Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208400701> ?p ?o ?g. }
- W3208400701 endingPage "109899" @default.
- W3208400701 startingPage "109899" @default.
- W3208400701 abstract "Although commonly associated with autophagosomes, LC3 can also be recruited to membranes by covalent lipidation in a variety of non-canonical contexts. These include responses to ionophores such as the M2 proton channel of influenza A virus. We report a subtractive CRISPR screen that identifies factors required for non-canonical LC3 lipidation. As well as the enzyme complexes directly responsible for LC3 lipidation in all contexts, we show the RALGAP complex is important for M2-induced, but not ionophore drug-induced, LC3 lipidation. In contrast, ATG4D is responsible for LC3 recycling in M2-induced and basal LC3 lipidation. Identification of a vacuolar ATPase subunit in the screen suggests a common mechanism for non-canonical LC3 recruitment. Influenza-induced and ionophore drug-induced LC3 lipidation lead to association of the vacuolar ATPase and ATG16L1 and can be antagonized by Salmonella SopF. LC3 recruitment to erroneously neutral compartments may therefore represent a response to damage caused by diverse invasive pathogens." @default.
- W3208400701 created "2021-11-08" @default.
- W3208400701 creator A5019458968 @default.
- W3208400701 creator A5020085209 @default.
- W3208400701 creator A5030207846 @default.
- W3208400701 creator A5030523023 @default.
- W3208400701 creator A5032622365 @default.
- W3208400701 creator A5033694495 @default.
- W3208400701 creator A5036690566 @default.
- W3208400701 creator A5051018119 @default.
- W3208400701 creator A5071095963 @default.
- W3208400701 creator A5004782235 @default.
- W3208400701 date "2021-10-01" @default.
- W3208400701 modified "2023-10-12" @default.
- W3208400701 title "Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation" @default.
- W3208400701 cites W1526993239 @default.
- W3208400701 cites W1555054913 @default.
- W3208400701 cites W1943068820 @default.
- W3208400701 cites W1970615437 @default.
- W3208400701 cites W1973260880 @default.
- W3208400701 cites W1977077130 @default.
- W3208400701 cites W1977709885 @default.
- W3208400701 cites W1981453024 @default.
- W3208400701 cites W1985124617 @default.
- W3208400701 cites W1990437594 @default.
- W3208400701 cites W2014321318 @default.
- W3208400701 cites W2014683141 @default.
- W3208400701 cites W2018418660 @default.
- W3208400701 cites W2026312959 @default.
- W3208400701 cites W2027558005 @default.
- W3208400701 cites W2031211461 @default.
- W3208400701 cites W2047802226 @default.
- W3208400701 cites W2051154138 @default.
- W3208400701 cites W2057813271 @default.
- W3208400701 cites W2058496516 @default.
- W3208400701 cites W2060008923 @default.
- W3208400701 cites W2065031087 @default.
- W3208400701 cites W2068854805 @default.
- W3208400701 cites W2088140877 @default.
- W3208400701 cites W2109110743 @default.
- W3208400701 cites W2122514972 @default.
- W3208400701 cites W2125572458 @default.
- W3208400701 cites W2154249083 @default.
- W3208400701 cites W2154311364 @default.
- W3208400701 cites W2167279371 @default.
- W3208400701 cites W2171520517 @default.
- W3208400701 cites W2285592953 @default.
- W3208400701 cites W2580035316 @default.
- W3208400701 cites W2588453582 @default.
- W3208400701 cites W2621524487 @default.
- W3208400701 cites W2782659115 @default.
- W3208400701 cites W2800318609 @default.
- W3208400701 cites W2914069680 @default.
- W3208400701 cites W2961013416 @default.
- W3208400701 cites W3000124759 @default.
- W3208400701 cites W3105265817 @default.
- W3208400701 cites W3157582528 @default.
- W3208400701 doi "https://doi.org/10.1016/j.celrep.2021.109899" @default.
- W3208400701 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8567314" @default.
- W3208400701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34706226" @default.
- W3208400701 hasPublicationYear "2021" @default.
- W3208400701 type Work @default.
- W3208400701 sameAs 3208400701 @default.
- W3208400701 citedByCount "24" @default.
- W3208400701 countsByYear W32084007012022 @default.
- W3208400701 countsByYear W32084007012023 @default.
- W3208400701 crossrefType "journal-article" @default.
- W3208400701 hasAuthorship W3208400701A5004782235 @default.
- W3208400701 hasAuthorship W3208400701A5019458968 @default.
- W3208400701 hasAuthorship W3208400701A5020085209 @default.
- W3208400701 hasAuthorship W3208400701A5030207846 @default.
- W3208400701 hasAuthorship W3208400701A5030523023 @default.
- W3208400701 hasAuthorship W3208400701A5032622365 @default.
- W3208400701 hasAuthorship W3208400701A5033694495 @default.
- W3208400701 hasAuthorship W3208400701A5036690566 @default.
- W3208400701 hasAuthorship W3208400701A5051018119 @default.
- W3208400701 hasAuthorship W3208400701A5071095963 @default.
- W3208400701 hasBestOaLocation W32084007011 @default.
- W3208400701 hasConcept C104292427 @default.
- W3208400701 hasConcept C104317684 @default.
- W3208400701 hasConcept C131934819 @default.
- W3208400701 hasConcept C185592680 @default.
- W3208400701 hasConcept C190283241 @default.
- W3208400701 hasConcept C193469717 @default.
- W3208400701 hasConcept C203522944 @default.
- W3208400701 hasConcept C2776104367 @default.
- W3208400701 hasConcept C55493867 @default.
- W3208400701 hasConcept C86803240 @default.
- W3208400701 hasConcept C95444343 @default.
- W3208400701 hasConcept C98108389 @default.
- W3208400701 hasConceptScore W3208400701C104292427 @default.
- W3208400701 hasConceptScore W3208400701C104317684 @default.
- W3208400701 hasConceptScore W3208400701C131934819 @default.
- W3208400701 hasConceptScore W3208400701C185592680 @default.
- W3208400701 hasConceptScore W3208400701C190283241 @default.
- W3208400701 hasConceptScore W3208400701C193469717 @default.
- W3208400701 hasConceptScore W3208400701C203522944 @default.
- W3208400701 hasConceptScore W3208400701C2776104367 @default.