Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208538596> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W3208538596 endingPage "S52" @default.
- W3208538596 startingPage "S51" @default.
- W3208538596 abstract "Occult non-localized disease (N1 or M1) at the time of definitive treatment of high-risk prostate cancer (HR-PCa) underlies most treatment failures. We recently developed a nomogram tuned to the identification of non-localized disease on prostate specific membrane antigen PET/CT (PSMA PET/CT) in patients with cN0M0 HR-PCa by conventional imaging, which incorporates iPSA, percent positive core on biopsy, Gleason Grade and cT stage. We systematically compared the prognostic performance of the PSMA nomogram against other validated risk stratification tools for HR-PCa.We identified 5275 men from a multi-institutional database treated with radical prostatectomy (55%), external beam radiation therapy (EBRT, 31%), or EBRT and brachytherapy (14%). The prognostic performance of the PSMA nomogram was compared against the STAR-CAP score, the Cancer of the Prostate Risk Assessment (CAPRA) score, Cambridge Prognostic Groups (CPG) risk group, and Memorial Sloan Kettering Cancer Center (MSKCC) nomogram of 5-year recurrence probability. Accuracy was determined for 5- and 10-year distant metastasis (DM) and prostate cancer specific mortality (PCSM) using the concordance index (C-index).Median follow-up was 50.3 months (interquartile range 28.1-84.5 months). Overall, 16.1% developed DM, and 4.6% died from PCa. C-indices for the PSMA nomogram were 0.67 and 0.67 for 5- and 10-year DM, and 0.69 and 0.73 for 5- and 10-year PCSM, respectively. The PSMA nomogram outperformed CAPRA, CPG, and MSKCC for all endpoints, outperformed STAR-CAP for 10-year DM, and performed similarly to STAR-CAP for all other endpoints (see Table). The comparative performance between the tools was generally maintained at different follow-up times and in subgroup analyses stratified by primary treatment modalities.A nomogram tuned to the detection of non-localized disease on PSMA/PET in HR-PCa patients is significantly prognostic of important clinical endpoints, with performance comparable to STAR-CAP and superior to other tools. These data strongly suggest that upstaging based on PSMA PET/CT provides clinically relevant information and warrant prospective validation." @default.
- W3208538596 created "2021-11-08" @default.
- W3208538596 creator A5001069772 @default.
- W3208538596 creator A5004874300 @default.
- W3208538596 creator A5012025332 @default.
- W3208538596 creator A5012794522 @default.
- W3208538596 creator A5020809971 @default.
- W3208538596 creator A5022287984 @default.
- W3208538596 creator A5023100809 @default.
- W3208538596 creator A5026969717 @default.
- W3208538596 creator A5030545703 @default.
- W3208538596 creator A5031144801 @default.
- W3208538596 creator A5040908498 @default.
- W3208538596 creator A5049646055 @default.
- W3208538596 creator A5067282152 @default.
- W3208538596 creator A5067626033 @default.
- W3208538596 creator A5070623757 @default.
- W3208538596 creator A5076238068 @default.
- W3208538596 creator A5077141876 @default.
- W3208538596 creator A5078447958 @default.
- W3208538596 creator A5083311052 @default.
- W3208538596 creator A5087189944 @default.
- W3208538596 date "2021-11-01" @default.
- W3208538596 modified "2023-10-18" @default.
- W3208538596 title "Prognostic Significance of the Risk of Non-localized Disease on PSMA/PET: Comparative Performance of a Novel, PSMA/PET-Derived Risk Stratification Tool for High-Risk Prostate Cancer in a Large, Multi-Institutional Cohort" @default.
- W3208538596 doi "https://doi.org/10.1016/j.ijrobp.2021.07.135" @default.
- W3208538596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34700573" @default.
- W3208538596 hasPublicationYear "2021" @default.
- W3208538596 type Work @default.
- W3208538596 sameAs 3208538596 @default.
- W3208538596 citedByCount "2" @default.
- W3208538596 countsByYear W32085385962021 @default.
