FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208583425> ?p ?o ?g. }

• W3208583425 endingPage "107599" @default.
• W3208583425 startingPage "107599" @default.
• W3208583425 abstract "Novel coronavirus disease 2019 (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), which can be transmitted from person to person. As of September 21, 2021, over 228 million cases were diagnosed as COVID-19 infection in more than 200 countries and regions worldwide. The death toll is more than 4.69 million and the mortality rate has reached about 2.05% as it has gradually become a global plague, and the numbers are growing. Therefore, it is important to gain a deeper understanding of the genome and protein characteristics, clinical diagnostics, pathogenic mechanisms, and the development of antiviral drugs and vaccines against the novel coronavirus to deal with the COVID-19 pandemic. The traditional biology technologies are limited for COVID-19-related studies to understand the pandemic happening. Bioinformatics is the application of computational methods and analytical tools in the field of biological research which has obvious advantages in predicting the structure, product, function, and evolution of unknown genes and proteins, and in screening drugs and vaccines from a large amount of sequence information. Here, we comprehensively summarized several of the most important methods and applications relating to COVID-19 based on currently available reports of bioinformatics technologies, focusing on future research for overcoming the virus pandemic. Based on the next-generation sequencing (NGS) and third-generation sequencing (TGS) technology, not only virus can be detected, but also high quality SARS-CoV-2 genome could be obtained quickly. The emergence of data of genome sequences, variants, haplotypes of SARS-CoV-2 help us to understand genome and protein structure, variant calling, mutation, and other biological characteristics. After sequencing alignment and phylogenetic analysis, the bat may be the natural host of the novel coronavirus. Single-cell RNA sequencing provide abundant resource for discovering the mechanism of immune response induced by COVID-19. As an entry receptor, angiotensin-converting enzyme 2 (ACE2) can be used as a potential drug target to treat COVID-19. Molecular dynamics simulation, molecular docking and artificial intelligence (AI) technology of bioinformatics methods based on drug databases for SARS-CoV-2 can accelerate the development of drugs. Meanwhile, computational approaches are helpful to identify suitable vaccines to prevent COVID-19 infection through reverse vaccinology, Immunoinformatics and structural vaccinology." @default.
• W3208583425 created "2021-11-08" @default.
• W3208583425 creator A5015733934 @default.
• W3208583425 creator A5024579822 @default.
• W3208583425 creator A5030816026 @default.
• W3208583425 creator A5058302174 @default.
• W3208583425 creator A5076567970 @default.
• W3208583425 creator A5085152562 @default.
• W3208583425 creator A5085279249 @default.
• W3208583425 date "2021-12-01" @default.
• W3208583425 modified "2023-09-27" @default.
• W3208583425 title "Comprehensive analyses of bioinformatics applications in the fight against COVID-19 pandemic" @default.
• W3208583425 cites W1963995582 @default.
• W3208583425 cites W1987134040 @default.
• W3208583425 cites W2055043387 @default.
• W3208583425 cites W2057987200 @default.
• W3208583425 cites W2069672947 @default.
• W3208583425 cites W2101258647 @default.
• W3208583425 cites W2102469876 @default.
• W3208583425 cites W2104234755 @default.
• W3208583425 cites W2105275554 @default.
• W3208583425 cites W2105668062 @default.
• W3208583425 cites W2106780559 @default.
• W3208583425 cites W2115167726 @default.
• W3208583425 cites W2132926880 @default.
• W3208583425 cites W2140466960 @default.
• W3208583425 cites W2169018946 @default.
• W3208583425 cites W2173732482 @default.
• W3208583425 cites W2284201926 @default.
• W3208583425 cites W2470646526 @default.
• W3208583425 cites W2550293637 @default.
• W3208583425 cites W2605343262 @default.
• W3208583425 cites W2610356532 @default.
• W3208583425 cites W2620298867 @default.
• W3208583425 cites W2804822363 @default.
• W3208583425 cites W2904155504 @default.
• W3208583425 cites W2917705075 @default.
• W3208583425 cites W2920103168 @default.
• W3208583425 cites W2937204944 @default.
• W3208583425 cites W2942745415 @default.
• W3208583425 cites W2944548358 @default.
• W3208583425 cites W2953173925 @default.
• W3208583425 cites W2983321172 @default.
• W3208583425 cites W2985346127 @default.
• W3208583425 cites W2998867693 @default.
• W3208583425 cites W2999044305 @default.
• W3208583425 cites W3000771439 @default.
• W3208583425 cites W3001118548 @default.
• W3208583425 cites W3001195213 @default.
• W3208583425 cites W3001211201 @default.
• W3208583425 cites W3001897055 @default.
• W3208583425 cites W3002108456 @default.
• W3208583425 cites W3002533507 @default.
• W3208583425 cites W3003217347 @default.
• W3208583425 cites W3003223635 @default.
• W3208583425 cites W3003464757 @default.
• W3208583425 cites W3003573988 @default.
• W3208583425 cites W3003637715 @default.
• W3208583425 cites W3003668884 @default.
• W3208583425 cites W3003951199 @default.
• W3208583425 cites W3004239190 @default.
• W3208583425 cites W3004280078 @default.
• W3208583425 cites W3004318991 @default.
• W3208583425 cites W3004517278 @default.
• W3208583425 cites W3004815273 @default.
• W3208583425 cites W3005091255 @default.
• W3208583425 cites W3005417802 @default.
• W3208583425 cites W3006967091 @default.
• W3208583425 cites W3008116551 @default.
• W3208583425 cites W3008869844 @default.
• W3208583425 cites W3009629841 @default.
• W3208583425 cites W3010373510 @default.
• W3208583425 cites W3011134208 @default.
• W3208583425 cites W3012994592 @default.
• W3208583425 cites W3013576986 @default.
• W3208583425 cites W3014703367 @default.
• W3208583425 cites W3015608194 @default.
• W3208583425 cites W3015914307 @default.
• W3208583425 cites W3015959833 @default.
• W3208583425 cites W3016099155 @default.
• W3208583425 cites W3016304978 @default.
• W3208583425 cites W3016553966 @default.
• W3208583425 cites W3016620140 @default.
• W3208583425 cites W3016907473 @default.
• W3208583425 cites W3017669300 @default.
• W3208583425 cites W3018334611 @default.
• W3208583425 cites W3021655800 @default.
• W3208583425 cites W3021923959 @default.
• W3208583425 cites W3022254624 @default.
• W3208583425 cites W3022734398 @default.
• W3208583425 cites W3023013969 @default.
• W3208583425 cites W3025899282 @default.
• W3208583425 cites W3033383967 @default.
• W3208583425 cites W3034168389 @default.
• W3208583425 cites W3036529319 @default.
• W3208583425 cites W3036707773 @default.
• W3208583425 cites W3036778916 @default.
• W3208583425 cites W3040508291 @default.

• next