Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208545198> ?p ?o ?g. }
- W3208545198 endingPage "107392" @default.
- W3208545198 startingPage "107392" @default.
- W3208545198 abstract "It has been shown that an arginine-glycine-aspartic acid (RGD) modified pH-triggered delivery system for the urokinase-type plasminogen activator (uPA) is resistant to enzymatic degradation and improves thrombolytic ability in vitro. Herein, we aimed to compare the thrombolytic efficacies of uPA-oxidized dextran (Oxd)-RGD and uPA using a rat model of middle cerebral ischemia occlusion (MCAO) in vivo. We found that the uPA-Oxd conjugates delayed the release of active uPA after MCAO. Thus, the rats treated with uPA-Oxd-RGD showed significantly decreased neurological deficits and infarct volume compared with those of the rats treated with uPA alone after MCAO. Furthermore, the administration of uPA-Oxd-RGD attenuated blood–brain barrier disruption and downregulated matrix metalloproteinase expression while upregulating the expression of tight junction proteins. In addition, uPA-Oxd-RGD inhibited apoptosis by suppressing pro-apoptotic caspase expression. These results suggest that the administration of uPA-Oxd-RGD is a more effective intervention in an MCAO model than uPA alone and that the pH changes in the brain tissue after an ischemic stroke may be a novel thrombolytic target." @default.
- W3208545198 created "2021-11-08" @default.
- W3208545198 creator A5000042296 @default.
- W3208545198 creator A5027937292 @default.
- W3208545198 creator A5034266315 @default.
- W3208545198 creator A5036027881 @default.
- W3208545198 creator A5045545221 @default.
- W3208545198 creator A5046513315 @default.
- W3208545198 creator A5048183413 @default.
- W3208545198 creator A5057342639 @default.
- W3208545198 creator A5061357977 @default.
- W3208545198 creator A5067028141 @default.
- W3208545198 creator A5067661439 @default.
- W3208545198 creator A5086644882 @default.
- W3208545198 date "2021-10-01" @default.
- W3208545198 modified "2023-10-02" @default.
- W3208545198 title "In-vivo thrombolytic efficacy of RGD modified protein-polymer conjugated urokinase nanogels" @default.
- W3208545198 cites W1476239914 @default.
- W3208545198 cites W1723097356 @default.
- W3208545198 cites W1967021615 @default.
- W3208545198 cites W1968715532 @default.
- W3208545198 cites W1976467696 @default.
- W3208545198 cites W1986228861 @default.
- W3208545198 cites W2016955792 @default.
- W3208545198 cites W2021867771 @default.
- W3208545198 cites W2024965701 @default.
- W3208545198 cites W2043623141 @default.
- W3208545198 cites W2045483750 @default.
- W3208545198 cites W2045835005 @default.
- W3208545198 cites W2049138578 @default.
- W3208545198 cites W2056283605 @default.
- W3208545198 cites W2060279158 @default.
- W3208545198 cites W2061985128 @default.
- W3208545198 cites W2066096456 @default.
- W3208545198 cites W2081261666 @default.
- W3208545198 cites W2083788705 @default.
- W3208545198 cites W2111982133 @default.
- W3208545198 cites W2116951446 @default.
- W3208545198 cites W2125683177 @default.
- W3208545198 cites W2126634468 @default.
- W3208545198 cites W2129262403 @default.
- W3208545198 cites W2141002268 @default.
- W3208545198 cites W2148992136 @default.
- W3208545198 cites W2159590405 @default.
- W3208545198 cites W2162189519 @default.
- W3208545198 cites W2187679533 @default.
- W3208545198 cites W2284307260 @default.
- W3208545198 cites W2346074453 @default.
- W3208545198 cites W2554880605 @default.
- W3208545198 cites W2597588061 @default.
- W3208545198 cites W2748549515 @default.
- W3208545198 cites W2754764673 @default.
- W3208545198 cites W2804095337 @default.
- W3208545198 cites W2899125760 @default.
- W3208545198 cites W2899197889 @default.
- W3208545198 cites W2903086198 @default.
- W3208545198 cites W2912417833 @default.
- W3208545198 cites W2913630790 @default.
- W3208545198 cites W2922168488 @default.
- W3208545198 cites W2960975759 @default.
- W3208545198 cites W2999465467 @default.
- W3208545198 cites W3000241964 @default.
- W3208545198 cites W3020168806 @default.
- W3208545198 cites W3090692722 @default.
- W3208545198 cites W3104682194 @default.
- W3208545198 cites W3116738485 @default.
- W3208545198 cites W3128649145 @default.
- W3208545198 cites W3139366746 @default.
- W3208545198 doi "https://doi.org/10.1016/j.polymertesting.2021.107392" @default.
- W3208545198 hasPublicationYear "2021" @default.
- W3208545198 type Work @default.
- W3208545198 sameAs 3208545198 @default.
- W3208545198 citedByCount "1" @default.
- W3208545198 countsByYear W32085451982023 @default.
- W3208545198 crossrefType "journal-article" @default.
- W3208545198 hasAuthorship W3208545198A5000042296 @default.
- W3208545198 hasAuthorship W3208545198A5027937292 @default.
- W3208545198 hasAuthorship W3208545198A5034266315 @default.
- W3208545198 hasAuthorship W3208545198A5036027881 @default.
- W3208545198 hasAuthorship W3208545198A5045545221 @default.
- W3208545198 hasAuthorship W3208545198A5046513315 @default.
- W3208545198 hasAuthorship W3208545198A5048183413 @default.
- W3208545198 hasAuthorship W3208545198A5057342639 @default.
- W3208545198 hasAuthorship W3208545198A5061357977 @default.
- W3208545198 hasAuthorship W3208545198A5067028141 @default.
- W3208545198 hasAuthorship W3208545198A5067661439 @default.
- W3208545198 hasAuthorship W3208545198A5086644882 @default.
- W3208545198 hasBestOaLocation W32085451981 @default.
- W3208545198 hasConcept C109523444 @default.
- W3208545198 hasConcept C126322002 @default.
- W3208545198 hasConcept C150903083 @default.
- W3208545198 hasConcept C185592680 @default.
- W3208545198 hasConcept C207001950 @default.
- W3208545198 hasConcept C2776572282 @default.
- W3208545198 hasConcept C2776892390 @default.
- W3208545198 hasConcept C2778402981 @default.
- W3208545198 hasConcept C2779679481 @default.
- W3208545198 hasConcept C502942594 @default.