FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208408839> ?p ?o ?g. }

• W3208408839 endingPage "74" @default.
• W3208408839 startingPage "60" @default.
• W3208408839 abstract "To develop novel antimicrobial agents, and based on the biologically active heterocyclic quinoline and thiazole substituted, a series of novel α-aminophosphonates (9a-h) and (10i-l) derivatives that incorporated quinoline or quinolone, and coumarylthiazole or 5-phenylthiazol-2-amine moieties were designed and synthesized via Kabachnik-Fields reaction in the presence of ionic liquid under ultrasound irradiation. All the new compounds were obtained in good yield with a simple workup and were confirmed using various spectroscopic methods. The in vitro antimicrobial activity of all synthesized compounds were screened in terms of MIC values against the selected strains of Gram-negative and Gram-positive bacteria and two fungal strains using the broth micro-dilution method. The results showed that most of the tested compounds showed moderate inhibitory activities against both Gram-positive and -negative bacteria compared with reference drugs. The following compounds 9e, 9g, 9h, 9i and 9f, 9g, 9h, 10k, 10l are the most active against Gram-positive and Gram-negative bacteria strains, respectively, with MIC values ranging between 0.25 and 128 μg/mL. The synthesized compounds 9b, 9c, 9f, 9g, 9h, 10k, and 10l exhibited excellent antifungal inhibition with MIC values ranging between 0.25 and 32 μg/mL. Structure-activity relationship revealed that the presence of coumarylthiazole moiety and hydroxyl in the quinoline group increased the inhibitory activity against microbial strains pathogens. These results confirm that the synthesized compounds can be potential antimicrobial drugs candidate." @default.
• W3208408839 created "2021-11-08" @default.
• W3208408839 creator A5075408203 @default.
• W3208408839 creator A5077221897 @default.
• W3208408839 creator A5081559647 @default.
• W3208408839 creator A5087489877 @default.
• W3208408839 date "2021-11-02" @default.
• W3208408839 modified "2023-10-01" @default.
• W3208408839 title "Synthesis and potential antimicrobial activity of novel α-aminophosphonates derivatives bearing substituted quinoline or quinolone and thiazole moieties" @default.
• W3208408839 cites W1969050729 @default.
• W3208408839 cites W1972226982 @default.
• W3208408839 cites W1979583370 @default.
• W3208408839 cites W2003917526 @default.
• W3208408839 cites W2060892523 @default.
• W3208408839 cites W2081183202 @default.
• W3208408839 cites W2115743517 @default.
• W3208408839 cites W2199499186 @default.
• W3208408839 cites W2291072068 @default.
• W3208408839 cites W2302054193 @default.
• W3208408839 cites W2325192560 @default.
• W3208408839 cites W2511708892 @default.
• W3208408839 cites W2604642172 @default.
• W3208408839 cites W2889016323 @default.
• W3208408839 cites W2905361387 @default.
• W3208408839 cites W2915875353 @default.
• W3208408839 cites W2937952980 @default.
• W3208408839 cites W2949291830 @default.
• W3208408839 cites W2949403750 @default.
• W3208408839 cites W2950017317 @default.
• W3208408839 cites W2950811396 @default.
• W3208408839 cites W2951060963 @default.
• W3208408839 cites W2951888945 @default.
• W3208408839 cites W2952261537 @default.
• W3208408839 cites W2963355712 @default.
• W3208408839 cites W2987991219 @default.
• W3208408839 cites W2998519172 @default.
• W3208408839 cites W2999064266 @default.
• W3208408839 cites W3001712084 @default.
• W3208408839 cites W3003632635 @default.
• W3208408839 cites W3004600646 @default.
• W3208408839 cites W3006408725 @default.
• W3208408839 cites W3008703043 @default.
• W3208408839 cites W3010277308 @default.
• W3208408839 cites W3010930696 @default.
• W3208408839 cites W3013899502 @default.
• W3208408839 cites W3031835427 @default.
• W3208408839 cites W3033918520 @default.
• W3208408839 cites W3038888092 @default.
• W3208408839 cites W3080321652 @default.
• W3208408839 cites W3081100975 @default.
• W3208408839 cites W3093238546 @default.
• W3208408839 cites W3098849776 @default.
• W3208408839 cites W3112970769 @default.
• W3208408839 cites W3115471358 @default.
• W3208408839 cites W3122785142 @default.
• W3208408839 cites W3129381498 @default.
• W3208408839 cites W3133778573 @default.
• W3208408839 cites W3169986805 @default.
• W3208408839 cites W4247651210 @default.
• W3208408839 doi "https://doi.org/10.1007/s00044-021-02815-5" @default.
• W3208408839 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8560884" @default.
• W3208408839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34744408" @default.
• W3208408839 hasPublicationYear "2021" @default.
• W3208408839 type Work @default.
• W3208408839 sameAs 3208408839 @default.
• W3208408839 citedByCount "13" @default.
• W3208408839 countsByYear W32084088392022 @default.
• W3208408839 countsByYear W32084088392023 @default.
• W3208408839 crossrefType "journal-article" @default.
• W3208408839 hasAuthorship W3208408839A5075408203 @default.
• W3208408839 hasAuthorship W3208408839A5077221897 @default.
• W3208408839 hasAuthorship W3208408839A5081559647 @default.
• W3208408839 hasAuthorship W3208408839A5087489877 @default.
• W3208408839 hasBestOaLocation W32084088391 @default.
• W3208408839 hasConcept C176947019 @default.
• W3208408839 hasConcept C178790620 @default.
• W3208408839 hasConcept C185592680 @default.
• W3208408839 hasConcept C21951064 @default.
• W3208408839 hasConcept C2776309666 @default.
• W3208408839 hasConcept C2776568683 @default.
• W3208408839 hasConcept C2778464347 @default.
• W3208408839 hasConcept C2779518903 @default.
• W3208408839 hasConcept C2779922871 @default.
• W3208408839 hasConcept C4937899 @default.
• W3208408839 hasConcept C501593827 @default.
• W3208408839 hasConcept C523546767 @default.
• W3208408839 hasConcept C54355233 @default.
• W3208408839 hasConcept C55493867 @default.
• W3208408839 hasConcept C71240020 @default.
• W3208408839 hasConcept C86803240 @default.
• W3208408839 hasConceptScore W3208408839C176947019 @default.
• W3208408839 hasConceptScore W3208408839C178790620 @default.
• W3208408839 hasConceptScore W3208408839C185592680 @default.
• W3208408839 hasConceptScore W3208408839C21951064 @default.
• W3208408839 hasConceptScore W3208408839C2776309666 @default.
• W3208408839 hasConceptScore W3208408839C2776568683 @default.
• W3208408839 hasConceptScore W3208408839C2778464347 @default.
• W3208408839 hasConceptScore W3208408839C2779518903 @default.

• next