Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208585509> ?p ?o ?g. }
- W3208585509 endingPage "112349" @default.
- W3208585509 startingPage "112349" @default.
- W3208585509 abstract "Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults without diabetes. Primary MN has been associated with circulating antibodies against native podocyte antigens, including phospholipase A2 receptor (PLA2R); however, precision therapy targeting the signaling cascade of PLA2R activation is lacking. Both PLA2R and the mammalian target of rapamycin (mTOR) exist in podocytes, but the interplay between these two proteins and their roles in MN warrants further exploration. This study aimed to investigate the crosstalk between PLA2R activation and mTOR signaling in a human podocyte cell line. We demonstrated that podocyte apoptosis was induced by Group IB secretory phospholipase A2 (sPLA2IB) in a concentration- and time-dependent manner via upregulation of phosphoinositide 3-kinase (PI3K), protein kinase B (AKT), and mTOR, and inhibited by rapamycin or LY294002. Furthermore, aberrant activation of the PI3K/AKT/mTOR pathway triggers both extrinsic (caspase-8 and caspase-3) and intrinsic (Bcl-2-associated X protein [BAX], B-cell lymphoma 2 [BCL-2], cytochrome c, caspase-9, and caspase-3) apoptotic cascades in podocytes. The therapeutic implications of our findings are that strategies to reduce PLA2R activation and PI3K/AKT/mTOR pathway inhibition in PLA2R-activated podocytes help protect podocytes from apoptosis. The therapeutic potential of rapamycin shown in this study provides cellular evidence supporting the repurposing of rapamycin for MN treatment." @default.
- W3208585509 created "2021-11-08" @default.
- W3208585509 creator A5007882410 @default.
- W3208585509 creator A5020802036 @default.
- W3208585509 creator A5021357410 @default.
- W3208585509 creator A5027452674 @default.
- W3208585509 creator A5043251370 @default.
- W3208585509 creator A5046630229 @default.
- W3208585509 date "2021-12-01" @default.
- W3208585509 modified "2023-10-18" @default.
- W3208585509 title "Rapamycin attenuates PLA2R activation-mediated podocyte apoptosis via the PI3K/AKT/mTOR pathway" @default.
- W3208585509 cites W1529396499 @default.
- W3208585509 cites W1745634660 @default.
- W3208585509 cites W1970002782 @default.
- W3208585509 cites W1978587144 @default.
- W3208585509 cites W1986167294 @default.
- W3208585509 cites W1997472169 @default.
- W3208585509 cites W1997846247 @default.
- W3208585509 cites W2002032734 @default.
- W3208585509 cites W2009183786 @default.
- W3208585509 cites W2015749195 @default.
- W3208585509 cites W2023720190 @default.
- W3208585509 cites W2027727579 @default.
- W3208585509 cites W2046580368 @default.
- W3208585509 cites W2070191679 @default.
- W3208585509 cites W2083760961 @default.
- W3208585509 cites W2091165702 @default.
- W3208585509 cites W2104270462 @default.
- W3208585509 cites W2108432978 @default.
- W3208585509 cites W2109508815 @default.
- W3208585509 cites W2114156291 @default.
- W3208585509 cites W2115472834 @default.
- W3208585509 cites W2116328199 @default.
- W3208585509 cites W2125346357 @default.
- W3208585509 cites W2138002856 @default.
- W3208585509 cites W2147160088 @default.
- W3208585509 cites W2159110261 @default.
- W3208585509 cites W2166822765 @default.
- W3208585509 cites W2167417098 @default.
- W3208585509 cites W2196622463 @default.
- W3208585509 cites W2329004735 @default.
- W3208585509 cites W2338867472 @default.
- W3208585509 cites W2395598045 @default.
- W3208585509 cites W2438502441 @default.
- W3208585509 cites W2513960786 @default.
- W3208585509 cites W2516435885 @default.
- W3208585509 cites W2550902247 @default.
- W3208585509 cites W2571369025 @default.
- W3208585509 cites W2590067792 @default.
- W3208585509 cites W2590398901 @default.
- W3208585509 cites W2605526923 @default.
- W3208585509 cites W2606888265 @default.
- W3208585509 cites W2617482626 @default.
- W3208585509 cites W2640390980 @default.
- W3208585509 cites W2745663953 @default.
- W3208585509 cites W2749505528 @default.
- W3208585509 cites W2788640168 @default.
- W3208585509 cites W2841355558 @default.
- W3208585509 cites W2910019464 @default.
- W3208585509 cites W2911381983 @default.
- W3208585509 cites W2923057410 @default.
- W3208585509 cites W2953848769 @default.
- W3208585509 cites W2967764568 @default.
- W3208585509 cites W2969256811 @default.
- W3208585509 cites W2969918635 @default.
- W3208585509 cites W2973098336 @default.
- W3208585509 cites W2983128022 @default.
- W3208585509 cites W2988338433 @default.
- W3208585509 cites W3005337864 @default.
- W3208585509 cites W3094954267 @default.
- W3208585509 cites W3097237610 @default.
- W3208585509 cites W3107876787 @default.
- W3208585509 cites W3118525048 @default.
- W3208585509 doi "https://doi.org/10.1016/j.biopha.2021.112349" @default.
- W3208585509 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34700229" @default.
- W3208585509 hasPublicationYear "2021" @default.
- W3208585509 type Work @default.
- W3208585509 sameAs 3208585509 @default.
- W3208585509 citedByCount "10" @default.
- W3208585509 countsByYear W32085855092022 @default.
- W3208585509 countsByYear W32085855092023 @default.
- W3208585509 crossrefType "journal-article" @default.
- W3208585509 hasAuthorship W3208585509A5007882410 @default.
- W3208585509 hasAuthorship W3208585509A5020802036 @default.
- W3208585509 hasAuthorship W3208585509A5021357410 @default.
- W3208585509 hasAuthorship W3208585509A5027452674 @default.
- W3208585509 hasAuthorship W3208585509A5043251370 @default.
- W3208585509 hasAuthorship W3208585509A5046630229 @default.
- W3208585509 hasBestOaLocation W32085855091 @default.
- W3208585509 hasConcept C134018914 @default.
- W3208585509 hasConcept C185592680 @default.
- W3208585509 hasConcept C190283241 @default.
- W3208585509 hasConcept C2776912716 @default.
- W3208585509 hasConcept C2777146197 @default.
- W3208585509 hasConcept C2777921159 @default.
- W3208585509 hasConcept C2779561371 @default.
- W3208585509 hasConcept C2780091579 @default.
- W3208585509 hasConcept C2781322055 @default.