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- W3208563532 abstract "Objective To investigate the relationship of longitudinal trajectory of systolic blood pressure (SBP) to newonset chronic kidney disease (CKD). Methods A prospective cohort study was performed with a total of 13 985 on job and retired Kailuan Group employees who met the standard and participated in health examination. SAS Proc Traj program was used to identify the longitudinal trajectories of SBP of the first three times health examination, and 5 different SBP trajectory groups formed: lowstability trajectory group (106.42-109.43 mmHg, n=2927), medium-stability trajectory group (120.63-124.46 mmHg, n=6916), medium-high trajectory group (132.22-142.97 mmHg, n=2716), high-medium trajectory group (156.77-134.15 mmHg, n=668) and high-stability trajectory group (154.65-158.98 mmHg, n=758). Log-rank test was performed to compare the differences of new-onset CKD cumulative incidence among different SBP trajectory groups during follow-up; Multi-Cox regression model was used to analyze the effect of different SBP longitudinal trajectories on new-onset CKD. Results The mean age of 13 985 subjects was (49.5±11.0) years, including 10 712 males (76.6%) and 3273 females (23.4%), the mean follow-up time was (6.8±1.0) years. The cumulative incidence of CKD was 13.9% (1187/13 985). The cumulative incidences of CKD in low-stability trajectory group, mediumstability trajectory group, medium-high trajectory group, high-medium trajectory group and high-stability trajectory group were 7.7% (147/2927), 12.2% (514/6916), 17.8% (291/2716), 21.9% (93/668), and 35.4% (142/758), respectively, the incidence of CKD increased with elevated stability trajectory (log-rank χ2=177.561, P<0.001). Multi-Cox regression model analysis showed that with adjusted confounding factors, compared with the subjects in low-stability trajectory group, SBP longitudinal trajectories were the risk factors for new-onset CKD in medium-high trajectory group, high-medium trajectory group and high-stability trajectory group, and the HR and 95%CI were 1.36 (1.04-1.77), 1.62 (1.08-2.43) and 2.06 (1.40-3.02), respectively. And the influence of SBP longitudinal trajectory on new-onset CKD was better than that of baseline SBP level. Conclusion Elevated longitudinal trajectory of SBP is the risk factor for new-onset CKD in Kailuan group population.DOI: 10.11855/j.issn.0577-7402.2021.01.09" @default.
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- W3208563532 date "2021-01-01" @default.
- W3208563532 modified "2023-09-23" @default.
- W3208563532 title "Relationship of longitudinal trajectory of systolic blood pressure to new-onset chronic kidney disease" @default.
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