FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208583555> ?p ?o ?g. }

• W3208583555 endingPage "7906" @default.
• W3208583555 startingPage "7893" @default.
• W3208583555 abstract "Sevoflurane (Sev) is a volatile anesthetic that can inhibit tumor malignancy. Glioma is a main brain problem, but the mechanism of Sev in glioma progression is largely unclear. This study aims to explore a potential regulatory network of long noncoding RNA (lncRNA)/microRNA (miRNA)/mRNA associated with the function of Sev in glioma progression. LncRNA HMMR antisense RNA 1 (HMMR-AS1), miR-7 and cyclin-dependent kinase 4 (CDK4) abundances were examined via quantitative reverse transcription polymerase chain reaction and western blot. Cell viability, invasion, and colony formation ability were analyzed via cell counting kit-8, transwell analysis, and colony formation. The target association was analyzed via dual-luciferase reporter analysis and RNA pull-down. The in vivo function of Sev was investigated by xenograft model. HMMR-AS1 abundance was increased in glioma tissues and cells, and reduced via Sev. Sev constrained cell viability, invasion, and colony formation ability via decreasing HMMR-AS1 in glioma cells. miR-7 expression was decreased in glioma, and was targeted via HMMR-AS1. HMMR-AS1 silence restrained cell viability, invasion, and colony formation ability by up-regulating miR-7 in glioma cells. Sev increases miR-7 abundance via decreasing HMMR-AS1. CDK4 was targeted via miR-7, and highly expressed in glioma. miR-7 overexpression inhibited cell viability, invasion, and colony formation ability via reducing CDK4 in glioma cells. CDK4 expression was reduced by Sev via HMMR-AS1/miR-7 axis. Sev suppressed cell growth in glioma by regulating HMMR-AS1. Sev represses glioma cell progression by regulating HMMR-AS1/miR-7/CDK4 axis." @default.
• W3208583555 created "2021-11-08" @default.
• W3208583555 creator A5011916630 @default.
• W3208583555 creator A5044466626 @default.
• W3208583555 creator A5060260491 @default.
• W3208583555 creator A5063195414 @default.
• W3208583555 date "2021-01-01" @default.
• W3208583555 modified "2023-09-24" @default.
• W3208583555 title "Sevoflurane inhibits progression of glioma via regulating the HMMR antisense RNA 1/microRNA-7/cyclin dependent kinase 4 axis" @default.
• W3208583555 cites W1555664180 @default.
• W3208583555 cites W2083836886 @default.
• W3208583555 cites W2107277218 @default.
• W3208583555 cites W2161498998 @default.
• W3208583555 cites W2171398108 @default.
• W3208583555 cites W2192080449 @default.
• W3208583555 cites W2223740898 @default.
• W3208583555 cites W2240078825 @default.
• W3208583555 cites W2402448846 @default.
• W3208583555 cites W2526615614 @default.
• W3208583555 cites W2552048629 @default.
• W3208583555 cites W2552907420 @default.
• W3208583555 cites W2607129810 @default.
• W3208583555 cites W2738155789 @default.
• W3208583555 cites W2766132918 @default.
• W3208583555 cites W2786479496 @default.
• W3208583555 cites W2789326851 @default.
• W3208583555 cites W2793711924 @default.
• W3208583555 cites W2797140456 @default.
• W3208583555 cites W2810223238 @default.
• W3208583555 cites W2887975472 @default.
• W3208583555 cites W2891937576 @default.
• W3208583555 cites W2895938244 @default.
• W3208583555 cites W2906376872 @default.
• W3208583555 cites W2913928134 @default.
• W3208583555 cites W2923272925 @default.
• W3208583555 cites W2936329589 @default.
• W3208583555 cites W2944488602 @default.
• W3208583555 cites W2945377229 @default.
• W3208583555 cites W2945788231 @default.
• W3208583555 cites W2950708296 @default.
• W3208583555 cites W2957698988 @default.
• W3208583555 cites W2959454936 @default.
• W3208583555 cites W2966693400 @default.
• W3208583555 cites W2996161270 @default.
• W3208583555 cites W2996469637 @default.
• W3208583555 cites W2999121259 @default.
• W3208583555 cites W3007726005 @default.
• W3208583555 cites W3009203128 @default.
• W3208583555 cites W3010974777 @default.
• W3208583555 cites W3021358214 @default.
• W3208583555 cites W3031879108 @default.
• W3208583555 cites W3033500945 @default.
• W3208583555 cites W3036772952 @default.
• W3208583555 cites W3037212044 @default.
• W3208583555 cites W3082392384 @default.
• W3208583555 cites W3136373236 @default.
• W3208583555 cites W3152824476 @default.
• W3208583555 cites W3164231790 @default.
• W3208583555 cites W3164541000 @default.
• W3208583555 cites W3183207393 @default.
• W3208583555 cites W3185566778 @default.
• W3208583555 cites W3192145732 @default.
• W3208583555 cites W4211105004 @default.
• W3208583555 cites W3025328961 @default.
• W3208583555 doi "https://doi.org/10.1080/21655979.2021.1976712" @default.
• W3208583555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34719318" @default.
• W3208583555 hasPublicationYear "2021" @default.
• W3208583555 type Work @default.
• W3208583555 sameAs 3208583555 @default.
• W3208583555 citedByCount "5" @default.
• W3208583555 countsByYear W32085835552021 @default.
• W3208583555 countsByYear W32085835552022 @default.
• W3208583555 countsByYear W32085835552023 @default.
• W3208583555 crossrefType "journal-article" @default.
• W3208583555 hasAuthorship W3208583555A5011916630 @default.
• W3208583555 hasAuthorship W3208583555A5044466626 @default.
• W3208583555 hasAuthorship W3208583555A5060260491 @default.
• W3208583555 hasAuthorship W3208583555A5063195414 @default.
• W3208583555 hasBestOaLocation W32085835551 @default.
• W3208583555 hasConcept C104317684 @default.
• W3208583555 hasConcept C105580179 @default.
• W3208583555 hasConcept C145059251 @default.
• W3208583555 hasConcept C1491633281 @default.
• W3208583555 hasConcept C153911025 @default.
• W3208583555 hasConcept C202416437 @default.
• W3208583555 hasConcept C2778227246 @default.
• W3208583555 hasConcept C29537977 @default.
• W3208583555 hasConcept C502942594 @default.
• W3208583555 hasConcept C53227056 @default.
• W3208583555 hasConcept C54355233 @default.
• W3208583555 hasConcept C62112901 @default.
• W3208583555 hasConcept C62203573 @default.
• W3208583555 hasConcept C67705224 @default.
• W3208583555 hasConcept C86803240 @default.
• W3208583555 hasConceptScore W3208583555C104317684 @default.
• W3208583555 hasConceptScore W3208583555C105580179 @default.
• W3208583555 hasConceptScore W3208583555C145059251 @default.
• W3208583555 hasConceptScore W3208583555C1491633281 @default.

• next