Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208382660> ?p ?o ?g. }
- W3208382660 endingPage "5756" @default.
- W3208382660 startingPage "5739" @default.
- W3208382660 abstract "Due to the risk of gastrointestinal damage and various tissue toxicity associated with non-steroidal anti-inflammatory drugs (NSAIDs) use, investigating new anti-inflammatory agents with efficacy comparable to that of NSAIDs but reduced toxicity is still a major challenge and a clinical need. Based on our previous study, new 1,3,4-oxadiazole derivatives of pyrrolo[3,4-d]pyridazinone, especially 6-butyl-3,5,7-trimethyl-1-[[4-[[4-(4-nitrophenyl)piperazin-1-yl]methyl]-5-thioxo-1,3,4-oxadiazol-2-yl]methoxy]pyrrolo[3,4-d]pyridazin-4-one and 6-butyl-1-[[4-[[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]methyl]-2-thioxo-1,3,4-oxadiazol-5-yl]methoxy]-3,5,7-trimethyl-pyrrolo[3,4-d]pyridazin-4-one (hereafter referred to as the compounds 10b and 13b, respectively) seem to be promising anti-inflammatory agents. This study aimed to elucidate the effects of these two new derivatives on the course of experimental rat inflammation, liver and kidney function, and gastric mucosa.The anti-inflammatory effect of compounds 10b and 13b was evaluated using the carrageenan-induced paw edema test in rats. The increase in paw volume (paw edema), prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α) and myeloperoxidase (MPO) levels, histological alterations, and inflammatory cell infiltration in paw tissue were determined. Serum alanine transaminase (ALT) and aspartate transaminase (AST) activities, serum urea and creatinine levels, as well as changes in gastric mucosa, were measured as indicators of hepatic, renal, and gastric toxicity.Pretreatment with both novel derivatives at 10 mg/kg and 20 mg/kg doses reduced paw edema, counteracted the increased PGE2 and TNF-α levels, reduced the influx of inflammatory cells, and decreased histopathological alterations in paw tissue. Compound 13b at a dose of 20 mg/kg was more effective than indomethacin in reversing the increased TNF-α levels and reducing the influx of inflammatory cells. Only compound 13b at all studied doses (5, 10, or 20 mg/kg) counteracted the increased MPO level in paw tissue. Both compounds neither caused alterations in ALT, AST, urea, creatinine parameters nor gastric mucosal lesions.New compounds exert an anti-inflammatory effect, presumably via inhibiting inflammatory mediators release and inflammatory cell infiltration. Moreover, both possess a more favorable benefit-risk profile than indomethacin, especially compound 13b." @default.
- W3208382660 created "2021-11-08" @default.
- W3208382660 creator A5036621514 @default.
- W3208382660 creator A5044262869 @default.
- W3208382660 creator A5048026929 @default.
- W3208382660 creator A5058244882 @default.
- W3208382660 creator A5070725053 @default.
- W3208382660 creator A5073253235 @default.
- W3208382660 creator A5073372613 @default.
- W3208382660 creator A5073877230 @default.
- W3208382660 creator A5076467955 @default.
- W3208382660 date "2021-11-01" @default.
- W3208382660 modified "2023-10-12" @default.
- W3208382660 title "Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]Pyridazinone Exert Anti-Inflammatory Activity without Acute Gastrotoxicity in the Carrageenan-Induced Rat Paw Edema Test" @default.
- W3208382660 cites W1714506000 @default.
- W3208382660 cites W1945678433 @default.
- W3208382660 cites W1955062377 @default.
- W3208382660 cites W1970652854 @default.
- W3208382660 cites W1979020782 @default.
- W3208382660 cites W1981819970 @default.
- W3208382660 cites W1988564036 @default.
- W3208382660 cites W2003212869 @default.
- W3208382660 cites W2012104203 @default.
- W3208382660 cites W2017975422 @default.
- W3208382660 cites W2021729573 @default.
- W3208382660 cites W2021988356 @default.
- W3208382660 cites W2023443238 @default.
- W3208382660 cites W2023788245 @default.
- W3208382660 cites W2031084334 @default.
- W3208382660 cites W2034741252 @default.
- W3208382660 cites W2036501662 @default.
- W3208382660 cites W2038265997 @default.
- W3208382660 cites W2039107480 @default.
- W3208382660 cites W2040252933 @default.
- W3208382660 cites W2047105807 @default.
- W3208382660 cites W2047718984 @default.
- W3208382660 cites W2059885690 @default.
- W3208382660 cites W2060198845 @default.
- W3208382660 cites W2075715972 @default.
- W3208382660 cites W2086173635 @default.
- W3208382660 cites W2134294696 @default.
- W3208382660 cites W2134522318 @default.
- W3208382660 cites W2140044845 @default.
- W3208382660 cites W2148727766 @default.
- W3208382660 cites W2173181922 @default.
- W3208382660 cites W2259983755 @default.
- W3208382660 cites W2322880484 @default.
- W3208382660 cites W2510043997 @default.
- W3208382660 cites W2511374397 @default.
- W3208382660 cites W2563381061 @default.
- W3208382660 cites W2744589322 @default.
- W3208382660 cites W2772755903 @default.
- W3208382660 cites W2783428982 @default.
- W3208382660 cites W2791016534 @default.
- W3208382660 cites W2806149135 @default.
- W3208382660 cites W2886399850 @default.
- W3208382660 cites W2894960999 @default.
- W3208382660 cites W2910915966 @default.
- W3208382660 cites W2923513751 @default.
- W3208382660 cites W2927275355 @default.
- W3208382660 cites W2945316433 @default.
- W3208382660 cites W2949581466 @default.
- W3208382660 cites W3016090730 @default.
- W3208382660 cites W3016446975 @default.
- W3208382660 cites W3016455563 @default.
- W3208382660 cites W3021324597 @default.
- W3208382660 cites W3023374249 @default.
- W3208382660 cites W3031944648 @default.
- W3208382660 cites W3036426532 @default.
- W3208382660 cites W3039772549 @default.
- W3208382660 cites W3041720930 @default.
- W3208382660 cites W3094206545 @default.
- W3208382660 cites W3112177962 @default.
- W3208382660 cites W3135577365 @default.
- W3208382660 cites W382137780 @default.
- W3208382660 doi "https://doi.org/10.2147/jir.s330614" @default.
- W3208382660 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8572108" @default.
- W3208382660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34754217" @default.
- W3208382660 hasPublicationYear "2021" @default.
- W3208382660 type Work @default.
- W3208382660 sameAs 3208382660 @default.
- W3208382660 citedByCount "10" @default.
- W3208382660 countsByYear W32083826602022 @default.
- W3208382660 countsByYear W32083826602023 @default.
- W3208382660 crossrefType "journal-article" @default.
- W3208382660 hasAuthorship W3208382660A5036621514 @default.
- W3208382660 hasAuthorship W3208382660A5044262869 @default.
- W3208382660 hasAuthorship W3208382660A5048026929 @default.
- W3208382660 hasAuthorship W3208382660A5058244882 @default.
- W3208382660 hasAuthorship W3208382660A5070725053 @default.
- W3208382660 hasAuthorship W3208382660A5073253235 @default.
- W3208382660 hasAuthorship W3208382660A5073372613 @default.
- W3208382660 hasAuthorship W3208382660A5073877230 @default.
- W3208382660 hasAuthorship W3208382660A5076467955 @default.
- W3208382660 hasBestOaLocation W32083826601 @default.
- W3208382660 hasConcept C126322002 @default.
- W3208382660 hasConcept C160160445 @default.
- W3208382660 hasConcept C178790620 @default.