Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208580044> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W3208580044 abstract "Transdermal patch combined microneedle array (MA) with iontophoresis can achieve synergistic and remarkable enhancement for drug delivery with precise electronic control. However, development of a MA patch combined with iontophoresis, that is in situ treatment, easy self-administration, and controllable delivery of liquid macromolecular drugs, is still a challenge. Here, we presented a novel iontophoresis-driven porous MA patch (IDPMAP) for in situ, patient-friendly, and active delivery of charged macromolecular drugs. IDPMAP integrates porous MA with iontophoresis into a single transdermal patch, realizing one-step drug administration strategy of “Penetration, Diffusion and Iontophoresis”. Moreover, a matching portable iontophoresis-driven device was developed for drug self-administration of IDPMAP. In vitro and in vivo studies showed that IDPMAP had excellent skin penetration ability, negligible cytotoxicity and good biocompatibility without skin irritation and hypersensitivity. In vivo transdermal insulin delivery in type-1 diabetic rats demonstrated that IDPMAP could effectively deliver insulin nanovesciles and produce robust hypoglycemic effect on diabetic rats, with more advanced controllability and efficiency compared with pristine MA or iontophoresis. IDPMAP and its portable iontophoresis-driven device are user-friendly that shows a promising potential for drug self-administration at home." @default.
- W3208580044 created "2021-11-08" @default.
- W3208580044 creator A5013307481 @default.
- W3208580044 creator A5039933653 @default.
- W3208580044 creator A5048826252 @default.
- W3208580044 creator A5050304652 @default.
- W3208580044 creator A5063235838 @default.
- W3208580044 creator A5072291924 @default.
- W3208580044 creator A5091327743 @default.
- W3208580044 date "2020-01-01" @default.
- W3208580044 modified "2023-09-23" @default.
- W3208580044 title "Iontophoresis-Driven Porous Microneedle Array Patch for Active Transdermal Drug Delivery" @default.
- W3208580044 doi "https://doi.org/10.2139/ssrn.3677349" @default.
- W3208580044 hasPublicationYear "2020" @default.
- W3208580044 type Work @default.
- W3208580044 sameAs 3208580044 @default.
- W3208580044 citedByCount "0" @default.
- W3208580044 crossrefType "journal-article" @default.
- W3208580044 hasAuthorship W3208580044A5013307481 @default.
- W3208580044 hasAuthorship W3208580044A5039933653 @default.
- W3208580044 hasAuthorship W3208580044A5048826252 @default.
- W3208580044 hasAuthorship W3208580044A5050304652 @default.
- W3208580044 hasAuthorship W3208580044A5063235838 @default.
- W3208580044 hasAuthorship W3208580044A5072291924 @default.
- W3208580044 hasAuthorship W3208580044A5091327743 @default.
- W3208580044 hasConcept C126838900 @default.
- W3208580044 hasConcept C127413603 @default.
- W3208580044 hasConcept C136229726 @default.
- W3208580044 hasConcept C150903083 @default.
- W3208580044 hasConcept C171250308 @default.
- W3208580044 hasConcept C183529106 @default.
- W3208580044 hasConcept C192562407 @default.
- W3208580044 hasConcept C205679159 @default.
- W3208580044 hasConcept C207001950 @default.
- W3208580044 hasConcept C2775842315 @default.
- W3208580044 hasConcept C2779820397 @default.
- W3208580044 hasConcept C42475967 @default.
- W3208580044 hasConcept C71924100 @default.
- W3208580044 hasConcept C80107235 @default.
- W3208580044 hasConcept C86803240 @default.
- W3208580044 hasConcept C98274493 @default.
- W3208580044 hasConceptScore W3208580044C126838900 @default.
- W3208580044 hasConceptScore W3208580044C127413603 @default.
- W3208580044 hasConceptScore W3208580044C136229726 @default.
- W3208580044 hasConceptScore W3208580044C150903083 @default.
- W3208580044 hasConceptScore W3208580044C171250308 @default.
- W3208580044 hasConceptScore W3208580044C183529106 @default.
- W3208580044 hasConceptScore W3208580044C192562407 @default.
- W3208580044 hasConceptScore W3208580044C205679159 @default.
- W3208580044 hasConceptScore W3208580044C207001950 @default.
- W3208580044 hasConceptScore W3208580044C2775842315 @default.
- W3208580044 hasConceptScore W3208580044C2779820397 @default.
- W3208580044 hasConceptScore W3208580044C42475967 @default.
- W3208580044 hasConceptScore W3208580044C71924100 @default.
- W3208580044 hasConceptScore W3208580044C80107235 @default.
- W3208580044 hasConceptScore W3208580044C86803240 @default.
- W3208580044 hasConceptScore W3208580044C98274493 @default.
- W3208580044 hasLocation W32085800441 @default.
- W3208580044 hasOpenAccess W3208580044 @default.
- W3208580044 hasPrimaryLocation W32085800441 @default.
- W3208580044 hasRelatedWork W10815226 @default.
- W3208580044 hasRelatedWork W13031665 @default.
- W3208580044 hasRelatedWork W14046059 @default.
- W3208580044 hasRelatedWork W1422411 @default.
- W3208580044 hasRelatedWork W15301417 @default.
- W3208580044 hasRelatedWork W2791877 @default.
- W3208580044 hasRelatedWork W3447532 @default.
- W3208580044 hasRelatedWork W4186716 @default.
- W3208580044 hasRelatedWork W8315847 @default.
- W3208580044 hasRelatedWork W6154484 @default.
- W3208580044 isParatext "false" @default.
- W3208580044 isRetracted "false" @default.
- W3208580044 magId "3208580044" @default.
- W3208580044 workType "article" @default.