FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208593946> ?p ?o ?g. }

• W3208593946 endingPage "10" @default.
• W3208593946 startingPage "1" @default.
• W3208593946 abstract "Since a portion of patients with nasopharyngeal carcinoma (NPC) do not benefit much from current standard treatments, it is still needed to discover new therapeutic drugs to improve the prognosis of the patients. Considering that Chinese traditional medicine plays a role in inhibiting tumor progression, in this study, we aimed to investigate whether a Chinese herbal formula, Qing Yan Li Ge Tang (QYLGT), has the anticancer activity in NPC cells and explore the underlying mechanism as well. MTT assay, colony formation assay, immunoblotting assay, and DNA laddering assay were performed to assess cell viability, cell colony formation, protein expression, and DNA fragmentation, respectively. Results show that QYLGT was able to inhibit the cell viability and decrease colony formation ability in NPC cells. QYLGT could also increase the formation of intracellular vacuoles and induce the autophagy-related protein expressions, including Atg3, Atg6, and Atg12-Atg5 conjugate in NPC cells. Treatment with an autophagy inhibitor, 3-methyladenine, could significantly recover QYLGT-inhibited cell viability of NPC cells. In addition, QYLGT did not significantly induce apoptosis in NPC cells. We also found that QYLGT had the ability to activate phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of the rapamycin (mTOR) pathway. Treatment with PI3K inhibitors, LY294002 and wortmannin, or mTOR inhibitors, rapamycin and Torin 1, could not only recover QYLGT-inhibited cell viability of NPC cells but also inhibit Atg3 expression. Taken together, our results demonstrated that QYLGT could induce autophagic cell death in NPC cells through the PI3K/Akt/mTOR pathway." @default.
• W3208593946 created "2021-11-08" @default.
• W3208593946 creator A5022514812 @default.
• W3208593946 creator A5032699557 @default.
• W3208593946 creator A5038332780 @default.
• W3208593946 creator A5042026897 @default.
• W3208593946 creator A5043656715 @default.
• W3208593946 creator A5052791381 @default.
• W3208593946 creator A5067649794 @default.
• W3208593946 creator A5069486670 @default.
• W3208593946 creator A5076668339 @default.
• W3208593946 creator A5079996432 @default.
• W3208593946 creator A5090661279 @default.
• W3208593946 date "2021-11-02" @default.
• W3208593946 modified "2023-10-12" @default.
• W3208593946 title "Qing Yan Li Ge Tang, a Chinese Herbal Formula, Induces Autophagic Cell Death through the PI3K/Akt/mTOR Pathway in Nasopharyngeal Carcinoma Cells In Vitro" @default.
• W3208593946 cites W1590797494 @default.
• W3208593946 cites W1629179716 @default.
• W3208593946 cites W1972016574 @default.
• W3208593946 cites W1972542282 @default.
• W3208593946 cites W1981284981 @default.
• W3208593946 cites W1994938996 @default.
• W3208593946 cites W1998284302 @default.
• W3208593946 cites W1998354357 @default.
• W3208593946 cites W2014220377 @default.
• W3208593946 cites W2020014470 @default.
• W3208593946 cites W2039767431 @default.
• W3208593946 cites W2072772974 @default.
• W3208593946 cites W2091621841 @default.
• W3208593946 cites W2091718668 @default.
• W3208593946 cites W2102310008 @default.
• W3208593946 cites W2105959269 @default.
• W3208593946 cites W2112639278 @default.
• W3208593946 cites W2127939726 @default.
• W3208593946 cites W2138780264 @default.
• W3208593946 cites W2144825354 @default.
• W3208593946 cites W2150231490 @default.
• W3208593946 cites W2158535498 @default.
• W3208593946 cites W2167789852 @default.
• W3208593946 cites W2222937713 @default.
• W3208593946 cites W2336661473 @default.
• W3208593946 cites W2512526160 @default.
• W3208593946 cites W2536203302 @default.
• W3208593946 cites W2568408092 @default.
• W3208593946 cites W2613581754 @default.
• W3208593946 cites W2725732284 @default.
• W3208593946 cites W2745798279 @default.
• W3208593946 cites W2765243847 @default.
• W3208593946 cites W2767370800 @default.
• W3208593946 cites W2767499464 @default.
• W3208593946 cites W2795455346 @default.
• W3208593946 cites W2796331493 @default.
• W3208593946 cites W2800473669 @default.
• W3208593946 cites W2809324976 @default.
• W3208593946 cites W2884987394 @default.
• W3208593946 cites W2913389688 @default.
• W3208593946 cites W2928812270 @default.
• W3208593946 cites W2948608028 @default.
• W3208593946 cites W2953651531 @default.
• W3208593946 cites W2954821780 @default.
• W3208593946 cites W2960383467 @default.
• W3208593946 cites W2982547531 @default.
• W3208593946 cites W3011366455 @default.
• W3208593946 cites W3119952098 @default.
• W3208593946 cites W911801646 @default.
• W3208593946 doi "https://doi.org/10.1155/2021/9925684" @default.
• W3208593946 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8577896" @default.
• W3208593946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34765012" @default.
• W3208593946 hasPublicationYear "2021" @default.
• W3208593946 type Work @default.
• W3208593946 sameAs 3208593946 @default.
• W3208593946 citedByCount "1" @default.
• W3208593946 countsByYear W32085939462023 @default.
• W3208593946 crossrefType "journal-article" @default.
• W3208593946 hasAuthorship W3208593946A5022514812 @default.
• W3208593946 hasAuthorship W3208593946A5032699557 @default.
• W3208593946 hasAuthorship W3208593946A5038332780 @default.
• W3208593946 hasAuthorship W3208593946A5042026897 @default.
• W3208593946 hasAuthorship W3208593946A5043656715 @default.
• W3208593946 hasAuthorship W3208593946A5052791381 @default.
• W3208593946 hasAuthorship W3208593946A5067649794 @default.
• W3208593946 hasAuthorship W3208593946A5069486670 @default.
• W3208593946 hasAuthorship W3208593946A5076668339 @default.
• W3208593946 hasAuthorship W3208593946A5079996432 @default.
• W3208593946 hasAuthorship W3208593946A5090661279 @default.
• W3208593946 hasBestOaLocation W32085939461 @default.
• W3208593946 hasConcept C102568950 @default.
• W3208593946 hasConcept C126322002 @default.
• W3208593946 hasConcept C185592680 @default.
• W3208593946 hasConcept C190062978 @default.
• W3208593946 hasConcept C190283241 @default.
• W3208593946 hasConcept C203522944 @default.
• W3208593946 hasConcept C2778308172 @default.
• W3208593946 hasConcept C2778997737 @default.
• W3208593946 hasConcept C2780783641 @default.
• W3208593946 hasConcept C2781000418 @default.
• W3208593946 hasConcept C31573885 @default.
• W3208593946 hasConcept C502942594 @default.

• next