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- W3208360054 abstract "In this case report the potential drug-drug interaction between cytochrome P450 (CYP) 3A4 substrates tezacaftor-ivacaftor and CYP3A4/5 inhibitor clofazimine is investigated in a patient with cystic fibrosis. Exposure to tezacaftor, ivacaftor and its metabolites was assessed by determination of the area under the plasma concentration versus time curve (AUC0-24 h for tezacaftor and AUC0-12 h for ivacaftor and its metabolite) before start of clofazimine and 8 and 115 days after start of clofazimine. The AUC-ratio at day 115 and pre-start was 1.09, 1.45 and 0.747 for ivacaftor, hydroxymethyl ivacaftor and tezacaftor, respectively. This case suggests that clofazimine exhibits no clinically relevant increase in exposure to tezacaftor and ivacaftor." @default.
- W3208360054 created "2021-11-08" @default.
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- W3208360054 date "2022-01-01" @default.
- W3208360054 modified "2023-10-13" @default.
- W3208360054 title "No drug-drug interaction between tezacaftor-ivacaftor and clofazimine: A case report" @default.
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- W3208360054 doi "https://doi.org/10.1016/j.jcf.2021.10.003" @default.
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