Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208551226> ?p ?o ?g. }
- W3208551226 abstract "Benzophenones are widely supplemented in personal care products, but little is known about its neurodevelopmental toxicity. The previous epidemiological study discovered a negative correlation between maternal exposure to a benzophenone metabolite 4-hydroxybenzophenone (4HBP) and child's neurodevelopment, yet the causal relationship and detailed mechanism remain to be defined. Here, it is reported that prenatal, but not postnatal, exposure to environmentally relevant level of 4HBP impairs hippocampus development and causes cognitive dysfunction in offspring mice. Transcriptomic analyses reveal that 4HBP induces the endoplasmic reticulum stress-induced apoptotic signaling and inflammatory response in hippocampal neural stem cells. Mechanistically, 4HBP exposure activates protein kinase R-like ER kinase (PERK) signaling, which induces CHOP, inhibits IκB translation, and transactivates p65, thereby promoting inflammation and apoptosis on multiple levels. Importantly, genetic or pharmacological inhibition of PERK pathway significantly attenuates 4HBP-induced NFκB signaling and neurodevelopmental abnormalities in mice and in a human brain organoid model. The study uncovers the neurodevelopmental toxicity of BP and cautions its exposure during pregnancy." @default.
- W3208551226 created "2021-11-08" @default.
- W3208551226 creator A5001276137 @default.
- W3208551226 creator A5005002539 @default.
- W3208551226 creator A5013486666 @default.
- W3208551226 creator A5013864927 @default.
- W3208551226 creator A5014182741 @default.
- W3208551226 creator A5020375378 @default.
- W3208551226 creator A5021756731 @default.
- W3208551226 creator A5025653081 @default.
- W3208551226 creator A5035126544 @default.
- W3208551226 creator A5042079141 @default.
- W3208551226 creator A5042184569 @default.
- W3208551226 creator A5044042665 @default.
- W3208551226 creator A5047656220 @default.
- W3208551226 creator A5048877164 @default.
- W3208551226 creator A5063891533 @default.
- W3208551226 creator A5066705400 @default.
- W3208551226 creator A5069153972 @default.
- W3208551226 creator A5071558600 @default.
- W3208551226 creator A5083052946 @default.
- W3208551226 date "2021-10-28" @default.
- W3208551226 modified "2023-10-01" @default.
- W3208551226 title "Maternal Benzophenone Exposure Impairs Hippocampus Development and Cognitive Function in Mouse Offspring" @default.
- W3208551226 cites W1977603207 @default.
- W3208551226 cites W1992090041 @default.
- W3208551226 cites W1994580609 @default.
- W3208551226 cites W1998596632 @default.
- W3208551226 cites W1999574084 @default.
- W3208551226 cites W1999782291 @default.
- W3208551226 cites W2001399725 @default.
- W3208551226 cites W2007561188 @default.
- W3208551226 cites W2008398629 @default.
- W3208551226 cites W2036030316 @default.
- W3208551226 cites W2042007511 @default.
- W3208551226 cites W2084517914 @default.
- W3208551226 cites W2085410788 @default.
- W3208551226 cites W2090556647 @default.
- W3208551226 cites W2091046448 @default.
- W3208551226 cites W2094551731 @default.
- W3208551226 cites W2101786871 @default.
- W3208551226 cites W2118483041 @default.
- W3208551226 cites W2120806558 @default.
- W3208551226 cites W2127684300 @default.
- W3208551226 cites W2130410032 @default.
- W3208551226 cites W2143084720 @default.
- W3208551226 cites W2146512944 @default.
- W3208551226 cites W2147355744 @default.
- W3208551226 cites W2170551349 @default.
- W3208551226 cites W2189938228 @default.
- W3208551226 cites W2263498456 @default.
- W3208551226 cites W2461952548 @default.
- W3208551226 cites W2527131525 @default.
- W3208551226 cites W2592811885 @default.
- W3208551226 cites W2618219849 @default.
- W3208551226 cites W2749778917 @default.
- W3208551226 cites W2767328345 @default.
- W3208551226 cites W2775715128 @default.
- W3208551226 cites W2791060250 @default.
- W3208551226 cites W2806469347 @default.
- W3208551226 cites W2811338039 @default.
- W3208551226 cites W2901866608 @default.
- W3208551226 cites W2904644432 @default.
- W3208551226 cites W2913738584 @default.
- W3208551226 cites W2921815679 @default.
- W3208551226 cites W2982160829 @default.
- W3208551226 cites W2999849152 @default.
- W3208551226 cites W3030834164 @default.
- W3208551226 cites W3037538172 @default.
- W3208551226 cites W3048768037 @default.
- W3208551226 cites W3117831080 @default.
- W3208551226 cites W3134145257 @default.
- W3208551226 cites W3158218005 @default.
- W3208551226 doi "https://doi.org/10.1002/advs.202102686" @default.
- W3208551226 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34713618" @default.
- W3208551226 hasPublicationYear "2021" @default.
- W3208551226 type Work @default.
- W3208551226 sameAs 3208551226 @default.
- W3208551226 citedByCount "2" @default.
- W3208551226 countsByYear W32085512262023 @default.
- W3208551226 crossrefType "journal-article" @default.
- W3208551226 hasAuthorship W3208551226A5001276137 @default.
- W3208551226 hasAuthorship W3208551226A5005002539 @default.
- W3208551226 hasAuthorship W3208551226A5013486666 @default.
- W3208551226 hasAuthorship W3208551226A5013864927 @default.
- W3208551226 hasAuthorship W3208551226A5014182741 @default.
- W3208551226 hasAuthorship W3208551226A5020375378 @default.
- W3208551226 hasAuthorship W3208551226A5021756731 @default.
- W3208551226 hasAuthorship W3208551226A5025653081 @default.
- W3208551226 hasAuthorship W3208551226A5035126544 @default.
- W3208551226 hasAuthorship W3208551226A5042079141 @default.
- W3208551226 hasAuthorship W3208551226A5042184569 @default.
- W3208551226 hasAuthorship W3208551226A5044042665 @default.
- W3208551226 hasAuthorship W3208551226A5047656220 @default.
- W3208551226 hasAuthorship W3208551226A5048877164 @default.
- W3208551226 hasAuthorship W3208551226A5063891533 @default.
- W3208551226 hasAuthorship W3208551226A5066705400 @default.
- W3208551226 hasAuthorship W3208551226A5069153972 @default.
- W3208551226 hasAuthorship W3208551226A5071558600 @default.
- W3208551226 hasAuthorship W3208551226A5083052946 @default.