Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208477388> ?p ?o ?g. }
- W3208477388 endingPage "605" @default.
- W3208477388 startingPage "596" @default.
- W3208477388 abstract "In the current study, biogenic silver nanoparticles (U-AgNPs) were synthesized using marine green macro-algal Ulva lactuca extract, and evaluated mechanism behind its anticancer activity against the Human colon cancer (HCT-116). The biogenic U-AgNPs were characterized using various physiochemical techniques. The TEM micrographs confirmed the spherical morphology of synthesized U-AgNPs, with a mean size of 8–14 nm. EDX spectrum as well as ICP-OES confirmed that AgNPs was nearly 90% purity for silver. FTIR Spectra analysis of U-AgNPs confirmed U. lactuca extract bioactive molecules presence over U-AgNPs surface as a stabilizing agent, thereby improving biocompatibility. The cytotoxicity study revealed the dose dependent cell death in colon cancer cells with no loss of viability in normal human colon epithelial cells. Furthermore, the fluorescence micrographs of nucleus staining assay revealed the DNA fragmentation and nucleus condensation of cancer cells treated with U-AgNPs, indicating an apoptosis-mediated cell death. The western bolt and RT-PCR analysis of U-AgNPs treated cancer cells showed the rise in proapoptotic markers (P53, Bax, and P21) and decline in anti-apoptotic markers (Bcl-2), thus confirming the p53-dependent apoptosis mediated cell death in HCT-116. Overall, our study concluded that novel biogenic U-AgNPs nanoparticles, synthesized using marine green macro-algal U. lactuca extract showed efficient anticancer activity against HCT-116 cell line and hence could work as potential therapeutic agent for targeted anti-cancer therapy." @default.
- W3208477388 created "2021-11-08" @default.
- W3208477388 creator A5002306556 @default.
- W3208477388 creator A5007555239 @default.
- W3208477388 creator A5030131412 @default.
- W3208477388 creator A5057574600 @default.
- W3208477388 creator A5082430237 @default.
- W3208477388 date "2021-10-21" @default.
- W3208477388 modified "2023-10-12" @default.
- W3208477388 title "Systemic Evaluation of Mechanism of Cytotoxicity in Human Colon Cancer HCT-116 Cells of Silver Nanoparticles Synthesized Using Marine Algae Ulva lactuca Extract" @default.
- W3208477388 cites W1928446752 @default.
- W3208477388 cites W2018489233 @default.
- W3208477388 cites W2039382778 @default.
- W3208477388 cites W2073131323 @default.
- W3208477388 cites W2141237239 @default.
- W3208477388 cites W255442691 @default.
- W3208477388 cites W2591365056 @default.
- W3208477388 cites W2613280601 @default.
- W3208477388 cites W2624683199 @default.
- W3208477388 cites W2802927280 @default.
- W3208477388 cites W2804942630 @default.
- W3208477388 cites W2807092944 @default.
- W3208477388 cites W2886080030 @default.
- W3208477388 cites W2895096270 @default.
- W3208477388 cites W2906942922 @default.
- W3208477388 cites W2917934787 @default.
- W3208477388 cites W2944087998 @default.
- W3208477388 cites W2947997961 @default.
- W3208477388 cites W2954727344 @default.
- W3208477388 cites W2954858470 @default.
- W3208477388 cites W2983909799 @default.
- W3208477388 cites W3008589136 @default.
- W3208477388 cites W3014883499 @default.
- W3208477388 cites W3017069776 @default.
- W3208477388 cites W3042721953 @default.
- W3208477388 cites W3047431598 @default.
- W3208477388 cites W3110661135 @default.
- W3208477388 cites W3116334512 @default.
- W3208477388 cites W3127296963 @default.
- W3208477388 cites W3134362464 @default.
- W3208477388 cites W3145960958 @default.
- W3208477388 cites W3169050004 @default.
- W3208477388 cites W3195970864 @default.
- W3208477388 doi "https://doi.org/10.1007/s10904-021-02133-8" @default.
- W3208477388 hasPublicationYear "2021" @default.
- W3208477388 type Work @default.
- W3208477388 sameAs 3208477388 @default.
- W3208477388 citedByCount "11" @default.
- W3208477388 countsByYear W32084773882021 @default.
- W3208477388 countsByYear W32084773882022 @default.
- W3208477388 countsByYear W32084773882023 @default.
- W3208477388 crossrefType "journal-article" @default.
- W3208477388 hasAuthorship W3208477388A5002306556 @default.
- W3208477388 hasAuthorship W3208477388A5007555239 @default.
- W3208477388 hasAuthorship W3208477388A5030131412 @default.
- W3208477388 hasAuthorship W3208477388A5057574600 @default.
- W3208477388 hasAuthorship W3208477388A5082430237 @default.
- W3208477388 hasBestOaLocation W32084773882 @default.
- W3208477388 hasConcept C109316439 @default.
- W3208477388 hasConcept C121608353 @default.
- W3208477388 hasConcept C153911025 @default.
- W3208477388 hasConcept C155672457 @default.
- W3208477388 hasConcept C171250308 @default.
- W3208477388 hasConcept C178790620 @default.
- W3208477388 hasConcept C185592680 @default.
- W3208477388 hasConcept C190283241 @default.
- W3208477388 hasConcept C192562407 @default.
- W3208477388 hasConcept C202751555 @default.
- W3208477388 hasConcept C2777230088 @default.
- W3208477388 hasConcept C2778343920 @default.
- W3208477388 hasConcept C2779678208 @default.
- W3208477388 hasConcept C31499863 @default.
- W3208477388 hasConcept C31573885 @default.
- W3208477388 hasConcept C43759708 @default.
- W3208477388 hasConcept C54355233 @default.
- W3208477388 hasConcept C55493867 @default.
- W3208477388 hasConcept C59822182 @default.
- W3208477388 hasConcept C86803240 @default.
- W3208477388 hasConcept C96232424 @default.
- W3208477388 hasConceptScore W3208477388C109316439 @default.
- W3208477388 hasConceptScore W3208477388C121608353 @default.
- W3208477388 hasConceptScore W3208477388C153911025 @default.
- W3208477388 hasConceptScore W3208477388C155672457 @default.
- W3208477388 hasConceptScore W3208477388C171250308 @default.
- W3208477388 hasConceptScore W3208477388C178790620 @default.
- W3208477388 hasConceptScore W3208477388C185592680 @default.
- W3208477388 hasConceptScore W3208477388C190283241 @default.
- W3208477388 hasConceptScore W3208477388C192562407 @default.
- W3208477388 hasConceptScore W3208477388C202751555 @default.
- W3208477388 hasConceptScore W3208477388C2777230088 @default.
- W3208477388 hasConceptScore W3208477388C2778343920 @default.
- W3208477388 hasConceptScore W3208477388C2779678208 @default.
- W3208477388 hasConceptScore W3208477388C31499863 @default.
- W3208477388 hasConceptScore W3208477388C31573885 @default.
- W3208477388 hasConceptScore W3208477388C43759708 @default.
- W3208477388 hasConceptScore W3208477388C54355233 @default.
- W3208477388 hasConceptScore W3208477388C55493867 @default.
- W3208477388 hasConceptScore W3208477388C59822182 @default.