FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208548401> ?p ?o ?g. }

• W3208548401 endingPage "11522" @default.
• W3208548401 startingPage "11522" @default.
• W3208548401 abstract "The fact that Parkinson's disease (PD) pathologies are well advanced in most PD patients by the time of clinical elucidation attests to the importance of early diagnosis. Our attempt to achieve this has capitalized on our previous finding that GM1 ganglioside is expressed at subnormal levels in virtually all tissues of sporadic PD (sPD) patients including blood cells. GM1 is present in most vertebrate cells, is especially abundant in neurons where it was shown essential for their effective functioning and long term viability. We have utilized peripheral blood mononuclear cells (PBMCs) which, despite their low GM1, we found to be significantly lower in sPD patients compared to age-matched healthy controls. To quantify GM1 (and GD1a) we used high performance thin-layer chromatography combined with cholera toxin B linked to horseradish peroxidase, followed by densitometric quantification. GM1 was also deficient in PBMCs from PD patients with mutations in the glucocerebrosidase gene (PD-GBA), apparently even lower than in sPD. Reasons are given why we believe these results obtained with patients manifesting fully developed PD will apply as well to PD patients in preclinical stages-a topic for future study. We also suggest that these findings point to a potential disease altering therapy for PD once the early diagnosis is established." @default.
• W3208548401 created "2021-11-08" @default.
• W3208548401 creator A5008312130 @default.
• W3208548401 creator A5027791328 @default.
• W3208548401 creator A5028923571 @default.
• W3208548401 creator A5037098776 @default.
• W3208548401 creator A5062460009 @default.
• W3208548401 date "2021-10-26" @default.
• W3208548401 modified "2023-10-18" @default.
• W3208548401 title "Subnormal GM1 in PBMCs: Promise for Early Diagnosis of Parkinson’s Disease?" @default.
• W3208548401 cites W1587041537 @default.
• W3208548401 cites W1981426567 @default.
• W3208548401 cites W1982540226 @default.
• W3208548401 cites W1989569167 @default.
• W3208548401 cites W2003647394 @default.
• W3208548401 cites W2013142876 @default.
• W3208548401 cites W2014871422 @default.
• W3208548401 cites W2016374423 @default.
• W3208548401 cites W2028911868 @default.
• W3208548401 cites W2036428426 @default.
• W3208548401 cites W2055472916 @default.
• W3208548401 cites W2059572565 @default.
• W3208548401 cites W2062989663 @default.
• W3208548401 cites W2066170812 @default.
• W3208548401 cites W2083685908 @default.
• W3208548401 cites W2087598124 @default.
• W3208548401 cites W2095764561 @default.
• W3208548401 cites W2097342284 @default.
• W3208548401 cites W2110127543 @default.
• W3208548401 cites W2118428015 @default.
• W3208548401 cites W2123862011 @default.
• W3208548401 cites W2136230100 @default.
• W3208548401 cites W2144297520 @default.
• W3208548401 cites W2148694419 @default.
• W3208548401 cites W2152575748 @default.
• W3208548401 cites W2487594204 @default.
• W3208548401 cites W2516933519 @default.
• W3208548401 cites W2793164739 @default.
• W3208548401 cites W2808399879 @default.
• W3208548401 cites W2809427654 @default.
• W3208548401 cites W2896122983 @default.
• W3208548401 cites W2903116634 @default.
• W3208548401 cites W2904404980 @default.
• W3208548401 cites W2950103628 @default.
• W3208548401 cites W2973720548 @default.
• W3208548401 cites W2986932567 @default.
• W3208548401 cites W3003365674 @default.
• W3208548401 cites W3003392730 @default.
• W3208548401 cites W3009486254 @default.
• W3208548401 cites W3015663834 @default.
• W3208548401 cites W3037620725 @default.
• W3208548401 doi "https://doi.org/10.3390/ijms222111522" @default.
• W3208548401 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8583888" @default.
• W3208548401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34768952" @default.
• W3208548401 hasPublicationYear "2021" @default.
• W3208548401 type Work @default.
• W3208548401 sameAs 3208548401 @default.
• W3208548401 citedByCount "7" @default.
• W3208548401 countsByYear W32085484012022 @default.
• W3208548401 countsByYear W32085484012023 @default.
• W3208548401 crossrefType "journal-article" @default.
• W3208548401 hasAuthorship W3208548401A5008312130 @default.
• W3208548401 hasAuthorship W3208548401A5027791328 @default.
• W3208548401 hasAuthorship W3208548401A5028923571 @default.
• W3208548401 hasAuthorship W3208548401A5037098776 @default.
• W3208548401 hasAuthorship W3208548401A5062460009 @default.
• W3208548401 hasBestOaLocation W32085484011 @default.
• W3208548401 hasConcept C126322002 @default.
• W3208548401 hasConcept C137061746 @default.
• W3208548401 hasConcept C202751555 @default.
• W3208548401 hasConcept C203014093 @default.
• W3208548401 hasConcept C2777331542 @default.
• W3208548401 hasConcept C2779134260 @default.
• W3208548401 hasConcept C2779734285 @default.
• W3208548401 hasConcept C55493867 @default.
• W3208548401 hasConcept C71924100 @default.
• W3208548401 hasConcept C86803240 @default.
• W3208548401 hasConceptScore W3208548401C126322002 @default.
• W3208548401 hasConceptScore W3208548401C137061746 @default.
• W3208548401 hasConceptScore W3208548401C202751555 @default.
• W3208548401 hasConceptScore W3208548401C203014093 @default.
• W3208548401 hasConceptScore W3208548401C2777331542 @default.
• W3208548401 hasConceptScore W3208548401C2779134260 @default.
• W3208548401 hasConceptScore W3208548401C2779734285 @default.
• W3208548401 hasConceptScore W3208548401C55493867 @default.
• W3208548401 hasConceptScore W3208548401C71924100 @default.
• W3208548401 hasConceptScore W3208548401C86803240 @default.
• W3208548401 hasIssue "21" @default.
• W3208548401 hasLocation W32085484011 @default.
• W3208548401 hasLocation W32085484012 @default.
• W3208548401 hasLocation W32085484013 @default.
• W3208548401 hasLocation W32085484014 @default.
• W3208548401 hasOpenAccess W3208548401 @default.
• W3208548401 hasPrimaryLocation W32085484011 @default.
• W3208548401 hasRelatedWork W1986307200 @default.
• W3208548401 hasRelatedWork W2087976276 @default.
• W3208548401 hasRelatedWork W2416973532 @default.
• W3208548401 hasRelatedWork W2609134097 @default.

• next