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- W3208496717 abstract "Insects are a highly successful group of animals that inhabit almost every habitat and environment on Earth. Part of their success is due to a rapid and highly effective immune response thatidentifies, inactivates, and eliminates pathogens. Insects possess an immune system that showsmany similarities to the innate immune system of vertebrates, but they do not possess anequivalent system to the antibody-mediated adaptive immune response of vertebrates.However, some insect do display a process known as immune priming in which prior exposureto a sublethal dose of a pathogen, or pathogen-derived material, leads to an elevation in theimmune response rendering the insect resistant to a subsequent lethal infection a short time later.This process is mediated by an increase in the density of circulating hemocytes and increasedproduction of antimicrobial peptides. Immune priming is an important survival strategy for certaininsects while other insects that do not show this response may have colony-level behaviors thatmay serve to limit the success of pathogens. Insects are now widely used as in vivo models forstudying microbial pathogens of humans and for assessing the in vivo efficacy of antimicrobialagents. Knowledge of the process of immune priming in insects is essential in these applicationsas it may operate and augment the perceived in vivo antimicrobial activity of novel compounds." @default.
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- W3208496717 date "2020-01-01" @default.
- W3208496717 modified "2023-09-23" @default.
- W3208496717 title "Immune priming: the secret weapon of the insectworldGerard Sheehan, Gemma Farrell & Kevin Kavanagh" @default.
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