Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208492739> ?p ?o ?g. }
- W3208492739 abstract "Sry on the Y chromosome is the master switch in sex determination in mammals. It has been well established that Sry encodes a transcription factor that is transiently expressed in somatic cells of male gonad, inducing a series of events that lead to the formation of testes. In the testis of adult mice, Sry is expressed as a circular RNA (circRNA) transcript, a type of noncoding RNA that forms a covalently linked continuous loop. However, the physiological function of this Sry circRNA ( circSry ) remains unknown since its discovery in 1993. Here we show that circSry is mainly expressed in the spermatocytes, but not in mature sperms and Sertoli cells. Loss of circSry led to the reduction of sperm number and the defect of germ cell development. The expression of γH2AX was decreased and failure of XY body formation was noted in circSry KO germ cells. Further study demonstrates that circSry regulates H2AX mRNA indirectly in pachytene spermatocytes through sponging miR-138-5p. Our study demonstrates that, in addition to its well-known sex-determination function, Sry also plays important role in spermatogenesis as a circRNA." @default.
- W3208492739 created "2021-11-08" @default.
- W3208492739 creator A5012718640 @default.
- W3208492739 creator A5014283643 @default.
- W3208492739 creator A5026633627 @default.
- W3208492739 creator A5031315906 @default.
- W3208492739 creator A5041461407 @default.
- W3208492739 creator A5041889208 @default.
- W3208492739 creator A5056850607 @default.
- W3208492739 creator A5060956929 @default.
- W3208492739 creator A5067232661 @default.
- W3208492739 date "2021-10-26" @default.
- W3208492739 modified "2023-09-26" @default.
- W3208492739 title "CircSry regulates spermatogenesis by enhancing γH2AX expression via sponging miR-138-5p" @default.
- W3208492739 cites W1700506044 @default.
- W3208492739 cites W1866220599 @default.
- W3208492739 cites W1966411071 @default.
- W3208492739 cites W1966498224 @default.
- W3208492739 cites W2007969716 @default.
- W3208492739 cites W2008976996 @default.
- W3208492739 cites W2013246689 @default.
- W3208492739 cites W2014705773 @default.
- W3208492739 cites W2015947713 @default.
- W3208492739 cites W2031593782 @default.
- W3208492739 cites W2034305079 @default.
- W3208492739 cites W2046387002 @default.
- W3208492739 cites W2058835062 @default.
- W3208492739 cites W2059265921 @default.
- W3208492739 cites W2062509237 @default.
- W3208492739 cites W2064165694 @default.
- W3208492739 cites W2081087045 @default.
- W3208492739 cites W2108547322 @default.
- W3208492739 cites W2109303819 @default.
- W3208492739 cites W2112001233 @default.
- W3208492739 cites W2117009682 @default.
- W3208492739 cites W2117870306 @default.
- W3208492739 cites W2127734875 @default.
- W3208492739 cites W2141708499 @default.
- W3208492739 cites W2143817569 @default.
- W3208492739 cites W2149930662 @default.
- W3208492739 cites W2160762623 @default.
- W3208492739 cites W2163723846 @default.
- W3208492739 cites W2166820565 @default.
- W3208492739 cites W2170373841 @default.
- W3208492739 cites W2294897294 @default.
- W3208492739 cites W2301925216 @default.
- W3208492739 cites W2567346568 @default.
- W3208492739 cites W2606970705 @default.
- W3208492739 cites W2915433652 @default.
- W3208492739 cites W2949259826 @default.
- W3208492739 cites W2970358232 @default.
- W3208492739 cites W3004073046 @default.
- W3208492739 cites W3090289280 @default.
- W3208492739 doi "https://doi.org/10.1101/2021.10.25.465684" @default.
- W3208492739 hasPublicationYear "2021" @default.
- W3208492739 type Work @default.
- W3208492739 sameAs 3208492739 @default.
- W3208492739 citedByCount "0" @default.
- W3208492739 crossrefType "posted-content" @default.
- W3208492739 hasAuthorship W3208492739A5012718640 @default.
- W3208492739 hasAuthorship W3208492739A5014283643 @default.
- W3208492739 hasAuthorship W3208492739A5026633627 @default.
- W3208492739 hasAuthorship W3208492739A5031315906 @default.
- W3208492739 hasAuthorship W3208492739A5041461407 @default.
- W3208492739 hasAuthorship W3208492739A5041889208 @default.
- W3208492739 hasAuthorship W3208492739A5056850607 @default.
- W3208492739 hasAuthorship W3208492739A5060956929 @default.
- W3208492739 hasAuthorship W3208492739A5067232661 @default.
- W3208492739 hasBestOaLocation W32084927391 @default.
- W3208492739 hasConcept C104317684 @default.
- W3208492739 hasConcept C105580179 @default.
- W3208492739 hasConcept C123765429 @default.
- W3208492739 hasConcept C134018914 @default.
- W3208492739 hasConcept C134305767 @default.
- W3208492739 hasConcept C138885662 @default.
- W3208492739 hasConcept C179926584 @default.
- W3208492739 hasConcept C2778486617 @default.
- W3208492739 hasConcept C2778619154 @default.
- W3208492739 hasConcept C2779122487 @default.
- W3208492739 hasConcept C2780246931 @default.
- W3208492739 hasConcept C2781068068 @default.
- W3208492739 hasConcept C41895202 @default.
- W3208492739 hasConcept C54355233 @default.
- W3208492739 hasConcept C62203573 @default.
- W3208492739 hasConcept C67705224 @default.
- W3208492739 hasConcept C73456138 @default.
- W3208492739 hasConcept C86339819 @default.
- W3208492739 hasConcept C86803240 @default.
- W3208492739 hasConcept C95444343 @default.
- W3208492739 hasConceptScore W3208492739C104317684 @default.
- W3208492739 hasConceptScore W3208492739C105580179 @default.
- W3208492739 hasConceptScore W3208492739C123765429 @default.
- W3208492739 hasConceptScore W3208492739C134018914 @default.
- W3208492739 hasConceptScore W3208492739C134305767 @default.
- W3208492739 hasConceptScore W3208492739C138885662 @default.
- W3208492739 hasConceptScore W3208492739C179926584 @default.
- W3208492739 hasConceptScore W3208492739C2778486617 @default.
- W3208492739 hasConceptScore W3208492739C2778619154 @default.
- W3208492739 hasConceptScore W3208492739C2779122487 @default.
- W3208492739 hasConceptScore W3208492739C2780246931 @default.