Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208372565> ?p ?o ?g. }
- W3208372565 endingPage "6568" @default.
- W3208372565 startingPage "6568" @default.
- W3208372565 abstract "The red macroalga Gelidium latifolium is widely distributed in the coastal areas of Indonesia. However, current knowledge on its potential biological activities is still limited. In this study, we investigated the potential bioactive compounds in Gelidium latifolium ethanol extract (GLE), and its cytotoxic effects against the murine B16-F10 melanoma cell line. GLE shows high total phenolic content (107.06 ± 17.42 mg GAE/g) and total flavonoid content (151.77 ± 3.45 mg QE/g), which potentially contribute to its potential antioxidant activity (DPPH = 650.42 ± 2.01 µg/mL; ABTS = 557.01 ± 1.94 µg/mL). ESI-HR-TOF-MS analysis revealed large absorption in the [M-H]- of 327.2339 m/z, corresponding to the monoisotopic molecular mass of brassicolene. The presence of this compound potentially contributes to GLE's cytotoxic activity (IC50 = 84.29 ± 1.93 µg/mL). Furthermore, GLE significantly increased the number of apoptotic cells (66.83 ± 3.06%) compared to controls (18.83 ± 3.76%). Apoptosis was also confirmed by changes in the expression levels of apoptosis-related genes (i.e., p53, Bax, Bak, and Bcl2). Downregulated expression of Bcl2 indicates an intrinsic apoptotic pathway. Current results suggest that components of Gelidium latifolium should be further investigated as possible sources of novel antitumor drugs." @default.
- W3208372565 created "2021-11-08" @default.
- W3208372565 creator A5000324340 @default.
- W3208372565 creator A5002227898 @default.
- W3208372565 creator A5020570070 @default.
- W3208372565 creator A5023438444 @default.
- W3208372565 creator A5030068480 @default.
- W3208372565 creator A5036065065 @default.
- W3208372565 creator A5046867334 @default.
- W3208372565 creator A5064012026 @default.
- W3208372565 creator A5080423726 @default.
- W3208372565 creator A5086386296 @default.
- W3208372565 date "2021-10-30" @default.
- W3208372565 modified "2023-09-26" @default.
- W3208372565 title "The Antiproliferative and Apoptosis-Inducing Effects of the Red Macroalgae Gelidium latifolium Extract against Melanoma Cells" @default.
- W3208372565 cites W1540436551 @default.
- W3208372565 cites W1964284273 @default.
- W3208372565 cites W1983050139 @default.
- W3208372565 cites W1990376421 @default.
- W3208372565 cites W1992597231 @default.
- W3208372565 cites W1998585974 @default.
- W3208372565 cites W2034081022 @default.
- W3208372565 cites W2035292266 @default.
- W3208372565 cites W2036427771 @default.
- W3208372565 cites W2043792432 @default.
- W3208372565 cites W2085207566 @default.
- W3208372565 cites W2087254391 @default.
- W3208372565 cites W2089022942 @default.
- W3208372565 cites W2089123731 @default.
- W3208372565 cites W2091540795 @default.
- W3208372565 cites W2106029128 @default.
- W3208372565 cites W2111573377 @default.
- W3208372565 cites W2121578612 @default.
- W3208372565 cites W2159142921 @default.
- W3208372565 cites W2285953005 @default.
- W3208372565 cites W2460370736 @default.
- W3208372565 cites W2480436110 @default.
- W3208372565 cites W2481325526 @default.
- W3208372565 cites W2489590314 @default.
- W3208372565 cites W2512476894 @default.
- W3208372565 cites W2581887996 @default.
- W3208372565 cites W2588708008 @default.
- W3208372565 cites W2617282941 @default.
- W3208372565 cites W2625405100 @default.
- W3208372565 cites W2766312983 @default.
- W3208372565 cites W2767628069 @default.
- W3208372565 cites W2768800275 @default.
- W3208372565 cites W2769058481 @default.
- W3208372565 cites W2774193952 @default.
- W3208372565 cites W2776048368 @default.
- W3208372565 cites W2783967092 @default.
- W3208372565 cites W2789493304 @default.
- W3208372565 cites W2799501274 @default.
- W3208372565 cites W2799699133 @default.
- W3208372565 cites W2804507361 @default.
- W3208372565 cites W2884925149 @default.
- W3208372565 cites W2887192020 @default.
- W3208372565 cites W2891875808 @default.
- W3208372565 cites W2892069575 @default.
- W3208372565 cites W2892683942 @default.
- W3208372565 cites W2893490240 @default.
- W3208372565 cites W2895926107 @default.
- W3208372565 cites W2898436289 @default.
- W3208372565 cites W2905521792 @default.
- W3208372565 cites W2905963552 @default.
- W3208372565 cites W2940032148 @default.
- W3208372565 cites W2949598921 @default.
- W3208372565 cites W2965490194 @default.
- W3208372565 cites W2966883110 @default.
- W3208372565 cites W2967423279 @default.
- W3208372565 cites W2967843325 @default.
- W3208372565 cites W2975228248 @default.
- W3208372565 cites W2982190600 @default.
- W3208372565 cites W2983700092 @default.
- W3208372565 cites W2995168852 @default.
- W3208372565 cites W3003754048 @default.
- W3208372565 cites W3006237475 @default.
- W3208372565 cites W3018868309 @default.
- W3208372565 cites W3021909056 @default.
- W3208372565 cites W3022612639 @default.
- W3208372565 cites W3034916144 @default.
- W3208372565 cites W3036638167 @default.
- W3208372565 cites W3037287597 @default.
- W3208372565 cites W3045444985 @default.
- W3208372565 cites W3046665064 @default.
- W3208372565 cites W3085479400 @default.
- W3208372565 cites W3088154960 @default.
- W3208372565 cites W3092621209 @default.
- W3208372565 cites W3093261693 @default.
- W3208372565 cites W3128995791 @default.
- W3208372565 cites W3129919167 @default.
- W3208372565 cites W3158053411 @default.
- W3208372565 cites W3178707038 @default.
- W3208372565 cites W4244771168 @default.
- W3208372565 doi "https://doi.org/10.3390/molecules26216568" @default.
- W3208372565 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8587204" @default.
- W3208372565 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34770978" @default.
- W3208372565 hasPublicationYear "2021" @default.