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- W3208487419 abstract "100 years ago, Liepmann highlighted the role of left ventro-dorsal lesions for impairments in conceptual (rather ventral) and motor (more dorsal) related aspects of apraxia. Many studies thereafter attributed to an extended left fronto-temporo-parietal network. Yet, to date there are only few studies that looked at apraxic performance in the selection and application of familiar versus novel tools. In the current study we applied modern voxel-based lesion-symptom mapping (VLSM) to analyze neural correlates of impaired selection and application of familiar versus novel tools. 58 left (LBD) and 51 right brain damaged (RBD) stroke patients participated in the Novel Tools Test (NTT) and the Familiar Tools Test (FTT) of the Diagnostic Instrument for Limb Apraxia (DILA-S). We further assessed performance in control tasks, namely semantic knowledge (BOSU), visuo-spatial working memory (Corsi Block Tapping) and meaningless imitation of gestures (IML). Impaired tool use was most pronounced after LBD. Our VLSM results in the LBD group suggested that selection- versus application-related aspects of praxis and semantics of familiar versus novel tool use can be behaviorally and neuro-anatomically differentiated. For impairments in familiar tool tasks, the major focus of lesion maps was rather ventral while deficiencies in novel tool tasks went along with rather dorsal lesions. Affected selection processes were linked to rather anterior lesions, while impacted application processes went along with rather posterior lesion maps. In our study, particular tool selection processes were rather specific for familiar versus novel tools. Foci for lesion overlaps of experimental and control tasks were noticed ventrally for semantic knowledge and FTT, in fronto-parietal regions for working memory and NTT, and ventro-dorsally for imitation of meaningless gestures and the application of NTT and FTT. We visualized our current interpretation within a neuroanatomical model for apraxia of tool use." @default.
- W3208487419 created "2021-11-08" @default.
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- W3208487419 creator A5064014365 @default.
- W3208487419 creator A5070610122 @default.
- W3208487419 creator A5072043014 @default.
- W3208487419 date "2022-01-01" @default.
- W3208487419 modified "2023-10-05" @default.
- W3208487419 title "100 years after Liepmann–Lesion correlates of diminished selection and application of familiar versus novel tools" @default.
- W3208487419 cites W1215380709 @default.
- W3208487419 cites W1537284115 @default.
- W3208487419 cites W1595033594 @default.
- W3208487419 cites W1635149498 @default.
- W3208487419 cites W1963193125 @default.
- W3208487419 cites W1965491986 @default.
- W3208487419 cites W1967597672 @default.
- W3208487419 cites W1967736337 @default.
- W3208487419 cites W1977297673 @default.
- W3208487419 cites W1978290313 @default.
- W3208487419 cites W1982854986 @default.
- W3208487419 cites W1984917351 @default.
- W3208487419 cites W1986472708 @default.
- W3208487419 cites W1988539867 @default.
- W3208487419 cites W1988880530 @default.
- W3208487419 cites W1989885404 @default.
- W3208487419 cites W1990856279 @default.
- W3208487419 cites W1992101402 @default.
- W3208487419 cites W1993477803 @default.
- W3208487419 cites W1994316000 @default.
- W3208487419 cites W1997201827 @default.
- W3208487419 cites W1997570186 @default.
- W3208487419 cites W1998772241 @default.
- W3208487419 cites W2007158070 @default.
- W3208487419 cites W2009833898 @default.
- W3208487419 cites W2012090015 @default.
- W3208487419 cites W2014966184 @default.
- W3208487419 cites W2017411960 @default.
- W3208487419 cites W2018015521 @default.
- W3208487419 cites W2021436920 @default.
- W3208487419 cites W2031764414 @default.
- W3208487419 cites W2033387209 @default.
- W3208487419 cites W2033940434 @default.
- W3208487419 cites W2035864172 @default.
- W3208487419 cites W2036048616 @default.
- W3208487419 cites W2039694382 @default.
- W3208487419 cites W2041306972 @default.
- W3208487419 cites W2044550444 @default.
- W3208487419 cites W2045543438 @default.
- W3208487419 cites W2046510061 @default.
- W3208487419 cites W2047345533 @default.
- W3208487419 cites W2047824624 @default.
- W3208487419 cites W2048882587 @default.
- W3208487419 cites W2052990283 @default.
- W3208487419 cites W2054339120 @default.
- W3208487419 cites W2055428505 @default.
- W3208487419 cites W2055530531 @default.
- W3208487419 cites W2056124373 @default.
- W3208487419 cites W2057459795 @default.
- W3208487419 cites W2058835519 @default.
- W3208487419 cites W2062499611 @default.
- W3208487419 cites W2063043469 @default.
- W3208487419 cites W2073702460 @default.
- W3208487419 cites W2074895886 @default.
- W3208487419 cites W2075436957 @default.
- W3208487419 cites W2076576536 @default.
- W3208487419 cites W2079719029 @default.
- W3208487419 cites W2080523691 @default.
- W3208487419 cites W2083214669 @default.
- W3208487419 cites W2088727001 @default.
- W3208487419 cites W2090631861 @default.
- W3208487419 cites W2091838012 @default.
- W3208487419 cites W2092439836 @default.
- W3208487419 cites W2096203066 @default.
- W3208487419 cites W2102910053 @default.
- W3208487419 cites W2114931946 @default.
- W3208487419 cites W2115227389 @default.
- W3208487419 cites W2116484132 @default.
- W3208487419 cites W2117878751 @default.
- W3208487419 cites W2118125647 @default.
- W3208487419 cites W2122759009 @default.
- W3208487419 cites W2124777086 @default.
- W3208487419 cites W2126672489 @default.
- W3208487419 cites W2127166669 @default.
- W3208487419 cites W2127445969 @default.
- W3208487419 cites W2133384946 @default.
- W3208487419 cites W2133787218 @default.
- W3208487419 cites W2136469918 @default.
- W3208487419 cites W2136674221 @default.
- W3208487419 cites W2137456982 @default.
- W3208487419 cites W2140068638 @default.
- W3208487419 cites W2149112028 @default.
- W3208487419 cites W2149989625 @default.
- W3208487419 cites W2152670257 @default.
- W3208487419 cites W2153857579 @default.
- W3208487419 cites W2156967573 @default.