Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208552227> ?p ?o ?g. }
- W3208552227 endingPage "127600" @default.
- W3208552227 startingPage "127600" @default.
- W3208552227 abstract "Parental environmental copper (Cu) exposure is widespread, causing problems for sustainability of fish populations, and epigenetics is suggested to be fundamental during the process, but the mechanism is scarcely reported. Here, we describe the effects of parental environmental Cu exposure on zebrafish developmental abnormality in subsequent generation. This study demonstrated for the first time that: 1. offspring from Cu-stressed paternal adult zebrafish showed developmental defects in the nervous and digestive system and changes in transcriptome; 2. Cu-induced alterations in sperm methylome and transcriptome could induce loci-specific alterations in DNA methylome and corresponding changes in the related gene transcription in offspring; 3. differentially methylated regions in pmpcb, crebl2 and tab2 promoters acted pivotally in their transcription; 4. pmpcb, crebl2 and tab2 are key individual contributors to parental Cu exposure-induced developmental defects in the nervous system, retina and digestive system of the offspring. Those data revealed that Cu-induced alterations in sperm methylome and transcriptome can be passed down to their fertilized offspring, reprogramming the epigenetic and transcriptional regulation of embryogenesis and causing embryonic developmental defects, suggesting that environmental Cu might pose a huge threat to the sustainability of fish populations." @default.
- W3208552227 created "2021-11-08" @default.
- W3208552227 creator A5000387478 @default.
- W3208552227 creator A5014298343 @default.
- W3208552227 creator A5026877316 @default.
- W3208552227 creator A5028460436 @default.
- W3208552227 creator A5032105778 @default.
- W3208552227 creator A5040839326 @default.
- W3208552227 creator A5045367859 @default.
- W3208552227 creator A5083848380 @default.
- W3208552227 date "2022-02-01" @default.
- W3208552227 modified "2023-09-26" @default.
- W3208552227 title "Effects of parental environmental copper stress on offspring development: DNA methylation modification and responses of differentially methylated region-related genes in transcriptional expression" @default.
- W3208552227 cites W1480113445 @default.
- W3208552227 cites W1548219170 @default.
- W3208552227 cites W1843670890 @default.
- W3208552227 cites W1971326367 @default.
- W3208552227 cites W1972251056 @default.
- W3208552227 cites W1977380334 @default.
- W3208552227 cites W1984083927 @default.
- W3208552227 cites W1987557775 @default.
- W3208552227 cites W1990957626 @default.
- W3208552227 cites W1998574404 @default.
- W3208552227 cites W2003142545 @default.
- W3208552227 cites W2004107728 @default.
- W3208552227 cites W2005756834 @default.
- W3208552227 cites W2007282813 @default.
- W3208552227 cites W2031708009 @default.
- W3208552227 cites W2032786545 @default.
- W3208552227 cites W2042369211 @default.
- W3208552227 cites W2052448553 @default.
- W3208552227 cites W2064127635 @default.
- W3208552227 cites W2073122969 @default.
- W3208552227 cites W2077821802 @default.
- W3208552227 cites W2080395830 @default.
- W3208552227 cites W2088903662 @default.
- W3208552227 cites W2102868331 @default.
- W3208552227 cites W2116368522 @default.
- W3208552227 cites W2137291580 @default.
- W3208552227 cites W2138881473 @default.
- W3208552227 cites W2157917165 @default.
- W3208552227 cites W2161021519 @default.
- W3208552227 cites W2165713434 @default.
- W3208552227 cites W2166236051 @default.
- W3208552227 cites W2170654934 @default.
- W3208552227 cites W2172149172 @default.
- W3208552227 cites W2292980119 @default.
- W3208552227 cites W2320009130 @default.
- W3208552227 cites W2330470562 @default.
- W3208552227 cites W2331387010 @default.
- W3208552227 cites W2335925695 @default.
- W3208552227 cites W2344332687 @default.
- W3208552227 cites W2414435908 @default.
- W3208552227 cites W2462887140 @default.
- W3208552227 cites W2470948111 @default.
- W3208552227 cites W2528786617 @default.
- W3208552227 cites W2530310179 @default.
- W3208552227 cites W2570684882 @default.
- W3208552227 cites W2760427637 @default.
- W3208552227 cites W2774762831 @default.
- W3208552227 cites W2782358406 @default.
- W3208552227 cites W2787126020 @default.
- W3208552227 cites W2790883924 @default.
- W3208552227 cites W2802659332 @default.
- W3208552227 cites W2802715832 @default.
- W3208552227 cites W2805310474 @default.
- W3208552227 cites W2805669408 @default.
- W3208552227 cites W2898480536 @default.
- W3208552227 cites W2912157567 @default.
- W3208552227 cites W2921607569 @default.
- W3208552227 cites W2967423691 @default.
- W3208552227 cites W2968658941 @default.
- W3208552227 cites W2979954110 @default.
- W3208552227 cites W2990495853 @default.
- W3208552227 cites W3000415102 @default.
- W3208552227 cites W3012085768 @default.
- W3208552227 cites W3046584962 @default.
- W3208552227 cites W3049236632 @default.
- W3208552227 cites W3166401947 @default.
- W3208552227 doi "https://doi.org/10.1016/j.jhazmat.2021.127600" @default.
- W3208552227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34801305" @default.
- W3208552227 hasPublicationYear "2022" @default.
- W3208552227 type Work @default.
- W3208552227 sameAs 3208552227 @default.
- W3208552227 citedByCount "6" @default.
- W3208552227 countsByYear W32085522272022 @default.
- W3208552227 countsByYear W32085522272023 @default.
- W3208552227 crossrefType "journal-article" @default.
- W3208552227 hasAuthorship W3208552227A5000387478 @default.
- W3208552227 hasAuthorship W3208552227A5014298343 @default.
- W3208552227 hasAuthorship W3208552227A5026877316 @default.
- W3208552227 hasAuthorship W3208552227A5028460436 @default.
- W3208552227 hasAuthorship W3208552227A5032105778 @default.
- W3208552227 hasAuthorship W3208552227A5040839326 @default.
- W3208552227 hasAuthorship W3208552227A5045367859 @default.
- W3208552227 hasAuthorship W3208552227A5083848380 @default.
- W3208552227 hasConcept C104317684 @default.
- W3208552227 hasConcept C112672928 @default.