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- W3208481441 abstract "<h3>Objectives</h3> The objective of this study is to identify clinicopathologic characteristics associated with non-sentinel lymph node (SLN) metastasis and non-vaginal recurrences in patients with SLN-positive endometrial cancer (EC). <h3>Methods</h3> Consecutive patients with surgically staged EC and at least one positive SLN were included. SLNs were ultra-staged. Positive SLNs were reviewed and patients classified according to the size of the largest SLN metastasis. <h3>Results</h3> 103 patients (36 isolated tumor cells (ITC), 27 micrometastasis, 40 macrometastasis) were included. Multiple positive SLNs were observed in 38.8% of patients. Size of SLN metastasis (adjusted OR (aOR) 3.0 for macrometastasis vs ITC, 95%CI 1.1–8.1), and age (aOR 1.8 per 10-year increase, 95%CI 1.1–3.0) were independent predictors of multiple positive SLNs. Extracapsular compared to intracapsular invasion of the SLN metastasis was significantly associated with multiple positive SLNs at univariate analysis (71.4% vs. 33.7%, p=0.008). Forty-seven percent (18/38) of patients who underwent completion pelvic lymphadenectomy, had additional positive lymph nodes. This was associated with increased size of SLN metastasis (0/8, 5/10, and 13/20 in ITC, micro- and macrometastasis, respectively, p=0.004). SLN macrometastasis (adjusted HR (aHR) 3.4, 95%CI 1.1–11.0), non-endometrioid histology (aHR 5.7, 95%CI 1.9–17.3), and cervical stromal invasion (aHR 9.4, 95%CI 2.9–30.4) were independent predictors of non-vaginal recurrence (table 1). <h3>Conclusions</h3> Size and location of SLN metastasis can predict an increased risk of multiple positive SLNs, non-SLN positive nodes, and non-vaginal recurrence in SLN positive EC patients. These factors should be assessed when considering adjuvant treatment in these high-risk patients." @default.
- W3208481441 created "2021-11-08" @default.
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- W3208481441 date "2021-11-01" @default.
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- W3208481441 title "O005/#190 Where there is smoke, there is fire: understanding the implications of positive sentinel lymph nodes in endometrial cancer" @default.
- W3208481441 doi "https://doi.org/10.1136/ijgc-2021-igcs.5" @default.
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