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- W3208573753 endingPage "11" @default.
- W3208573753 startingPage "1" @default.
- W3208573753 abstract "Cholesterol esters, synthesized from cholesterol with long-chain fatty acids, are essential components of plasma lipoproteins and cell membranes that participate in various metabolic processes in the body. Cholesterol can be excreted through the cholesterol reverse transport (RCT) pathway when excessive cholesterol is produced in the extrahepatic cells, which is regulated by the liver X receptor (LXR) and its downstream regulators ATP-binding cassette subfamily A member 1 (ABCA1) and ATP-binding cassette subfamily G member 1 (ABCG1) genes. Abnormal cholesterol metabolism is closely associated with the development of diabetic retinopathy (DR). However, the precise underlying mechanism of the RCT pathway in the pathogenesis of DR is still not fully understood. This review focused on cholesterol metabolism, with a particular emphasis on the RCT pathway and its correlation with the development of DR. Particular attention has been paid to the key regulators of the RCT pathway: LXR, ABCA1, and ABCG1 genes and their potential therapeutic targets in the management of DR." @default.
- W3208573753 created "2021-11-08" @default.
- W3208573753 creator A5027571386 @default.
- W3208573753 creator A5043263283 @default.
- W3208573753 creator A5067712775 @default.
- W3208573753 creator A5088901208 @default.
- W3208573753 date "2021-10-26" @default.
- W3208573753 modified "2023-10-16" @default.
- W3208573753 title "Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy" @default.
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