FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208398889> ?p ?o ?g. }

• W3208398889 abstract "Many pathogenic bacteria are encased in a layer of capsular polysaccharide (CPS). This layer is important for virulence by masking surface antigens, preventing opsonophagocytosis, and avoiding mucus entrapment. The bacterial tyrosine kinase (BY-kinase) regulates capsule synthesis and helps bacterial pathogens to survive different host niches. BY-kinases autophosphorylate at the C-terminal tyrosine residues upon external stimuli, but the role of phosphorylation is still unclear. Here, we report that the BY-kinase CpsCD is required for growth in Streptococcus pneumoniae Cells lacking a functional cpsC or cpsD accumulated low molecular weight CPS and lysed because of the lethal sequestration of the lipid carrier undecaprenyl phosphate, resulting in inhibition of peptidoglycan (PG) synthesis. CpsC interacts with CpsD and the polymerase CpsH. CpsD phosphorylation reduces the length of CPS polymers presumably by controlling the activity of CpsC. Finally, pulse-chase experiments reveal the spatiotemporal coordination between CPS and PG synthesis. This coordination is dependent on CpsC and CpsD. Together, our study provides evidence that BY-kinases regulate capsule polymer length by fine-tuning CpsC activity through autophosphorylation." @default.
• W3208398889 created "2021-11-08" @default.
• W3208398889 creator A5003058623 @default.
• W3208398889 creator A5009749498 @default.
• W3208398889 creator A5027927258 @default.
• W3208398889 creator A5051478207 @default.
• W3208398889 creator A5054276215 @default.
• W3208398889 creator A5060030884 @default.
• W3208398889 creator A5071075145 @default.
• W3208398889 creator A5078735601 @default.
• W3208398889 creator A5089564618 @default.
• W3208398889 date "2021-11-03" @default.
• W3208398889 modified "2023-10-02" @default.
• W3208398889 title "The bacterial tyrosine kinase system CpsBCD governs the length of capsule polymers" @default.
• W3208398889 cites W1570017351 @default.
• W3208398889 cites W1611779324 @default.
• W3208398889 cites W1649213228 @default.
• W3208398889 cites W1725441227 @default.
• W3208398889 cites W1867952113 @default.
• W3208398889 cites W1905036359 @default.
• W3208398889 cites W1934738351 @default.
• W3208398889 cites W1954112402 @default.
• W3208398889 cites W1981039934 @default.
• W3208398889 cites W2002020281 @default.
• W3208398889 cites W2012925826 @default.
• W3208398889 cites W2017331448 @default.
• W3208398889 cites W2030924818 @default.
• W3208398889 cites W2037409969 @default.
• W3208398889 cites W2038992687 @default.
• W3208398889 cites W2041592960 @default.
• W3208398889 cites W2044906203 @default.
• W3208398889 cites W2048570423 @default.
• W3208398889 cites W2053602903 @default.
• W3208398889 cites W2055177969 @default.
• W3208398889 cites W2062930259 @default.
• W3208398889 cites W2077128644 @default.
• W3208398889 cites W2080082312 @default.
• W3208398889 cites W2083848382 @default.
• W3208398889 cites W2086966899 @default.
• W3208398889 cites W2093717213 @default.
• W3208398889 cites W2099535366 @default.
• W3208398889 cites W2100427997 @default.
• W3208398889 cites W2112260735 @default.
• W3208398889 cites W2113099409 @default.
• W3208398889 cites W2119458127 @default.
• W3208398889 cites W2120057950 @default.
• W3208398889 cites W2121102152 @default.
• W3208398889 cites W2121380313 @default.
• W3208398889 cites W2128295130 @default.
• W3208398889 cites W2137904284 @default.
• W3208398889 cites W2143584491 @default.
• W3208398889 cites W2156659808 @default.
• W3208398889 cites W2160821408 @default.
• W3208398889 cites W2171857175 @default.
• W3208398889 cites W2233212863 @default.
• W3208398889 cites W2292669177 @default.
• W3208398889 cites W2300552860 @default.
• W3208398889 cites W2467964007 @default.
• W3208398889 cites W2488863909 @default.
• W3208398889 cites W2517142221 @default.
• W3208398889 cites W2517176893 @default.
• W3208398889 cites W2560205506 @default.
• W3208398889 cites W2563859344 @default.
• W3208398889 cites W2564679034 @default.
• W3208398889 cites W2587265764 @default.
• W3208398889 cites W2612977393 @default.
• W3208398889 cites W2625328556 @default.
• W3208398889 cites W2729612146 @default.
• W3208398889 cites W2885802470 @default.
• W3208398889 cites W2889562406 @default.
• W3208398889 cites W2911983544 @default.
• W3208398889 cites W2922524486 @default.
• W3208398889 cites W2925443009 @default.
• W3208398889 cites W2940289922 @default.
• W3208398889 cites W2951041301 @default.
• W3208398889 cites W2951525333 @default.
• W3208398889 cites W3012051463 @default.
• W3208398889 cites W3027219640 @default.
• W3208398889 cites W3124082014 @default.
• W3208398889 doi "https://doi.org/10.1073/pnas.2103377118" @default.
• W3208398889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8609450" @default.
• W3208398889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34732571" @default.
• W3208398889 hasPublicationYear "2021" @default.
• W3208398889 type Work @default.
• W3208398889 sameAs 3208398889 @default.
• W3208398889 citedByCount "6" @default.
• W3208398889 countsByYear W32083988892022 @default.
• W3208398889 countsByYear W32083988892023 @default.
• W3208398889 crossrefType "journal-article" @default.
• W3208398889 hasAuthorship W3208398889A5003058623 @default.
• W3208398889 hasAuthorship W3208398889A5009749498 @default.
• W3208398889 hasAuthorship W3208398889A5027927258 @default.
• W3208398889 hasAuthorship W3208398889A5051478207 @default.
• W3208398889 hasAuthorship W3208398889A5054276215 @default.
• W3208398889 hasAuthorship W3208398889A5060030884 @default.
• W3208398889 hasAuthorship W3208398889A5071075145 @default.
• W3208398889 hasAuthorship W3208398889A5078735601 @default.
• W3208398889 hasAuthorship W3208398889A5089564618 @default.
• W3208398889 hasBestOaLocation W32083988892 @default.
• W3208398889 hasConcept C104317684 @default.

• next