FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208523337> ?p ?o ?g. }

• W3208523337 endingPage "99" @default.
• W3208523337 startingPage "93" @default.
• W3208523337 abstract "Exosomes are secreted from a variety of cells and transmit parental cell-derived biomolecules, such as nucleic acids and proteins, to recipient cells in distant organs. In addition to their important roles in both physiological and pathological conditions, exosomes are expected to serve as natural drug carriers without any cytotoxicity, immunogenicity, or tumorigenicity. However, the use of exosomes as drug delivery tools is limited due to the low uptake efficiency of the target cells, insufficient release of the contents from the endosome to the cytosol, and possible adverse effects caused by the delivery to non-target cells. In the present study, we examined the effects of the modification of exosomes with carbonate apatite or a lactose-carrying polymer. Using newly generated monitoring exosomes that contain either firefly luciferase or fused mCherry/enhanced green fluorescent protein, we demonstrated that the modification of exosomes with carbonate apatite improved their release from the endosome into the cytosol in recipient cells. Meanwhile, the modification of exosomes with a lactose-carrying polymer enhanced the selective delivery to parenchymal hepatocytes. These modified exosomes may provide an efficient strategy for macromolecule therapy for incurable diseases that cannot be treated with conventional small-molecule compounds." @default.
• W3208523337 created "2021-11-08" @default.
• W3208523337 creator A5005137443 @default.
• W3208523337 creator A5017023714 @default.
• W3208523337 creator A5024037872 @default.
• W3208523337 creator A5050358516 @default.
• W3208523337 creator A5056791373 @default.
• W3208523337 creator A5065036864 @default.
• W3208523337 creator A5082042143 @default.
• W3208523337 creator A5084925683 @default.
• W3208523337 creator A5085346808 @default.
• W3208523337 date "2021-12-01" @default.
• W3208523337 modified "2023-10-15" @default.
• W3208523337 title "Modification of exosomes with carbonate apatite and a glycan polymer improves transduction efficiency and target cell selectivity" @default.
• W3208523337 cites W1969732227 @default.
• W3208523337 cites W1969842221 @default.
• W3208523337 cites W1982473933 @default.
• W3208523337 cites W1985481708 @default.
• W3208523337 cites W1993855194 @default.
• W3208523337 cites W2036161137 @default.
• W3208523337 cites W2040540972 @default.
• W3208523337 cites W2077950074 @default.
• W3208523337 cites W2104183007 @default.
• W3208523337 cites W2123625253 @default.
• W3208523337 cites W2134344512 @default.
• W3208523337 cites W2178935826 @default.
• W3208523337 cites W2224850118 @default.
• W3208523337 cites W2412145118 @default.
• W3208523337 cites W2588997498 @default.
• W3208523337 cites W2739121979 @default.
• W3208523337 cites W2763110750 @default.
• W3208523337 cites W2786514708 @default.
• W3208523337 cites W2789390897 @default.
• W3208523337 cites W2894280499 @default.
• W3208523337 cites W3036363721 @default.
• W3208523337 cites W3047352808 @default.
• W3208523337 cites W4210409925 @default.
• W3208523337 cites W4249579699 @default.
• W3208523337 doi "https://doi.org/10.1016/j.bbrc.2021.10.063" @default.
• W3208523337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34735885" @default.
• W3208523337 hasPublicationYear "2021" @default.
• W3208523337 type Work @default.
• W3208523337 sameAs 3208523337 @default.
• W3208523337 citedByCount "4" @default.
• W3208523337 countsByYear W32085233372022 @default.
• W3208523337 countsByYear W32085233372023 @default.
• W3208523337 crossrefType "journal-article" @default.
• W3208523337 hasAuthorship W3208523337A5005137443 @default.
• W3208523337 hasAuthorship W3208523337A5017023714 @default.
• W3208523337 hasAuthorship W3208523337A5024037872 @default.
• W3208523337 hasAuthorship W3208523337A5050358516 @default.
• W3208523337 hasAuthorship W3208523337A5056791373 @default.
• W3208523337 hasAuthorship W3208523337A5065036864 @default.
• W3208523337 hasAuthorship W3208523337A5082042143 @default.
• W3208523337 hasAuthorship W3208523337A5084925683 @default.
• W3208523337 hasAuthorship W3208523337A5085346808 @default.
• W3208523337 hasConcept C102747710 @default.
• W3208523337 hasConcept C104317684 @default.
• W3208523337 hasConcept C109316439 @default.
• W3208523337 hasConcept C111335760 @default.
• W3208523337 hasConcept C12554922 @default.
• W3208523337 hasConcept C145059251 @default.
• W3208523337 hasConcept C1491633281 @default.
• W3208523337 hasConcept C178790620 @default.
• W3208523337 hasConcept C185592680 @default.
• W3208523337 hasConcept C202751555 @default.
• W3208523337 hasConcept C20518536 @default.
• W3208523337 hasConcept C2779820397 @default.
• W3208523337 hasConcept C54009773 @default.
• W3208523337 hasConcept C55493867 @default.
• W3208523337 hasConcept C86803240 @default.
• W3208523337 hasConcept C95444343 @default.
• W3208523337 hasConceptScore W3208523337C102747710 @default.
• W3208523337 hasConceptScore W3208523337C104317684 @default.
• W3208523337 hasConceptScore W3208523337C109316439 @default.
• W3208523337 hasConceptScore W3208523337C111335760 @default.
• W3208523337 hasConceptScore W3208523337C12554922 @default.
• W3208523337 hasConceptScore W3208523337C145059251 @default.
• W3208523337 hasConceptScore W3208523337C1491633281 @default.
• W3208523337 hasConceptScore W3208523337C178790620 @default.
• W3208523337 hasConceptScore W3208523337C185592680 @default.
• W3208523337 hasConceptScore W3208523337C202751555 @default.
• W3208523337 hasConceptScore W3208523337C20518536 @default.
• W3208523337 hasConceptScore W3208523337C2779820397 @default.
• W3208523337 hasConceptScore W3208523337C54009773 @default.
• W3208523337 hasConceptScore W3208523337C55493867 @default.
• W3208523337 hasConceptScore W3208523337C86803240 @default.
• W3208523337 hasConceptScore W3208523337C95444343 @default.
• W3208523337 hasFunder F4320311405 @default.
• W3208523337 hasFunder F4320320912 @default.
• W3208523337 hasFunder F4320335515 @default.
• W3208523337 hasLocation W32085233371 @default.
• W3208523337 hasLocation W32085233372 @default.
• W3208523337 hasOpenAccess W3208523337 @default.
• W3208523337 hasPrimaryLocation W32085233371 @default.
• W3208523337 hasRelatedWork W1977613047 @default.
• W3208523337 hasRelatedWork W2001323244 @default.
• W3208523337 hasRelatedWork W2069776708 @default.

• next