FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208361105> ?p ?o ?g. }

• W3208361105 abstract "Abstract Background Mosquito-borne dengue virus (DENV) causes major disease worldwide, impacting 50–100 million people every year, and is spread by the major mosquito vector Aedes aegypti . Understanding mosquito physiology, including antiviral mechanisms, and developing new control strategies have become an important step towards the elimination of DENV disease. In the study reported here, we focused on autophagy, a pathway suggested as having a positive influence on virus replication in humans, as a potential antiviral target in the mosquito. Methods To understand the role played by autophagy in Ae. aegypti , we examined the activation of this pathway in Aag-2 cells, an Ae. aegypti -derived cell line, infected with DENV. Rapamycin and 3-methyladenine, two small molecules that have been shown to affect the function of the autophagy pathway, were used to activate or suppress, respectively, the autophagy pathway. Results At 1-day post-DENV infection in Aag-2 cells, transcript levels of both the microtubule-associated protein light chain 3-phosphatidylethanolamine conjugate (LC3-II) and autophagy-related protein 1 (ATG1) increased. Rapamycin treatment activated the autophagy pathway as early as 1-h post-treatment, and the virus titer had decreased in the Aag-2 cells at 2 days post-infection; in contrast, the 3-methyladenine treatment did not significantly affect the DENV titer. Treatment with these small molecules also impacted the ATG12 transcript levels in DENV-infected cells. Conclusions Our studies revealed that activation of the autophagy pathway through rapamycin treatment altered DENV infection in the mosquito cells, suggesting that this pathway could be a possible antiviral mechanism in the mosquito system. Here we provide fundamental information needed to proceed with future experiments and to improve our understanding of the mosquito’s immune response against DENV. Graphical Abstract" @default.
• W3208361105 created "2021-11-08" @default.
• W3208361105 creator A5011197498 @default.
• W3208361105 creator A5047430621 @default.
• W3208361105 date "2021-10-26" @default.
• W3208361105 modified "2023-10-14" @default.
• W3208361105 title "Activation of the autophagy pathway decreases dengue virus infection in Aedes aegypti cells" @default.
• W3208361105 cites W1969339170 @default.
• W3208361105 cites W1975050610 @default.
• W3208361105 cites W1979917788 @default.
• W3208361105 cites W1987566410 @default.
• W3208361105 cites W2001591494 @default.
• W3208361105 cites W2005111050 @default.
• W3208361105 cites W2011080716 @default.
• W3208361105 cites W2011485783 @default.
• W3208361105 cites W2018750823 @default.
• W3208361105 cites W2028543716 @default.
• W3208361105 cites W2031277784 @default.
• W3208361105 cites W2034964406 @default.
• W3208361105 cites W2036712227 @default.
• W3208361105 cites W2038994786 @default.
• W3208361105 cites W2043825222 @default.
• W3208361105 cites W2044525934 @default.
• W3208361105 cites W2052104837 @default.
• W3208361105 cites W2065031087 @default.
• W3208361105 cites W2070993664 @default.
• W3208361105 cites W2075614768 @default.
• W3208361105 cites W2085030395 @default.
• W3208361105 cites W2085470568 @default.
• W3208361105 cites W2086079196 @default.
• W3208361105 cites W2087920955 @default.
• W3208361105 cites W2088787651 @default.
• W3208361105 cites W2092956992 @default.
• W3208361105 cites W2094503313 @default.
• W3208361105 cites W2097600311 @default.
• W3208361105 cites W2108086395 @default.
• W3208361105 cites W2111025081 @default.
• W3208361105 cites W2113432343 @default.
• W3208361105 cites W2118195172 @default.
• W3208361105 cites W2119557656 @default.
• W3208361105 cites W2126789944 @default.
• W3208361105 cites W2131007152 @default.
• W3208361105 cites W2141165347 @default.
• W3208361105 cites W2148281700 @default.
• W3208361105 cites W2159754384 @default.
• W3208361105 cites W2164778558 @default.
• W3208361105 cites W2289342211 @default.
• W3208361105 cites W2309536261 @default.
• W3208361105 cites W2465759754 @default.
• W3208361105 cites W2474086775 @default.
• W3208361105 cites W2772021067 @default.
• W3208361105 cites W2781785776 @default.
• W3208361105 cites W2888469123 @default.
• W3208361105 cites W3027945677 @default.
• W3208361105 cites W3120148921 @default.
• W3208361105 cites W3130554406 @default.
• W3208361105 cites W4247904703 @default.
• W3208361105 doi "https://doi.org/10.1186/s13071-021-05066-w" @default.
• W3208361105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8549150" @default.
• W3208361105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34702321" @default.
• W3208361105 hasPublicationYear "2021" @default.
• W3208361105 type Work @default.
• W3208361105 sameAs 3208361105 @default.
• W3208361105 citedByCount "7" @default.
• W3208361105 countsByYear W32083611052022 @default.
• W3208361105 countsByYear W32083611052023 @default.
• W3208361105 crossrefType "journal-article" @default.
• W3208361105 hasAuthorship W3208361105A5011197498 @default.
• W3208361105 hasAuthorship W3208361105A5047430621 @default.
• W3208361105 hasBestOaLocation W32083611051 @default.
• W3208361105 hasConcept C140704245 @default.
• W3208361105 hasConcept C159047783 @default.
• W3208361105 hasConcept C173758957 @default.
• W3208361105 hasConcept C190283241 @default.
• W3208361105 hasConcept C203522944 @default.
• W3208361105 hasConcept C2522874641 @default.
• W3208361105 hasConcept C2777775583 @default.
• W3208361105 hasConcept C2779635636 @default.
• W3208361105 hasConcept C2780688631 @default.
• W3208361105 hasConcept C533803919 @default.
• W3208361105 hasConcept C54355233 @default.
• W3208361105 hasConcept C59822182 @default.
• W3208361105 hasConcept C86803240 @default.
• W3208361105 hasConcept C89138240 @default.
• W3208361105 hasConcept C95444343 @default.
• W3208361105 hasConceptScore W3208361105C140704245 @default.
• W3208361105 hasConceptScore W3208361105C159047783 @default.
• W3208361105 hasConceptScore W3208361105C173758957 @default.
• W3208361105 hasConceptScore W3208361105C190283241 @default.
• W3208361105 hasConceptScore W3208361105C203522944 @default.
• W3208361105 hasConceptScore W3208361105C2522874641 @default.
• W3208361105 hasConceptScore W3208361105C2777775583 @default.
• W3208361105 hasConceptScore W3208361105C2779635636 @default.
• W3208361105 hasConceptScore W3208361105C2780688631 @default.
• W3208361105 hasConceptScore W3208361105C533803919 @default.
• W3208361105 hasConceptScore W3208361105C54355233 @default.
• W3208361105 hasConceptScore W3208361105C59822182 @default.
• W3208361105 hasConceptScore W3208361105C86803240 @default.
• W3208361105 hasConceptScore W3208361105C89138240 @default.
• W3208361105 hasConceptScore W3208361105C95444343 @default.

• next