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- W3208554057 abstract "Abstract Background COVID-19 is associated with neuropsychiatric symptoms including increased depressive, anxiety and chronic fatigue-syndrome (CFS)-like physiosomatic (previously known as psychosomatic) symptoms. Aims To delineate the associations between affective and CFS-like symptoms in COVID-19 and chest CT-scan anomalies (CCTAs), oxygen saturation (SpO 2 ), interleukin (IL)-6, IL-10, C-Reactive Protein (CRP), albumin, calcium, magnesium, soluble angiotensin converting enzyme (ACE2) and soluble advanced glycation products (sRAGEs). Method The above biomarkers were assessed in 60 COVID-19 patients and 30 heathy controls who had measurements of the Hamilton Depression (HDRS) and Anxiety (HAM-A) and the Fibromyalgia and Chronic Fatigue (FF) Rating Scales. Results Partial Least Squares-SEM analysis showed that reliable latent vectors could be extracted from a) key depressive and anxiety and physiosomatic symptoms (the physio-affective or PA-core), b) IL-6, IL-10, CRP, albumin, calcium, and sRAGEs (the immune response core); and c) different CCTAs (including ground glass opacities, consolidation, and crazy paving) and lowered SpO2% (lung lesions). PLS showed that 70.0% of the variance in the PA-core was explained by the regression on the immune response and lung lesions latent vectors. Moreover, one common “infection-immune-inflammatory (III) core” underpins pneumonia-associated CCTAs, lowered SpO2 and immune activation, and this III core explains 70% of the variance in the PA core, and a relevant part of the variance in melancholia, insomnia, and neurocognitive symptoms. Discussion Acute SARS-CoV-2 infection is accompanied by lung lesions and lowered SpO2 which both may cause activated immune-inflammatory pathways, which mediate the effects of the former on the PA-core and other neuropsychiatric symptoms due to SARS-CoV-2 infection." @default.
- W3208554057 created "2021-11-08" @default.
- W3208554057 creator A5019872290 @default.
- W3208554057 creator A5036611681 @default.
- W3208554057 creator A5081924790 @default.
- W3208554057 date "2021-06-16" @default.
- W3208554057 modified "2023-10-14" @default.
- W3208554057 title "Intersections between pneumonia, lowered oxygen saturation percentage and immune activation mediate depression, anxiety and chronic fatigue syndrome-like symptoms due to COVID-19: a nomothetic network approach" @default.
- W3208554057 cites W1167592479 @default.
- W3208554057 cites W1987945589 @default.
- W3208554057 cites W1992144053 @default.
- W3208554057 cites W1995581789 @default.
- W3208554057 cites W2002765492 @default.
- W3208554057 cites W2005033167 @default.
- W3208554057 cites W2010052045 @default.
- W3208554057 cites W2011553061 @default.
- W3208554057 cites W2019324493 @default.
- W3208554057 cites W2027993632 @default.
- W3208554057 cites W2035127805 @default.
- W3208554057 cites W2035252904 @default.
- W3208554057 cites W2040610952 @default.
- W3208554057 cites W2043769356 @default.
- W3208554057 cites W2060619742 @default.
- W3208554057 cites W2067540786 @default.
- W3208554057 cites W2078941925 @default.
- W3208554057 cites W2091469541 @default.
- W3208554057 cites W2091499641 @default.
- W3208554057 cites W2093624079 @default.
- W3208554057 cites W2102094268 @default.
- W3208554057 cites W2102634410 @default.
- W3208554057 cites W2102761280 @default.
- W3208554057 cites W2110065044 @default.
- W3208554057 cites W2114613490 @default.
- W3208554057 cites W2124756338 @default.
- W3208554057 cites W2148658155 @default.
- W3208554057 cites W2160070901 @default.
- W3208554057 cites W2582717501 @default.
- W3208554057 cites W2596124498 @default.
- W3208554057 cites W2756857996 @default.
- W3208554057 cites W2793853607 @default.
- W3208554057 cites W2796284997 @default.
- W3208554057 cites W2886049290 @default.
- W3208554057 cites W2902692270 @default.
- W3208554057 cites W2915451940 @default.
- W3208554057 cites W2955829435 @default.
- W3208554057 cites W2981657433 @default.
- W3208554057 cites W3001118548 @default.
- W3208554057 cites W3001897055 @default.
- W3208554057 cites W3003710034 @default.
- W3208554057 cites W3004837187 @default.
- W3208554057 cites W3005655936 @default.
- W3208554057 cites W3006643024 @default.
- W3208554057 cites W3006659024 @default.
- W3208554057 cites W3006912112 @default.
- W3208554057 cites W3007460166 @default.
- W3208554057 cites W3008985036 @default.
- W3208554057 cites W3009090768 @default.
- W3208554057 cites W3009231370 @default.
- W3208554057 cites W3009506062 @default.
- W3208554057 cites W3009885589 @default.
- W3208554057 cites W3011720761 @default.
- W3208554057 cites W3011821664 @default.
- W3208554057 cites W3012421327 @default.
- W3208554057 cites W3012622856 @default.
- W3208554057 cites W3012906272 @default.
- W3208554057 cites W3013468450 @default.
- W3208554057 cites W3015335260 @default.
- W3208554057 cites W3016982727 @default.
- W3208554057 cites W3020735691 @default.
- W3208554057 cites W3023723814 @default.
- W3208554057 cites W3032919150 @default.
- W3208554057 cites W3035467111 @default.
- W3208554057 cites W3040457167 @default.
- W3208554057 cites W3040660832 @default.
- W3208554057 cites W3046962646 @default.
- W3208554057 cites W3049147554 @default.
- W3208554057 cites W3049412607 @default.
- W3208554057 cites W3085234918 @default.
- W3208554057 cites W3087101165 @default.
- W3208554057 cites W3092320350 @default.
- W3208554057 cites W3094388274 @default.
- W3208554057 cites W3101401355 @default.
- W3208554057 cites W3105613079 @default.
- W3208554057 cites W3112030505 @default.
- W3208554057 cites W3112162081 @default.
- W3208554057 cites W3119632003 @default.
- W3208554057 cites W3121781111 @default.
- W3208554057 cites W3126670660 @default.
- W3208554057 cites W3128565996 @default.
- W3208554057 cites W3130206057 @default.
- W3208554057 cites W3134376424 @default.
- W3208554057 cites W3143039575 @default.
- W3208554057 cites W3144178840 @default.
- W3208554057 cites W3147343449 @default.
- W3208554057 cites W3157654466 @default.
- W3208554057 cites W3158109924 @default.
- W3208554057 cites W4211032795 @default.
- W3208554057 cites W4230438158 @default.
- W3208554057 doi "https://doi.org/10.1101/2021.06.12.21258815" @default.
- W3208554057 hasPublicationYear "2021" @default.