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- W3208392810 abstract "A decrease in glutathione (GSH) levels is considered one of the earliest biochemical changes in Parkinson's disease (PD).The authors explored the potential role of plasma GSH as a risk/susceptibility biomarker for prodromal PD (pPD) by examining its longitudinal associations with pPD probability trajectories.A total of 405 community-dwelling participants (median age [interquartile range] = 73.2 [7.41] years) without clinical features of parkinsonism were followed for a mean (standard deviation) of 3.0 (0.9) years.A 1 μmol/L increase in plasma GSH was associated with 0.4% (95% confidence interval [CI], 0.1%-0.7%; P = 0.017) less increase in pPD probability for 1 year of follow-up. Compared with participants in the lowest GSH tertile, participants in the highest GSH tertile had a 12.9% (95% CI, 22.4%-2.2%; P = 0.020) slower rate of increase of pPD probability for 1 year of follow-up.Plasma GSH was associated with pPD probability trajectories; therefore, it might assist in the identification of individuals who are likely to reach the threshold for pPD diagnosis more rapidly. © 2021 International Parkinson and Movement Disorder Society." @default.
- W3208392810 created "2021-11-08" @default.
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- W3208392810 date "2021-10-25" @default.
- W3208392810 modified "2023-10-15" @default.
- W3208392810 title "Plasma Glutathione and Prodromal Parkinson's Disease Probability" @default.
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- W3208392810 doi "https://doi.org/10.1002/mds.28826" @default.
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