FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208579920> ?p ?o ?g. }

• W3208579920 endingPage "2102334" @default.
• W3208579920 startingPage "2102334" @default.
• W3208579920 abstract "Pulmonary arterial hypertension (PAH) is a rare dyspnoea-fatigue syndrome caused by a progressive increase in pulmonary vascular resistance and eventual right ventricular (RV) failure. In spite of extensive pulmonary vascular remodelling, lung function in PAH is generally well preserved, with hyperventilation and increased physiological dead space, but minimal changes in lung mechanics and only mild to moderate hypoxaemia and hypocapnia. Hypoxaemia is mainly caused by a low mixed venous oxygen tension from a decreased cardiac output. Hypocapnia is mainly caused by an increased chemosensitivity. Exercise limitation in PAH is cardiovascular rather than ventilatory or muscular. The extent of pulmonary vascular disease in PAH is defined by multipoint pulmonary vascular pressure–flow relationships with a correction for haematocrit. Pulsatile pulmonary vascular pressure–flow relationships in PAH allow for the assessment of RV hydraulic load. This analysis is possible either in the frequency domain or in the time domain. The RV in PAH adapts to increased afterload by an increased contractility to preserve its coupling to the pulmonary circulation. When this homeometric mechanism is exhausted, the RV dilates to preserve flow output by an additional heterometric mechanism. Right heart failure is then diagnosed by imaging of increased right heart dimensions and clinical systemic congestion signs and symptoms. The coupling of the RV to the pulmonary circulation is assessed by the ratio of end-systolic to arterial elastances, but these measurements are difficult. Simplified estimates of RV–pulmonary artery coupling can be obtained by magnetic resonance or echocardiographic imaging of ejection fraction." @default.
• W3208579920 created "2021-11-08" @default.
• W3208579920 creator A5006434846 @default.
• W3208579920 creator A5007818536 @default.
• W3208579920 creator A5018972286 @default.
• W3208579920 date "2021-11-04" @default.
• W3208579920 modified "2023-10-17" @default.
• W3208579920 title "The physiological basis of pulmonary arterial hypertension" @default.
• W3208579920 cites W101004924 @default.
• W3208579920 cites W1562054789 @default.
• W3208579920 cites W1581084089 @default.
• W3208579920 cites W1822055970 @default.
• W3208579920 cites W1846896554 @default.
• W3208579920 cites W1848000096 @default.
• W3208579920 cites W1897907826 @default.
• W3208579920 cites W1933423850 @default.
• W3208579920 cites W1964147659 @default.
• W3208579920 cites W1968123309 @default.
• W3208579920 cites W1968814354 @default.
• W3208579920 cites W1970380042 @default.
• W3208579920 cites W1971834063 @default.
• W3208579920 cites W1977498085 @default.
• W3208579920 cites W1977986478 @default.
• W3208579920 cites W1984349156 @default.
• W3208579920 cites W1984693219 @default.
• W3208579920 cites W1984813472 @default.
• W3208579920 cites W1985023991 @default.
• W3208579920 cites W1988943431 @default.
• W3208579920 cites W1990916250 @default.
• W3208579920 cites W1994532648 @default.
• W3208579920 cites W2005067782 @default.
• W3208579920 cites W2006142693 @default.
• W3208579920 cites W2006649825 @default.
• W3208579920 cites W2012316268 @default.
• W3208579920 cites W2013905244 @default.
• W3208579920 cites W2015770905 @default.
• W3208579920 cites W2016978338 @default.
• W3208579920 cites W2017494642 @default.
• W3208579920 cites W2017670551 @default.
• W3208579920 cites W2019902644 @default.
• W3208579920 cites W2020804009 @default.
• W3208579920 cites W2021168476 @default.
• W3208579920 cites W2023314610 @default.
• W3208579920 cites W2024657526 @default.
• W3208579920 cites W2035481848 @default.
• W3208579920 cites W2037693298 @default.
• W3208579920 cites W2042028458 @default.
• W3208579920 cites W2050100360 @default.
• W3208579920 cites W2052922092 @default.
• W3208579920 cites W2056692045 @default.
• W3208579920 cites W2067779529 @default.
• W3208579920 cites W2068900626 @default.
• W3208579920 cites W2070246824 @default.
• W3208579920 cites W2071812233 @default.
• W3208579920 cites W2074374690 @default.
• W3208579920 cites W2076641973 @default.
• W3208579920 cites W2079265896 @default.
• W3208579920 cites W2081718830 @default.
• W3208579920 cites W2083565359 @default.
• W3208579920 cites W2084200236 @default.
• W3208579920 cites W2085829410 @default.
• W3208579920 cites W2101667804 @default.
• W3208579920 cites W2102607047 @default.
• W3208579920 cites W2103186593 @default.
• W3208579920 cites W2106549268 @default.
• W3208579920 cites W2109070559 @default.
• W3208579920 cites W2112632481 @default.
• W3208579920 cites W2113996523 @default.
• W3208579920 cites W2116087813 @default.
• W3208579920 cites W2117241330 @default.
• W3208579920 cites W2118695925 @default.
• W3208579920 cites W2119487317 @default.
• W3208579920 cites W2120284533 @default.
• W3208579920 cites W2120803238 @default.
• W3208579920 cites W2122979079 @default.
• W3208579920 cites W2123028443 @default.
• W3208579920 cites W2123118146 @default.
• W3208579920 cites W2123227952 @default.
• W3208579920 cites W2123858410 @default.
• W3208579920 cites W2124549031 @default.
• W3208579920 cites W2124870395 @default.
• W3208579920 cites W2127083673 @default.
• W3208579920 cites W2135149559 @default.
• W3208579920 cites W2140148084 @default.
• W3208579920 cites W2142399805 @default.
• W3208579920 cites W2144769268 @default.
• W3208579920 cites W2145512044 @default.
• W3208579920 cites W2145950740 @default.
• W3208579920 cites W2146221414 @default.
• W3208579920 cites W2146469394 @default.
• W3208579920 cites W2146971940 @default.
• W3208579920 cites W2147384427 @default.
• W3208579920 cites W2150127080 @default.
• W3208579920 cites W2155914484 @default.
• W3208579920 cites W2158386014 @default.
• W3208579920 cites W2159117978 @default.
• W3208579920 cites W2162588332 @default.
• W3208579920 cites W2163296746 @default.

• next