- W3208538596 countsByYear W32085385962022 @default.
- W3208538596 crossrefType "journal-article" @default.
- W3208538596 hasAuthorship W3208538596A5001069772 @default.
- W3208538596 hasAuthorship W3208538596A5004874300 @default.
- W3208538596 hasAuthorship W3208538596A5012025332 @default.
- W3208538596 hasAuthorship W3208538596A5012794522 @default.
- W3208538596 hasAuthorship W3208538596A5020809971 @default.
- W3208538596 hasAuthorship W3208538596A5022287984 @default.
- W3208538596 hasAuthorship W3208538596A5023100809 @default.
- W3208538596 hasAuthorship W3208538596A5026969717 @default.
- W3208538596 hasAuthorship W3208538596A5030545703 @default.
- W3208538596 hasAuthorship W3208538596A5031144801 @default.
- W3208538596 hasAuthorship W3208538596A5040908498 @default.
- W3208538596 hasAuthorship W3208538596A5049646055 @default.
- W3208538596 hasAuthorship W3208538596A5067282152 @default.
- W3208538596 hasAuthorship W3208538596A5067626033 @default.
- W3208538596 hasAuthorship W3208538596A5070623757 @default.
- W3208538596 hasAuthorship W3208538596A5076238068 @default.
- W3208538596 hasAuthorship W3208538596A5077141876 @default.
- W3208538596 hasAuthorship W3208538596A5078447958 @default.
- W3208538596 hasAuthorship W3208538596A5083311052 @default.
- W3208538596 hasAuthorship W3208538596A5087189944 @default.
- W3208538596 hasBestOaLocation W32085385961 @default.
- W3208538596 hasConcept C121608353 @default.
- W3208538596 hasConcept C126322002 @default.
- W3208538596 hasConcept C126838900 @default.
- W3208538596 hasConcept C143998085 @default.
- W3208538596 hasConcept C2777008409 @default.
- W3208538596 hasConcept C2778162587 @default.
- W3208538596 hasConcept C2779466945 @default.
- W3208538596 hasConcept C2780192828 @default.
- W3208538596 hasConcept C34626388 @default.
- W3208538596 hasConcept C71924100 @default.
- W3208538596 hasConceptScore W3208538596C121608353 @default.
- W3208538596 hasConceptScore W3208538596C126322002 @default.
- W3208538596 hasConceptScore W3208538596C126838900 @default.
- W3208538596 hasConceptScore W3208538596C143998085 @default.
- W3208538596 hasConceptScore W3208538596C2777008409 @default.
- W3208538596 hasConceptScore W3208538596C2778162587 @default.
- W3208538596 hasConceptScore W3208538596C2779466945 @default.
- W3208538596 hasConceptScore W3208538596C2780192828 @default.
- W3208538596 hasConceptScore W3208538596C34626388 @default.
- W3208538596 hasConceptScore W3208538596C71924100 @default.
- W3208538596 hasIssue "3" @default.
- W3208538596 hasLocation W32085385961 @default.
- W3208538596 hasLocation W32085385962 @default.
- W3208538596 hasOpenAccess W3208538596 @default.
- W3208538596 hasPrimaryLocation W32085385961 @default.
- W3208538596 hasRelatedWork W1515906819 @default.
- W3208538596 hasRelatedWork W1968443701 @default.
- W3208538596 hasRelatedWork W2037626711 @default.
- W3208538596 hasRelatedWork W2042840790 @default.
- W3208538596 hasRelatedWork W2093490499 @default.
- W3208538596 hasRelatedWork W2093890911 @default.
- W3208538596 hasRelatedWork W2121281968 @default.
- W3208538596 hasRelatedWork W2172257731 @default.
- W3208538596 hasRelatedWork W2400077903 @default.
- W3208538596 hasRelatedWork W2890771610 @default.
- W3208538596 hasVolume "111" @default.
- W3208538596 isParatext "false" @default.
- W3208538596 isRetracted "false" @default.
- W3208538596 magId "3208538596" @default.
- W3208538596 workType "article" @default.