FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208492554> ?p ?o ?g. }

• W3208492554 endingPage "e376" @default.
• W3208492554 startingPage "e375" @default.
• W3208492554 abstract "Head and neck (H&N) cancer patients undergoing radiation therapy (RT) experience toxicity and frequently require medical attention through emergency department visits (EDV) and hospital admissions (HA). Frequent hospital encounters potentially delay RT courses, negatively impact patient outcomes, and increase healthcare cost. This study aims to identify patient and treatment factors associated with risk of EDV/HA during H&N RT.This retrospective study included all patients undergoing H&N RT at a single institution from 2009 - 2019. Patients undergoing palliative RT and planned EDV/HA were excluded. All patients underwent definitive or postop RT using IMRT or VMAT. Factors evaluated for association with EDV/HA were concurrent systemic therapy, systemic therapy type, postop RT, AJCC stage, RT for recurrence, RT duration, and primary tumor site. Patient specific factors evaluated included gender, rural location, marital status, smoking status, smokeless tobacco use, and alcohol use severity. EDV/HA were included if they occurred during RT or within one month of RT completion. The primary presenting issue for EDV/HA was recorded for each patient. Analysis included the Mann-Whitney U-test and chi-squared comparisons.A total of 232 H&N cancer patients were included with 93 patients (40%) requiring EDV/HA. Overall, there were 149 EDV/HA recorded. The most common presenting complaints were dysphagia (20%), vomiting/diarrhea (18%), PEG tube issues (9%), swelling/airway issues (7%), aspiration pneumonia (7%), tracheostomy issues (5%), and facial infections (3%). Chemo-RT was administered concurrently to 158 patients (68%) with 113 (49%) receiving platinum-based chemotherapy, 34 (15%) receiving cetuximab, 3 (2%) transitioning between chemotherapy/cetuximab, and 8 (5%) receiving an unknown regimen. Patients receiving chemo-RT were much more likely to require EDV/HA (Likelihood Ratio (LR) = 35.2; P < 0.001). Postop RT was administered with or without systemic therapy to 108 patients (47%). This group was significantly less likely to require EDV/HA (LR = 15.0; P < 0.001). Patients with EDV/HA had a median RT duration of 50 days (IQR, 46 - 56), significantly longer than the median of 45 days (IQR, 42 - 50) in the remainder of the cohort (P < 0.001). AJCC stage only trended to significance and stage I-II disease still accounted for 10% of EDV/HA. Socioeconomic factors, RT for recurrence, and systemic therapy type did not significantly influence EDV/hospital encounters.Patients receiving chemo-RT for H&N cancer were significantly more likely to have EDV/HA resulting in longer overall RT courses. Other treatment factors and patient specific factors were not associated with increased EDV/HA. Proactive management of the most common presenting symptoms in this cohort could minimize hospital encounters and improve outcomes." @default.
• W3208492554 created "2021-11-08" @default.
• W3208492554 creator A5025473170 @default.
• W3208492554 creator A5036676090 @default.
• W3208492554 creator A5040883653 @default.
• W3208492554 creator A5070256571 @default.
• W3208492554 creator A5070512862 @default.
• W3208492554 date "2021-11-01" @default.
• W3208492554 modified "2023-09-27" @default.
• W3208492554 title "Predictors of Emergency Department Visits and Hospital Admissions During Head and Neck Radiation Therapy" @default.
• W3208492554 doi "https://doi.org/10.1016/j.ijrobp.2021.07.1105" @default.
• W3208492554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34701304" @default.
• W3208492554 hasPublicationYear "2021" @default.
• W3208492554 type Work @default.
• W3208492554 sameAs 3208492554 @default.
• W3208492554 citedByCount "0" @default.
• W3208492554 crossrefType "journal-article" @default.
• W3208492554 hasAuthorship W3208492554A5025473170 @default.
• W3208492554 hasAuthorship W3208492554A5036676090 @default.
• W3208492554 hasAuthorship W3208492554A5040883653 @default.
• W3208492554 hasAuthorship W3208492554A5070256571 @default.
• W3208492554 hasAuthorship W3208492554A5070512862 @default.
• W3208492554 hasBestOaLocation W32084925541 @default.
• W3208492554 hasConcept C118552586 @default.
• W3208492554 hasConcept C126322002 @default.
• W3208492554 hasConcept C141071460 @default.
• W3208492554 hasConcept C187212893 @default.
• W3208492554 hasConcept C194828623 @default.
• W3208492554 hasConcept C2776530083 @default.
• W3208492554 hasConcept C2780596822 @default.
• W3208492554 hasConcept C2780724011 @default.
• W3208492554 hasConcept C509974204 @default.
• W3208492554 hasConcept C71924100 @default.
• W3208492554 hasConceptScore W3208492554C118552586 @default.
• W3208492554 hasConceptScore W3208492554C126322002 @default.
• W3208492554 hasConceptScore W3208492554C141071460 @default.
• W3208492554 hasConceptScore W3208492554C187212893 @default.
• W3208492554 hasConceptScore W3208492554C194828623 @default.
• W3208492554 hasConceptScore W3208492554C2776530083 @default.
• W3208492554 hasConceptScore W3208492554C2780596822 @default.
• W3208492554 hasConceptScore W3208492554C2780724011 @default.
• W3208492554 hasConceptScore W3208492554C509974204 @default.
• W3208492554 hasConceptScore W3208492554C71924100 @default.
• W3208492554 hasIssue "3" @default.
• W3208492554 hasLocation W32084925541 @default.
• W3208492554 hasLocation W32084925542 @default.
• W3208492554 hasOpenAccess W3208492554 @default.
• W3208492554 hasPrimaryLocation W32084925541 @default.
• W3208492554 hasRelatedWork W1973403174 @default.
• W3208492554 hasRelatedWork W2062562690 @default.
• W3208492554 hasRelatedWork W2153545068 @default.
• W3208492554 hasRelatedWork W2166400197 @default.
• W3208492554 hasRelatedWork W2748926987 @default.
• W3208492554 hasRelatedWork W2896004006 @default.
• W3208492554 hasRelatedWork W2992800229 @default.
• W3208492554 hasRelatedWork W2996152203 @default.
• W3208492554 hasRelatedWork W3154944956 @default.
• W3208492554 hasRelatedWork W4312129238 @default.
• W3208492554 hasVolume "111" @default.
• W3208492554 isParatext "false" @default.
• W3208492554 isRetracted "false" @default.
• W3208492554 magId "3208492554" @default.
• W3208492554 workType "article" @default.