FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208481063> ?p ?o ?g. }

• W3208481063 endingPage "102885" @default.
• W3208481063 startingPage "102885" @default.
• W3208481063 abstract "In this study, the influences of surfactant types, the molar ratio of surfactant and cholesterol, and the molar ratio of drug load and total lipids on the size, zeta potential and drug entrapment efficiency of niosomes were statistically evaluated using a central composite design. Alendronic acid, a bisphosphonate compound was used to study. Stability, in vitro drug release and gastrointestinal permeability improvement of alendronate niosomal dispersion were also studied. The results showed that surfactant types, molar ratios of surfactant to cholesterol and molar ratios of drug load to total lipids had a significant effect on particle size, zeta potential and drug entrapment efficiency of niosomes (P < 0.05). The obtained niosomes were of a unilamellar spherical shape with negative zeta potential values. The niosomes prepared from Span 60 were larger and more entrapment efficient than those prepared from Span 20. In addition, the decrease of molar ratios of Spans and cholesterol resulted in the increase of zeta potential. The particle size and drug entrapment efficiency decrease when the molar ratio of Spans and cholesterol was decreased. Moreover, increase of drug load and total lipid molar ratio resulted in the decrease of zeta potential. However, particle size and drug entrapment efficiency could be increased with increasing molar ratio of drug loading and total lipid. Niosomes prepared from Span 60 showed a slower release rate than those prepared from Span 20. In the stability study, when stored at 4 °C for 90 days, only niosomes prepared from Span 20 have no significant change in particle size, zeta potential and the percentage of drug entrapment. The permeation of alendronate niosomes across Caco-2 cells monolayer showed that the average apparent permeability of alendronic acid from the niosomal dispersion prepared from Span 20 and Span 60 were significantly greater than that of the drug solution. This study revealed that niosomal dispersion can improve the oral bioavailability of alendronic acid." @default.
• W3208481063 created "2021-11-08" @default.
• W3208481063 creator A5030127357 @default.
• W3208481063 creator A5036452453 @default.
• W3208481063 creator A5044558081 @default.
• W3208481063 creator A5083232114 @default.
• W3208481063 date "2022-01-01" @default.
• W3208481063 modified "2023-09-26" @default.
• W3208481063 title "Development of alendronate niosomal delivery system for gastrointestinal permeability improvement" @default.
• W3208481063 cites W1143948794 @default.
• W3208481063 cites W1615191020 @default.
• W3208481063 cites W1966833953 @default.
• W3208481063 cites W1968601352 @default.
• W3208481063 cites W1974120683 @default.
• W3208481063 cites W1981433605 @default.
• W3208481063 cites W1990137419 @default.
• W3208481063 cites W1993890329 @default.
• W3208481063 cites W1995223391 @default.
• W3208481063 cites W1996328211 @default.
• W3208481063 cites W1998259722 @default.
• W3208481063 cites W2002762671 @default.
• W3208481063 cites W2010542506 @default.
• W3208481063 cites W2018785523 @default.
• W3208481063 cites W2021559992 @default.
• W3208481063 cites W2025878451 @default.
• W3208481063 cites W2047405247 @default.
• W3208481063 cites W2062767906 @default.
• W3208481063 cites W2083462231 @default.
• W3208481063 cites W2083592954 @default.
• W3208481063 cites W2084774646 @default.
• W3208481063 cites W2089480064 @default.
• W3208481063 cites W2091170063 @default.
• W3208481063 cites W2158013415 @default.
• W3208481063 cites W2196440566 @default.
• W3208481063 cites W2229883312 @default.
• W3208481063 cites W2317284247 @default.
• W3208481063 cites W2343130116 @default.
• W3208481063 cites W2467161545 @default.
• W3208481063 cites W2468810163 @default.
• W3208481063 cites W2586157008 @default.
• W3208481063 cites W2904162707 @default.
• W3208481063 cites W3109975207 @default.
• W3208481063 cites W757337304 @default.
• W3208481063 doi "https://doi.org/10.1016/j.jddst.2021.102885" @default.
• W3208481063 hasPublicationYear "2022" @default.
• W3208481063 type Work @default.
• W3208481063 sameAs 3208481063 @default.
• W3208481063 citedByCount "0" @default.
• W3208481063 crossrefType "journal-article" @default.
• W3208481063 hasAuthorship W3208481063A5030127357 @default.
• W3208481063 hasAuthorship W3208481063A5036452453 @default.
• W3208481063 hasAuthorship W3208481063A5044558081 @default.
• W3208481063 hasAuthorship W3208481063A5083232114 @default.
• W3208481063 hasConcept C120882062 @default.
• W3208481063 hasConcept C130316041 @default.
• W3208481063 hasConcept C147789679 @default.
• W3208481063 hasConcept C155672457 @default.
• W3208481063 hasConcept C171250308 @default.
• W3208481063 hasConcept C185592680 @default.
• W3208481063 hasConcept C187530423 @default.
• W3208481063 hasConcept C192562407 @default.
• W3208481063 hasConcept C199343813 @default.
• W3208481063 hasConcept C202271784 @default.
• W3208481063 hasConcept C41625074 @default.
• W3208481063 hasConcept C43617362 @default.
• W3208481063 hasConcept C55493867 @default.
• W3208481063 hasConcept C58226133 @default.
• W3208481063 hasConcept C71924100 @default.
• W3208481063 hasConcept C72918618 @default.
• W3208481063 hasConcept C86181022 @default.
• W3208481063 hasConceptScore W3208481063C120882062 @default.
• W3208481063 hasConceptScore W3208481063C130316041 @default.
• W3208481063 hasConceptScore W3208481063C147789679 @default.
• W3208481063 hasConceptScore W3208481063C155672457 @default.
• W3208481063 hasConceptScore W3208481063C171250308 @default.
• W3208481063 hasConceptScore W3208481063C185592680 @default.
• W3208481063 hasConceptScore W3208481063C187530423 @default.
• W3208481063 hasConceptScore W3208481063C192562407 @default.
• W3208481063 hasConceptScore W3208481063C199343813 @default.
• W3208481063 hasConceptScore W3208481063C202271784 @default.
• W3208481063 hasConceptScore W3208481063C41625074 @default.
• W3208481063 hasConceptScore W3208481063C43617362 @default.
• W3208481063 hasConceptScore W3208481063C55493867 @default.
• W3208481063 hasConceptScore W3208481063C58226133 @default.
• W3208481063 hasConceptScore W3208481063C71924100 @default.
• W3208481063 hasConceptScore W3208481063C72918618 @default.
• W3208481063 hasConceptScore W3208481063C86181022 @default.
• W3208481063 hasFunder F4320322401 @default.
• W3208481063 hasFunder F4320322614 @default.
• W3208481063 hasFunder F4320329659 @default.
• W3208481063 hasLocation W32084810631 @default.
• W3208481063 hasOpenAccess W3208481063 @default.
• W3208481063 hasPrimaryLocation W32084810631 @default.
• W3208481063 hasRelatedWork W1988156495 @default.
• W3208481063 hasRelatedWork W2034697702 @default.
• W3208481063 hasRelatedWork W2091254406 @default.
• W3208481063 hasRelatedWork W2560773342 @default.
• W3208481063 hasRelatedWork W2571192017 @default.

• next