Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208362461> ?p ?o ?g. }
- W3208362461 abstract "Bacterial cancer therapy (BCT) shows great promise for treatment of solid tumors, yet basic mechanisms of bacterial-induced tumor suppression remain undefined. Attenuated strains of Salmonella enterica serovar Typhimurium (STm) have commonly been used in mouse models of BCT in xenograft and orthotopic transplant cancer models. We aimed to better understand the tumor epithelium-targeted mechanisms of BCT by using autochthonous mouse models of intestinal cancer and tumor organoid cultures to assess the effectiveness and consequences of oral treatment with aromatase A-deficient STm (STmΔaroA). STmΔaroA delivered by oral gavage significantly reduced tumor burden and tumor load in both a colitis-associated colorectal cancer (CAC) model and in a spontaneous Apcmin/+ intestinal cancer model. STmΔaroA colonization of tumors caused alterations in transcription of mRNAs associated with tumor stemness, epithelial-mesenchymal transition, and cell cycle. Metabolomic analysis of tumors demonstrated alteration in the metabolic environment of STmΔaroA-treated tumors, suggesting that STmΔaroA imposes metabolic competition on the tumor. Use of tumor organoid cultures in vitro recapitulated effects seen on tumor stemness, mesenchymal markers, and altered metabolome. Furthermore, live STmΔaroA was required, demonstrating active mechanisms including metabolite usage. We have demonstrated that oral BCT is efficacious in autochthonous intestinal cancer models, that BCT imposes metabolic competition, and that BCT has direct effects on the tumor epithelium affecting tumor stem cells." @default.
- W3208362461 created "2021-11-08" @default.
- W3208362461 creator A5001054225 @default.
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- W3208362461 date "2021-10-28" @default.
- W3208362461 modified "2023-10-13" @default.
- W3208362461 title "Bacterial cancer therapy in autochthonous colorectal cancer affects tumor growth and metabolic landscape" @default.
- W3208362461 cites W1483496013 @default.
- W3208362461 cites W1501404116 @default.
- W3208362461 cites W1510865194 @default.
- W3208362461 cites W1569874913 @default.
- W3208362461 cites W1964065596 @default.
- W3208362461 cites W1970051637 @default.
- W3208362461 cites W1976327004 @default.
- W3208362461 cites W1979507175 @default.
- W3208362461 cites W1984760857 @default.
- W3208362461 cites W1994232345 @default.
- W3208362461 cites W1995097523 @default.
- W3208362461 cites W1998507492 @default.
- W3208362461 cites W2002513358 @default.
- W3208362461 cites W2009770467 @default.
- W3208362461 cites W2015784141 @default.
- W3208362461 cites W2026471860 @default.
- W3208362461 cites W2030915253 @default.
- W3208362461 cites W2036496674 @default.
- W3208362461 cites W2042048278 @default.
- W3208362461 cites W2046328216 @default.
- W3208362461 cites W2077530057 @default.
- W3208362461 cites W2077631278 @default.
- W3208362461 cites W2080829828 @default.
- W3208362461 cites W2082013458 @default.
- W3208362461 cites W2090562908 @default.
- W3208362461 cites W2098014021 @default.
- W3208362461 cites W2100039832 @default.
- W3208362461 cites W2101706701 @default.
- W3208362461 cites W2104101394 @default.
- W3208362461 cites W2106145925 @default.
- W3208362461 cites W2112923665 @default.
- W3208362461 cites W2116250664 @default.
- W3208362461 cites W2126463428 @default.
- W3208362461 cites W2127598826 @default.
- W3208362461 cites W2128677869 @default.
- W3208362461 cites W2133465414 @default.
- W3208362461 cites W2139365787 @default.
- W3208362461 cites W2143036860 @default.
- W3208362461 cites W2145955680 @default.
- W3208362461 cites W2150565980 @default.
- W3208362461 cites W2153178471 @default.
- W3208362461 cites W2158217645 @default.
- W3208362461 cites W2158365762 @default.
- W3208362461 cites W2165067288 @default.
- W3208362461 cites W2165456770 @default.
- W3208362461 cites W2171759387 @default.
- W3208362461 cites W2185075416 @default.
- W3208362461 cites W2228167218 @default.
- W3208362461 cites W2312090439 @default.
- W3208362461 cites W2342931535 @default.
- W3208362461 cites W2347178913 @default.
- W3208362461 cites W2413459687 @default.
- W3208362461 cites W2466598821 @default.
- W3208362461 cites W2480697384 @default.
- W3208362461 cites W2490456769 @default.
- W3208362461 cites W2509070479 @default.
- W3208362461 cites W2519020116 @default.
- W3208362461 cites W2520222164 @default.
- W3208362461 cites W2586223583 @default.
- W3208362461 cites W2588715080 @default.
- W3208362461 cites W2596261790 @default.
- W3208362461 cites W2604821592 @default.
- W3208362461 cites W2607106027 @default.
- W3208362461 cites W2619290461 @default.
- W3208362461 cites W2749860328 @default.
- W3208362461 cites W2758067903 @default.
- W3208362461 cites W2776695687 @default.
- W3208362461 cites W2776798182 @default.
- W3208362461 cites W2912916104 @default.
- W3208362461 cites W2955224282 @default.
- W3208362461 cites W2955245896 @default.
- W3208362461 cites W2973106630 @default.
- W3208362461 cites W2991204446 @default.
- W3208362461 cites W3004338375 @default.
- W3208362461 cites W3017489078 @default.
- W3208362461 cites W3021864086 @default.
- W3208362461 cites W3025659336 @default.
- W3208362461 cites W3026258112 @default.
- W3208362461 cites W3133076643 @default.
- W3208362461 cites W3136963783 @default.
- W3208362461 cites W3193479234 @default.
- W3208362461 cites W4242852378 @default.
- W3208362461 cites W974555012 @default.
- W3208362461 doi "https://doi.org/10.1172/jci.insight.139900" @default.
- W3208362461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34710062" @default.