• W3208352702 hasConceptScore W3208352702C104317684 @default.
• W3208352702 hasConceptScore W3208352702C136449434 @default.
• W3208352702 hasConceptScore W3208352702C159047783 @default.
• W3208352702 hasConceptScore W3208352702C167625842 @default.
• W3208352702 hasConceptScore W3208352702C18903297 @default.
• W3208352702 hasConceptScore W3208352702C190283241 @default.
• W3208352702 hasConceptScore W3208352702C203014093 @default.
• W3208352702 hasConceptScore W3208352702C2522874641 @default.
• W3208352702 hasConceptScore W3208352702C2778595701 @default.
• W3208352702 hasConceptScore W3208352702C2779341262 @default.
• W3208352702 hasConceptScore W3208352702C2779771762 @default.
• W3208352702 hasConceptScore W3208352702C2780710107 @default.
• W3208352702 hasConceptScore W3208352702C47289529 @default.
• W3208352702 hasConceptScore W3208352702C55493867 @default.
• W3208352702 hasConceptScore W3208352702C79879829 @default.
• W3208352702 hasConceptScore W3208352702C84766238 @default.
• W3208352702 hasConceptScore W3208352702C86803240 @default.
• W3208352702 hasConceptScore W3208352702C8891405 @default.
• W3208352702 hasConceptScore W3208352702C89423630 @default.

• next