Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208529523> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W3208529523 endingPage "147707" @default.
- W3208529523 startingPage "147707" @default.
- W3208529523 abstract "Rats that reliably self-administered cocaine also reliably self-administered the cocaine analog RTI-55 and bupropion. The inter-injection intervals of these dopamine transporter (DAT) inhibitors were regular at a given unit dose and increased as a function of unit dose. However, the mean rate of intake differed widely, ranging from 731 to 459 to 2.1 nmol/kg∙min-1 for bupropion, cocaine and RTI-55 respectively, a dramatic 348-fold range. An analysis of inter-injection intervals as a function of unit dose generated values for the mean satiety threshold of 50.6, 5.1 and 0.7 nmol/kg and t1/2 of 56.7, 9.3 and 255.6 min for bupropion, cocaine and RTI-55, respectively. The difference in rate of intake of bupropion and RTI-55 relative to cocaine is a product of their 0.1 and 7.3 fold difference in PD potency and their 6.1 and 27.5 fold difference in t1/2. Additionally, the relative durations of lever-pressing following termination of drug access correlated with the t1/2 estimates. It is hypothesized this duration represents the time required for the drug concentration to fall from the satiety threshold below the priming threshold (the minimum DAT inhibitor level that will induce lever-pressing). This indicates that the time needed for an animal to cease lever pressing following termination of access to the DAT inhibitor is predominately a function of the PK properties of the agonist. The self-administration behavior paradigm in the context of the compulsion zone theory can be used as a bioassay to determine the PK/PD properties of indirect dopamine receptor agonists." @default.
- W3208529523 created "2021-11-08" @default.
- W3208529523 creator A5000575185 @default.
- W3208529523 creator A5044221159 @default.
- W3208529523 creator A5066893861 @default.
- W3208529523 date "2022-01-01" @default.
- W3208529523 modified "2023-10-14" @default.
- W3208529523 title "The compulsion zone explains the self-administration of cocaine, RTI-55 and bupropion in rats" @default.
- W3208529523 cites W1983083650 @default.
- W3208529523 cites W1985527943 @default.
- W3208529523 cites W1996277070 @default.
- W3208529523 cites W2008710986 @default.
- W3208529523 cites W2048423858 @default.
- W3208529523 cites W2056507785 @default.
- W3208529523 cites W2060173794 @default.
- W3208529523 cites W2067382805 @default.
- W3208529523 cites W2068575298 @default.
- W3208529523 cites W2081337051 @default.
- W3208529523 cites W2085923637 @default.
- W3208529523 cites W2087762384 @default.
- W3208529523 cites W2121357466 @default.
- W3208529523 cites W2139501230 @default.
- W3208529523 cites W2312609348 @default.
- W3208529523 cites W2531506904 @default.
- W3208529523 doi "https://doi.org/10.1016/j.brainres.2021.147707" @default.
- W3208529523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34736890" @default.
- W3208529523 hasPublicationYear "2022" @default.
- W3208529523 type Work @default.
- W3208529523 sameAs 3208529523 @default.
- W3208529523 citedByCount "2" @default.
- W3208529523 countsByYear W32085295232022 @default.
- W3208529523 countsByYear W32085295232023 @default.
- W3208529523 crossrefType "journal-article" @default.
- W3208529523 hasAuthorship W3208529523A5000575185 @default.
- W3208529523 hasAuthorship W3208529523A5044221159 @default.
- W3208529523 hasAuthorship W3208529523A5066893861 @default.
- W3208529523 hasConcept C126322002 @default.
- W3208529523 hasConcept C137183658 @default.
- W3208529523 hasConcept C142724271 @default.
- W3208529523 hasConcept C151730666 @default.
- W3208529523 hasConcept C15744967 @default.
- W3208529523 hasConcept C2776755682 @default.
- W3208529523 hasConcept C2777843972 @default.
- W3208529523 hasConcept C2778555786 @default.
- W3208529523 hasConcept C2779343474 @default.
- W3208529523 hasConcept C2779908668 @default.
- W3208529523 hasConcept C2908949072 @default.
- W3208529523 hasConcept C42219234 @default.
- W3208529523 hasConcept C513476851 @default.
- W3208529523 hasConcept C71924100 @default.
- W3208529523 hasConcept C86803240 @default.
- W3208529523 hasConcept C98274493 @default.
- W3208529523 hasConceptScore W3208529523C126322002 @default.
- W3208529523 hasConceptScore W3208529523C137183658 @default.
- W3208529523 hasConceptScore W3208529523C142724271 @default.
- W3208529523 hasConceptScore W3208529523C151730666 @default.
- W3208529523 hasConceptScore W3208529523C15744967 @default.
- W3208529523 hasConceptScore W3208529523C2776755682 @default.
- W3208529523 hasConceptScore W3208529523C2777843972 @default.
- W3208529523 hasConceptScore W3208529523C2778555786 @default.
- W3208529523 hasConceptScore W3208529523C2779343474 @default.
- W3208529523 hasConceptScore W3208529523C2779908668 @default.
- W3208529523 hasConceptScore W3208529523C2908949072 @default.
- W3208529523 hasConceptScore W3208529523C42219234 @default.
- W3208529523 hasConceptScore W3208529523C513476851 @default.
- W3208529523 hasConceptScore W3208529523C71924100 @default.
- W3208529523 hasConceptScore W3208529523C86803240 @default.
- W3208529523 hasConceptScore W3208529523C98274493 @default.
- W3208529523 hasFunder F4320332161 @default.
- W3208529523 hasLocation W32085295231 @default.
- W3208529523 hasLocation W32085295232 @default.
- W3208529523 hasOpenAccess W3208529523 @default.
- W3208529523 hasPrimaryLocation W32085295231 @default.
- W3208529523 hasRelatedWork W1966148872 @default.
- W3208529523 hasRelatedWork W1973576252 @default.
- W3208529523 hasRelatedWork W1987455074 @default.
- W3208529523 hasRelatedWork W1993317188 @default.
- W3208529523 hasRelatedWork W1997975262 @default.
- W3208529523 hasRelatedWork W2019484765 @default.
- W3208529523 hasRelatedWork W2030104137 @default.
- W3208529523 hasRelatedWork W2068040290 @default.
- W3208529523 hasRelatedWork W2072967788 @default.
- W3208529523 hasRelatedWork W3174510254 @default.
- W3208529523 hasVolume "1774" @default.
- W3208529523 isParatext "false" @default.
- W3208529523 isRetracted "false" @default.
- W3208529523 magId "3208529523" @default.
- W3208529523 workType "article" @default.