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- W3208482354 endingPage "178" @default.
- W3208482354 startingPage "147" @default.
- W3208482354 abstract "Aberrant control of acid–base homeostasis is an emerging cancer hallmark that results from adaptation to oncogenic metabolism and tumor microenvironment. It has dramatic consequences, contributing to acquisition of aggressive tumor phenotype and disease progression. Regulation of pH is executed by transporters, exchangers, and pumps mediating ion fluxes in rates dictated by actual physiological needs of tumor cells. However, full performance of the pH-regulation machinery requires carbonic anhydrases (CAs) catalyzing a reaction key to acid-base balance: reversible conversion of carbon dioxide to bicarbonate ion and proton. Here, we provide an overview of known and predicted links of the human CA isoforms to various types of neoplasms and summarize the mechanisms, through which they functionally contribute to cancer. We use the approach, in which data from published papers are complemented by publicly available metadata processed by the GEPIA2 instrument. This allows not only for aligning bioinformatics to experimental evidence (supporting a prominent position of CA IX), but also for prediction of novel correlations that remain to be experimentally proven (such as for CA XIV). With a continuous accumulation of the knowledge, it is now becoming clear that CAs are broadly expressed in tumors and actively participate in cancer development and/or progression." @default.
- W3208482354 created "2021-11-08" @default.
- W3208482354 creator A5007128413 @default.
- W3208482354 creator A5048935719 @default.
- W3208482354 date "2021-01-01" @default.
- W3208482354 modified "2023-09-27" @default.
- W3208482354 title "An Overview of Carbonic Anhydrase-Related Neoplasms" @default.
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