FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208477687> ?p ?o ?g. }

• W3208477687 endingPage "213" @default.
• W3208477687 startingPage "201" @default.
• W3208477687 abstract "SIRT3 is an NAD+-dependent protein deacetylase localized in mitochondria. Several studies reported localization of SIRT3 in the cytoplasm or nucleus, but data of these studies were not consistent. We detected expression of mitochondrial (SIRT3mt) and cytoplasmic (SIRT3ct) Sirt3 mRNAs in the mouse brain, and we also found SIRT3 immunostaining of mitochondria and cytoplasm in the brain and cultured neural cells. However, expression levels of SIRT3ct in COS cells transfected with SIRT3ct cDNA were much lower than those of SIRT3mt. We found that SIRT3ct but not SIRT3mt was promptly degraded by ubiquitin-dependent degradation, in which SIRT3ct degradation was mediated mainly by ubiquitination of NH2-terminal methionine and partly by that of lysine residues of SIRT3ct. SIRT3ct expression level was significantly enhanced by the treatment of cells with staurosporine or H2O2. H2O2 treatment promoted nuclear translocation of SIRT3ct and induced histone H3 deacetylation and superoxide dismutase 2 expression. Overexpression of SIRT3ct decreased cell death caused by H2O2 at levels similar to those achieved by overexpression of SIRT3mt. Knockdown of Sirt3 mRNA increased cell death caused by amyloid-β (Aβ), and overexpression of SIRT3ct suppressed the toxic function of Aβ in PC12 cells. These results indicate that SIRT3ct promotes cell survival under physiological and pathological conditions." @default.
• W3208477687 created "2021-11-08" @default.
• W3208477687 creator A5006011729 @default.
• W3208477687 creator A5007717696 @default.
• W3208477687 creator A5015624012 @default.
• W3208477687 creator A5044265229 @default.
• W3208477687 creator A5046107109 @default.
• W3208477687 creator A5063402092 @default.
• W3208477687 creator A5065602028 @default.
• W3208477687 creator A5084931452 @default.
• W3208477687 creator A5086651873 @default.
• W3208477687 creator A5088123955 @default.
• W3208477687 date "2021-10-29" @default.
• W3208477687 modified "2023-10-17" @default.
• W3208477687 title "Ubiquitin-dependent rapid degradation conceals a cell-protective function of cytoplasmic SIRT3 against oxidative stress" @default.
• W3208477687 cites W1553938284 @default.
• W3208477687 cites W1964059126 @default.
• W3208477687 cites W1977014064 @default.
• W3208477687 cites W1979745754 @default.
• W3208477687 cites W1981281388 @default.
• W3208477687 cites W1984942409 @default.
• W3208477687 cites W1989164058 @default.
• W3208477687 cites W2006376420 @default.
• W3208477687 cites W2007944863 @default.
• W3208477687 cites W2010312807 @default.
• W3208477687 cites W2019672253 @default.
• W3208477687 cites W2031126383 @default.
• W3208477687 cites W2039374791 @default.
• W3208477687 cites W2042710774 @default.
• W3208477687 cites W2053761133 @default.
• W3208477687 cites W2073988218 @default.
• W3208477687 cites W2076497575 @default.
• W3208477687 cites W2087662066 @default.
• W3208477687 cites W2091667439 @default.
• W3208477687 cites W2094477891 @default.
• W3208477687 cites W2105028602 @default.
• W3208477687 cites W2111957555 @default.
• W3208477687 cites W2115885986 @default.
• W3208477687 cites W2118964113 @default.
• W3208477687 cites W2129611373 @default.
• W3208477687 cites W2139884401 @default.
• W3208477687 cites W2163503448 @default.
• W3208477687 cites W2221731984 @default.
• W3208477687 cites W2399094071 @default.
• W3208477687 cites W2556389549 @default.
• W3208477687 cites W2756212562 @default.
• W3208477687 cites W2811227283 @default.
• W3208477687 cites W2891614594 @default.
• W3208477687 doi "https://doi.org/10.1093/jb/mvab119" @default.
• W3208477687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34718606" @default.
• W3208477687 hasPublicationYear "2021" @default.
• W3208477687 type Work @default.
• W3208477687 sameAs 3208477687 @default.
• W3208477687 citedByCount "2" @default.
• W3208477687 countsByYear W32084776872023 @default.
• W3208477687 crossrefType "journal-article" @default.
• W3208477687 hasAuthorship W3208477687A5006011729 @default.
• W3208477687 hasAuthorship W3208477687A5007717696 @default.
• W3208477687 hasAuthorship W3208477687A5015624012 @default.
• W3208477687 hasAuthorship W3208477687A5044265229 @default.
• W3208477687 hasAuthorship W3208477687A5046107109 @default.
• W3208477687 hasAuthorship W3208477687A5063402092 @default.
• W3208477687 hasAuthorship W3208477687A5065602028 @default.
• W3208477687 hasAuthorship W3208477687A5084931452 @default.
• W3208477687 hasAuthorship W3208477687A5086651873 @default.
• W3208477687 hasAuthorship W3208477687A5088123955 @default.
• W3208477687 hasBestOaLocation W32084776872 @default.
• W3208477687 hasConcept C104317684 @default.
• W3208477687 hasConcept C119157956 @default.
• W3208477687 hasConcept C138488276 @default.
• W3208477687 hasConcept C153911025 @default.
• W3208477687 hasConcept C185592680 @default.
• W3208477687 hasConcept C190062978 @default.
• W3208477687 hasConcept C25602115 @default.
• W3208477687 hasConcept C2780561631 @default.
• W3208477687 hasConcept C28859421 @default.
• W3208477687 hasConcept C54009773 @default.
• W3208477687 hasConcept C54355233 @default.
• W3208477687 hasConcept C55493867 @default.
• W3208477687 hasConcept C81885089 @default.
• W3208477687 hasConcept C86803240 @default.
• W3208477687 hasConcept C95444343 @default.
• W3208477687 hasConceptScore W3208477687C104317684 @default.
• W3208477687 hasConceptScore W3208477687C119157956 @default.
• W3208477687 hasConceptScore W3208477687C138488276 @default.
• W3208477687 hasConceptScore W3208477687C153911025 @default.
• W3208477687 hasConceptScore W3208477687C185592680 @default.
• W3208477687 hasConceptScore W3208477687C190062978 @default.
• W3208477687 hasConceptScore W3208477687C25602115 @default.
• W3208477687 hasConceptScore W3208477687C2780561631 @default.
• W3208477687 hasConceptScore W3208477687C28859421 @default.
• W3208477687 hasConceptScore W3208477687C54009773 @default.
• W3208477687 hasConceptScore W3208477687C54355233 @default.
• W3208477687 hasConceptScore W3208477687C55493867 @default.
• W3208477687 hasConceptScore W3208477687C81885089 @default.
• W3208477687 hasConceptScore W3208477687C86803240 @default.
• W3208477687 hasConceptScore W3208477687C95444343 @default.
• W3208477687 hasIssue "2" @default.

• next